Results 31 to 40 of about 25,194 (189)

BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors

Scientific Reports, 2021
The lateral ventricles of the adult mammalian brain are lined by a single layer of multiciliated ependymal cells, which generate a flow of cerebrospinal fluid through directional beating of their cilia as well as regulate neurogenesis through interaction
Hanae Omiya, Shima Yamaguchi, Tomoyuki Watanabe, Takaaki Kuniya, Yujin Harada, Daichi Kawaguchi, Yukiko Gotoh   +6 more
doaj   +1 more source

Hydrocephalus in Nfix^−/− Mice Is Underpinned by Changes in Ependymal Cell Physiology

Cells, 2022
Nuclear factor one X (NFIX) is a transcription factor required for normal ependymal development. Constitutive loss of Nfix in mice (Nfix−/−) is associated with hydrocephalus and sloughing of the dorsal ependyma within the lateral ventricles.
Danyon Harkins, Tracey J. Harvey, Cooper Atterton, Ingrid Miller, Laura Currey, Sabrina Oishi, Maria Kasherman, Raul Ayala Davila, Lucy Harris, Kathryn Green, Hannah Piper, Robert G. Parton, Stefan Thor, Helen M. Cooper, Michael Piper   +14 more
doaj   +1 more source

ROR2 expression and distribution in ependymal cells.

, 2023
(A-C) Immunohistochemical staining of SCO-Spondin and ROR2 in frontal brain sections containing SCO cells and ependymal cells from normoglycemic and hyperglycemic animals. Scale bar: 20 μm. ROR2 was not expressed in SCO cells.
Manuel Cifuentes (331123), Fernando Martínez (2485834), Bernard Thorens (120953), Natalia Saldivia (17020408), Eder Ramírez (17020399), María José Barahona (17020402), Luciano Ferrada (17020405), Katterine Salazar (17020411), Francisco Nualart (231550), Ernesto R. Bongarzone (4040168)   +9 more
core   +1 more source

P2X7 receptor activation awakes a dormant stem cell niche in the adult spinal cord

Frontiers in Cellular Neuroscience, 2023
The ependyma of the spinal cord is a latent stem cell niche that is reactivated by injury, generating new cells that migrate to the lesion site to limit the damage.
María Victoria Falco, Gabriela Fabbiani, Cecilia Maciel, Spring Valdivia, Nathalia Vitureira, Raúl E. Russo   +5 more
doaj   +1 more source

Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties [PDF]

, 2022
Spinal cord ependymal cells display neural stem cell properties in vitro and generate scar-forming astrocytes and remyelinating oligodendrocytes after injury.
Zamboni, Margherita, Brismar, Hjalmar, Brismar, Hjalmar,, Llorens-Bobadilla, Enric, Clevers, Hans, Göritz, Christian, Basak, Onur,, Goritz, Christian,, Stenudd, Moa,, Zhang, Shupei,, Blom, Hans, Barnabe-Heider, Fanie,, Barnabé-Heider, Fanie, Frisen, Jonas,, Clevers, Hans,, Sabelström, Hanna, Stenudd, Moa, Frisén, Jonas, Llorens-Bobadilla, Enric,, Zamboni, Margherita,, Zhang, Shupei, Basak, Onur, Blom, Hans,, Sabelstrom, Hanna,   +23 more
core   +1 more source

Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions. [PDF]

PLoS ONE, 2014
The adult mammalian spinal cord has limited regenerative capacity in settings such as spinal cord injury (SCI) and multiple sclerosis (MS). Recent studies have revealed that ependymal cells lining the central canal possess latent neural stem cell ...
Steve Lacroix, Laura K Hamilton, Alexandre Vaugeois, Stéfanny Beaudoin, Christian Breault-Dugas, Isabelle Pineau, Sébastien A Lévesque, Catherine-Alexandra Grégoire, Karl J L Fernandes   +8 more
doaj   +1 more source

Microglia activated by microbial neuraminidase contributes to ependymal cell death

Fluids and Barriers of the CNS, 2021
The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model.
María del Mar Fernández-Arjona, Ana León-Rodríguez, María Dolores López-Ávalos, Jesús M. Grondona   +3 more
doaj   +1 more source

Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing.

PLoS Biology, 2023
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus.
Francisco Nualart, Manuel Cifuentes, Eder Ramírez, Fernando Martínez, María José Barahona, Luciano Ferrada, Natalia Saldivia, Ernesto R Bongarzone, Bernard Thorens, Katterine Salazar   +9 more
doaj   +1 more source

Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain. [PDF]

PLoS ONE, 2013
Adherens junctions (AJs) play a role in mechanically connecting adjacent cells to maintain tissue structure, particularly in epithelial cells. The major cell-cell adhesion molecules at AJs are cadherins and nectins.
Hideaki Yamamoto, Tomohiko Maruo, Takashi Majima, Hiroyoshi Ishizaki, Miki Tanaka-Okamoto, Jun Miyoshi, Kenji Mandai, Yoshimi Takai   +7 more
doaj   +1 more source

Pathogenic role of autoantibodies at the ependyma in autoimmune disorders of the central nervous system

Frontiers in Cellular Neuroscience, 2023
Ependymal cells make up the epithelial monolayer that lines the brain ventricles and the spinal cord central canal that are filled with cerebrospinal fluid.
Maxime Bigotte, Adam M. R. Groh, Romain Marignier, Romain Marignier, Jo Anne Stratton   +4 more
doaj   +1 more source