Results 31 to 40 of about 24,385 (192)

The activation of dormant ependymal cells following spinal cord injury

Stem Cell Research & Therapy, 2023
Ependymal cells, a dormant population of ciliated progenitors found within the central canal of the spinal cord, undergo significant alterations after spinal cord injury (SCI).
Francisco Javier Rodriguez-Jimenez, Pavla Jendelova, Slaven Erceg   +2 more
doaj   +1 more source

Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

eLife, 2021
Axolotls are uniquely able to resolve spinal cord injuries, but little is known about the mechanisms underlying spinal cord regeneration. We previously found that tail amputation leads to reactivation of a developmental-like program in spinal cord ...
Emanuel Cura Costa, Leo Otsuki, Aida Rodrigo Albors, Elly M Tanaka, Osvaldo Chara   +4 more
doaj   +1 more source

Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain. [PDF]

PLoS ONE, 2013
Adherens junctions (AJs) play a role in mechanically connecting adjacent cells to maintain tissue structure, particularly in epithelial cells. The major cell-cell adhesion molecules at AJs are cadherins and nectins.
Hideaki Yamamoto, Tomohiko Maruo, Takashi Majima, Hiroyoshi Ishizaki, Miki Tanaka-Okamoto, Jun Miyoshi, Kenji Mandai, Yoshimi Takai   +7 more
doaj   +1 more source

The Ependymal Region Prevents Glioblastoma From Penetrating Into the Ventricle via a Nonmechanical Force

Frontiers in Neuroanatomy, 2021
BackgroundIntraventricular penetration is rare in glioblastoma (GBM). Whether the ependymal region including the ependyma and subventricular zone (SVZ) can prevent GBM invasion remains unclear.MethodsMagnetic resonance imaging (MRI) and haematoxylin ...
Kaishu Li, Kaishu Li, Haimin Song, Chaohu Wang, Zhiying Lin, Guozhong Yi, Runwei Yang, Bowen Ni, Ziyu Wang, Taichen Zhu, Wanghao Zhang, Xiran Wang, Zhifeng Liu, Guanglong Huang, Yawei Liu, Yawei Liu   +15 more
doaj   +1 more source

Pathogenic role of autoantibodies at the ependyma in autoimmune disorders of the central nervous system

Frontiers in Cellular Neuroscience, 2023
Ependymal cells make up the epithelial monolayer that lines the brain ventricles and the spinal cord central canal that are filled with cerebrospinal fluid.
Maxime Bigotte, Adam M. R. Groh, Romain Marignier, Romain Marignier, Jo Anne Stratton   +4 more
doaj   +1 more source

Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice [PDF]

Scientific Reports, 2021
Abstract The fusion protein of uncharacterised zinc finger translocation associated (ZFTA) and effector transcription factor of tumorigenic NF-kB signalling, RELA (ZFTA-RELA), is expressed in more than two-thirds of supratentorial ependymoma (ST-EPN-RELA), but ZFTA’s expression profile and functional analysis in multiciliated ependymal (E1 ...
Herranz Pérez, Vicente, Nakatani, Jin, Ishii, Masaki, Katada, Toshiaki, García Verdugo, José Manuel, Ohata, Shinya   +5 more
openaire   +4 more sources

Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish.

PLoS Biology, 2023
Idiopathic scoliosis (IS) is the most common spinal deformity diagnosed in childhood or early adolescence, while the underlying pathogenesis of this serious condition remains largely unknown.
Haibo Xie, Yunsi Kang, Junjun Liu, Min Huang, Zhicheng Dai, Jiale Shi, Shuo Wang, Lanqin Li, Yuan Li, Pengfei Zheng, Yi Sun, Qize Han, Jingjing Zhang, Zezhang Zhu, Leilei Xu, Pamela C Yelick, Muqing Cao, Chengtian Zhao   +17 more
doaj   +1 more source

Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus [PDF]

, 2012
The junctional adhesion molecule (JAM)-C is a widely expressed adhesion molecule regulating cell adhesion, cell polarity and inflammation. JAM-C expression and function in the central nervous system (CNS) has been poorly characterized to date.
Michel Mittelbronn, Imhof, Beat A., Aurrand-Lions, Michel, Michel Aurrand-Lions, Deutsch, Urban, Karl H Plate, Adams, Ralf H, Liebner, Stefan, Schäfer, Julia, Enzmann, Gaby, Plate, Karl H, Urban Deutsch, Beat A Imhof, Adams, Ralf Heinrich, Mittelbronn, Michel, Imhof, Beat, Mittelbronn, Michel Guy André, Plate, Karl, Gaby Enzmann, Ralf H Adams, Engelhardt, Britta, Britta Engelhardt, Lena Wyss, Stefan Liebner, Plate, Karl H., Julia Schäfer, Wyss, Lena, Adams, Ralf H.   +27 more
core   +1 more source

Single-cell RNA-sequencing of spinal cord ependymal cells from FOXJ1-EGFP mice

, 2022
The spinal cord neural stem cell potential is contained within the ependymal cells lining the central canal. Ependymal cells are, however, heterogeneous and we know little about what this reflects.
Rodrigo Albors, Aida, Molecular Cell and Developmental Biology, Storey, Kate   +2 more
core   +1 more source

Ependymal cells SCOre sweet cerebrospinal fluid

PLOS Biology, 2023
The subcommissural organ (SCO) is a secretory tissue located on the roof of the brain's third ventricle. A new study published in PLOS Biology finds that the SCO responds to glucose by secreting signaling molecules into the cerebrospinal fluid (CSF), thereby decreasing the local ependyma-driven CSF movement.
Luke L. Liu, Ryann M. Fame
openaire   +3 more sources