ID4 Is Required for Normal Ependymal Cell Development [PDF]
Frontiers in Neuroscience, 2021 Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow and neurogenesis modulation ...
Brenda Rocamonde +4 more
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Single Cell Transcriptomics of Ependymal Cells Across Age, Region and Species Reveals Cilia-Related and Metal Ion Regulatory Roles as Major Conserved Ependymal Cell Functions [PDF]
Frontiers in Cellular Neuroscience, 2021 Ependymal cells are ciliated-epithelial glial cells that develop from radial glia along the surface of the ventricles of the brain and the spinal canal.
Adam MacDonald +7 more
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Ependymal cell lineage reprogramming as a potential therapeutic intervention for hydrocephalus [PDF]
EMBO Molecular MedicineHydrocephalus is a common neurological condition, characterized by the excessive accumulation of cerebrospinal fluid in the cerebral ventricles. Primary treatments for hydrocephalus mainly involve neurosurgical cerebrospinal fluid diversion, which hold ...
Konstantina Kaplani +7 more
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Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice [PDF]
Cell Death and Disease, 2021 Ependymal cells have been suggested to act as neural stem cells and exert beneficial effects after spinal cord injury (SCI). However, the molecular mechanism underlying ependymal cell regulation after SCI remains unknown.
Hisao Miyajima +3 more
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Microglia activated by microbial neuraminidase contributes to ependymal cell death [PDF]
Fluids and Barriers of the CNS, 2021 The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model.
María del Mar Fernández-Arjona +3 more
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Hydrocephalus in Nfix−/− Mice Is Underpinned by Changes in Ependymal Cell Physiology [PDF]
Cells, 2022 Nuclear factor one X (NFIX) is a transcription factor required for normal ependymal development. Constitutive loss of Nfix in mice (Nfix−/−) is associated with hydrocephalus and sloughing of the dorsal ependyma within the lateral ventricles.
Danyon Harkins +14 more
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Transcriptional regulation of ependymal cell maturation within the postnatal brain [PDF]
Neural Development, 2018 Background Radial glial stem cells within the developing nervous system generate a variety of post-mitotic cells, including neurons and glial cells, as well as the specialised multi-ciliated cells that line the walls of the ventricular system, the ...
Diana Vidovic +4 more
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Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing. [PDF]
PLoS Biology, 2023 Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus.
Francisco Nualart +9 more
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Ependymal cell inflammatory activation in response to intracerebral hemorrhage [PDF]
Journal of NeuroinflammationBackground Neuroinflammation is a central pathological process in secondary brain injury following intracerebral hemorrhage (ICH). While inflammatory responses in perihematomal brain tissue have been extensively investigated, the contribution of ...
Jing Liu +20 more
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The mouse Jhy gene regulates ependymal cell differentiation and ciliogenesis. [PDF]
PLoS ONE, 2017 During the first postnatal week of mouse development, radial glial cells lining the ventricles of the brain differentiate into ependymal cells, undergoing a morphological change from pseudostratified cuboidal cells to a flattened monolayer.
Hilmarie Muniz-Talavera +1 more
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