History of research concerning the ependyma: a view from inside the human brain [PDF]
Frontiers in Cellular Neuroscience, 2023 The history of research concerning ependymal cells is reviewed. Cilia were identified along the surface of the cerebral ventricles c1835. Numerous anatomical and histopathological studies in the late 1800’s showed irregularities in the ependymal surface ...
, Del Bigio Marc R
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VWA3A-derived ependyma promoter drives increased therapeutic protein secretion into the CSF
Molecular Therapy - Nucleic Acids, 2023 Recombinant adeno-associated viral vectors (rAAVs) are a promising strategy to treat neurodegenerative diseases because of their ability to infect non-dividing cells and confer long-term transgene expression.
Bradley T Hyman, Beverly L Davidson
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Biomolecules, 2023 The neuron loss caused by the progressive damage to the nervous system is proposed to be the main pathogenesis of neurodegenerative diseases. Ependyma is a layer of ciliated ependymal cells that participates in the formation of the brain-cerebrospinal ...
Lian Liu, Xiaochun Peng, Feng Ru Tang
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CXCR4 and CXCR6 dually limit T cell entry into the polyomavirus-infected brain [PDF]
Journal of NeuroinflammationT cell responses are vital for controlling viral infection in the central nervous system (CNS), but must be tightly regulated to limit tissue-damaging inflammation.
Kalynn M. Alexander +8 more
doaj +2 more sources
Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain [PDF]
Frontiers in PhysiologyBackgroundPain and sickness behaviors can be elicited by systemic inflammation. We sought to determine if mature rats displayed these behaviors following overuse injury and whether they correlated with inflammatory cytokines in musculoskeletal tissues ...
Mary F. Barbe +10 more
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P2X7 receptor activation awakes a dormant stem cell niche in the adult spinal cord [PDF]
Frontiers in Cellular Neuroscience, 2023 The ependyma of the spinal cord is a latent stem cell niche that is reactivated by injury, generating new cells that migrate to the lesion site to limit the damage.
María Victoria Falco +5 more
doaj +2 more sources
Impact of aquaporin-4 and CD11c + microglia in the development of ependymal cells in the aqueduct: inferences to hydrocephalus [PDF]
Fluids and Barriers of the CNSAQP4 is expressed in the endfeet membranes of subpial and perivascular astrocytes and in the ependymal cells that line the ventricular system. The sporadic appearance of obstructive congenital hydrocephalus (OCHC) has been observed in the offspring of ...
Francisco Mayo +8 more
doaj +2 more sources
Heterogeneity of the adult mammalian forebrain neurogenic ependyma: A comprehensive cellular map [PDF]
Neural Regeneration ResearchThe presence or absence of adult neural stem cells in the mammalian forebrain ependyma has been debated for two decades. In this study, we performed single-cell RNA sequencing to investigate the cellular composition of the ependymal surface of the adult ...
Xuejiao Yang +7 more
doaj +2 more sources
In Situ Light-Source Delivery During 5-Aminulevulinic Acid-Guided High-Grade Glioma Resection: Spatial, Functional and Oncological Informed Surgery [PDF]
BiomedicinesBackground/Objectives: 5-aminulevulinic acid (5-ALA)-guided surgery for high-grade gliomas remains a challenge in neuro-oncological surgery. Inconsistent fluorescence visualisation, subjective quantification and false negatives due to blood, haemostatic ...
José Pedro Lavrador +13 more
doaj +2 more sources
Regional differences of proliferation activity in the spinal cord ependyma of adult rats
Open Life Sciences, 2012 Marcela Martončíková +1 more
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