The pathological potential of ependymal cells in mild traumatic brain injury [PDF]
Frontiers in Cellular Neuroscience, 2023 Mild traumatic brain injury (mTBI) is a common neurological condition affecting millions of individuals worldwide. Although the pathology of mTBI is not fully understood, ependymal cells present a promising approach for studying the pathogenesis of mTBI.
Diana G. Nelles +3 more
doaj +4 more sources
Ependymal cells and neurodegenerative disease: outcomes of compromised ependymal barrier function. [PDF]
Brain Commun, 2022 Abstract Within the central nervous system, ependymal cells form critical components of the blood-cerebrospinal fluid barrier and the cerebrospinal fluid-brain barrier. These barriers provide biochemical, immunological and physical protection against the entry of molecules and foreign substances into the cerebrospinal fluid while also ...
Nelles DG, Hazrati LN.
europepmc +4 more sources
Single Cell Transcriptomics of Ependymal Cells Across Age, Region and Species Reveals Cilia-Related and Metal Ion Regulatory Roles as Major Conserved Ependymal Cell Functions [PDF]
Frontiers in Cellular Neuroscience, 2021 Ependymal cells are ciliated-epithelial glial cells that develop from radial glia along the surface of the ventricles of the brain and the spinal canal.
Adam MacDonald +7 more
doaj +4 more sources
Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time [PDF]
EBioMedicine, 2016 Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have shown previously that endogenous stem cell potential is confined to ependymal cells in the adult spinal cord which could be targeted for non-invasive SCI ...
Xiaofei Li +5 more
doaj +4 more sources
ID4 Is Required for Normal Ependymal Cell Development [PDF]
Frontiers in Neuroscience, 2021 Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow and neurogenesis modulation ...
Brenda Rocamonde +4 more
doaj +6 more sources
The activation of dormant ependymal cells following spinal cord injury [PDF]
Stem Cell Research & Therapy, 2023 Ependymal cells, a dormant population of ciliated progenitors found within the central canal of the spinal cord, undergo significant alterations after spinal cord injury (SCI).
Francisco Javier Rodriguez-Jimenez +2 more
doaj +2 more sources
IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment [PDF]
Scientific Reports, 2021 Ependymal cells have multiple apical cilia that line the ventricular surfaces and the central canal of spinal cord. In cancer, the loss of ependymal cell polarity promotes the formation of different types of tumors, such as supratentorial anaplastic ...
Victor Baeza +10 more
doaj +2 more sources
Ependymal cells SCOre sweet cerebrospinal fluid. [PDF]
PLoS Biol, 2023 The subcommissural organ (SCO) is a secretory tissue located on the roof of the brain's third ventricle. A new study published in PLOS Biology finds that the SCO responds to glucose by secreting signaling molecules into the cerebrospinal fluid (CSF), thereby decreasing the local ependyma-driven CSF movement.
Liu LL, Fame RM.
europepmc +4 more sources
Ependymal cells: roles in central nervous system infections and therapeutic application [PDF]
Journal of NeuroinflammationEpendymal cells are arranged along the inner surfaces of the ventricles and the central canal of the spinal cord, providing anatomical, physiological and immunological barriers that maintain cerebrospinal fluid (CSF) homeostasis.
Shiqi Xie, Feng Li
doaj +2 more sources
RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate [PDF]
Cells, 2021 Ependymal cells reside in the adult spinal cord and display stem cell properties in vitro. They proliferate after spinal cord injury and produce neurons in lower vertebrates but predominantly astrocytes in mammals.
Robert Chevreau +13 more
doaj +2 more sources