Results 21 to 30 of about 24,385 (192)

Primary cultures as a model for studying ependymal functions: glycogen metabolism in ependymal cells

Brain Research, 2001
Ependymal cells form a single-layered, ciliated epithelium at the interface between the cerebrospinal fluid and the brain parenchyma. Although their morphology has been studied in detail, ependymal functions remain largely speculative. We have established and characterized a previously described cell culture model to investigate ependymal glycogen ...
C, Prothmann, J, Wellard, J, Berger, B, Hamprecht, S, Verleysdonk   +4 more
openaire   +3 more sources

Age‑dependent and post‑intraventricular hemorrhage remodeling of the ependymal glycocalyx in mice [PDF]

Fluids and Barriers of the CNS
Background The ependymal glycocalyx (Gcx) is a glycan-rich apical structure that lines the ventricular brain surface. It is thought to contribute to cerebrospinal fluid dynamics and brain homeostasis by forming a selective barrier, preserving surface ...
Tomohiro Iida, Kosuke Mori, Hiroyuki Tomita, Kazufumi Ohmura, Kohtaro Taguchi, Ayumi Niwa, Tomohiro Kanayama, Shigeyuki Sugie, Hideshi Okada, Tsuyoshi Izumo, Akira Hara   +10 more
doaj   +2 more sources

Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties [PDF]

, 2022
Spinal cord ependymal cells display neural stem cell properties in vitro and generate scar-forming astrocytes and remyelinating oligodendrocytes after injury.
Zamboni, Margherita, Brismar, Hjalmar, Brismar, Hjalmar,, Llorens-Bobadilla, Enric, Clevers, Hans, Göritz, Christian, Basak, Onur,, Goritz, Christian,, Stenudd, Moa,, Zhang, Shupei,, Blom, Hans, Barnabe-Heider, Fanie,, Barnabé-Heider, Fanie, Frisen, Jonas,, Clevers, Hans,, Sabelström, Hanna, Stenudd, Moa, Frisén, Jonas, Llorens-Bobadilla, Enric,, Zamboni, Margherita,, Zhang, Shupei, Basak, Onur, Blom, Hans,, Sabelstrom, Hanna,   +23 more
core   +1 more source

Ependymal cells in development and disease

, 2016
Ependymal cells lining the walls of the ventricular system of the brain are postmitotic cells derived from radial glial progenitors during embryonic development. Within the rodent brain, ependymal cells continue to develop in the postnatal period, becoming fully mature approximately 7 days after birth.
Vidovic, Diana, Piper, Michael, Harvey, Tracey J.   +2 more
openaire   +2 more sources

The pathological potential of ependymal cells in mild traumatic brain injury

Frontiers in Cellular Neuroscience, 2023
Mild traumatic brain injury (mTBI) is a common neurological condition affecting millions of individuals worldwide. Although the pathology of mTBI is not fully understood, ependymal cells present a promising approach for studying the pathogenesis of mTBI.
Diana G. Nelles, Diana G. Nelles, Lili-Naz Hazrati, Lili-Naz Hazrati   +3 more
doaj   +1 more source

Ependymal cells and neurodegenerative disease: outcomes of compromised ependymal barrier function

Brain Communications, 2022
Abstract Within the central nervous system, ependymal cells form critical components of the blood-cerebrospinal fluid barrier and the cerebrospinal fluid-brain barrier. These barriers provide biochemical, immunological and physical protection against the entry of molecules and foreign substances into the cerebrospinal fluid while also ...
Diana G Nelles, Lili-Naz Hazrati
openaire   +2 more sources

Glioblastoma disrupts the ependymal wall and extracellular matrix structures of the subventricular zone

Fluids and Barriers of the CNS, 2022
Background Glioblastoma (GBM) is the most aggressive and common type of primary brain tumor in adults. Tumor location plays a role in patient prognosis, with tumors proximal to the lateral ventricles (LVs) presenting with worse overall survival ...
Emily S. Norton, Lauren A. Whaley, María José Ulloa-Navas, Patricia García-Tárraga, Kayleah M. Meneses, Montserrat Lara-Velazquez, Natanael Zarco, Anna Carrano, Alfredo Quiñones-Hinojosa, José Manuel García-Verdugo, Hugo Guerrero-Cázares   +10 more
doaj   +1 more source

SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis. [PDF]

J Neurosci, 2016
Hydrocephalus is a brain disorder derived from CSF accumulation due to defects in CSF clearance. Although dysfunctional apical cilia in the ependymal cell layer are causal to the onset of hydrocephalus, mechanisms underlying proper ependymal cell ...
Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H.   +12 more
europepmc   +2 more sources

Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions. [PDF]

PLoS ONE, 2014
The adult mammalian spinal cord has limited regenerative capacity in settings such as spinal cord injury (SCI) and multiple sclerosis (MS). Recent studies have revealed that ependymal cells lining the central canal possess latent neural stem cell ...
Steve Lacroix, Laura K Hamilton, Alexandre Vaugeois, Stéfanny Beaudoin, Christian Breault-Dugas, Isabelle Pineau, Sébastien A Lévesque, Catherine-Alexandra Grégoire, Karl J L Fernandes   +8 more
doaj   +1 more source

Single-cell transcriptomics of mouse spinal cord ependymal cells

, 2022
An interactive web application to further explore the spinal cord ependymal cell census and the ageing dataset. The authors created a user-friendly adult mouse spinal cord ependymal cell atlas with which to interrogate this scRNAseq ...
Rodrigo Albors, Aida, Molecular Cell and Developmental Biology, Storey, Kate   +2 more
core   +1 more source