Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids [PDF]
EMBO ReportsThe V-SVZ niche is vital for adult neurogenesis in mammals, yet its regulation in humans remains poorly understood. Current models, including brain organoids, fail to replicate the unique cytoarchitecture of this niche, particularly the multiciliated ...
Styliani Vassalou +5 more
doaj +3 more sources
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential [PDF]
Developmental Cell, 2022 Cells with latent stem ability can contribute to mammalian tissue regeneration after damage. Whether the central nervous system (CNS) harbors such cells remains controversial.
Frederico B +16 more
exaly +4 more sources
Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time
EBioMedicine, 2016 Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have shown previously that endogenous stem cell potential is confined to ependymal cells in the adult spinal cord which could be targeted for non-invasive SCI ...
Xiaofei Li +5 more
doaj +4 more sources
mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins [PDF]
EMBO ReportsEpendymal cells are multiciliated glial cells lining the ventricles of the mammalian brain. Their differentiation from progenitor cells involves cell enlargement and progresses through centriole amplification phases and ciliogenesis.
Alexia Bankolé +15 more
doaj +3 more sources
Wnt/β-catenin signaling regulates ependymal cell development and adult homeostasis [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Little is known about the cellular origin and the molecular signals that regulate spinal cord ependymal cells. In this report, we characterize Wnt-responsive progenitor cells throughout spinal cord development, showing that they ...
Teni Anbarchian +2 more
exaly +3 more sources
Six3 is required for ependymal cell maturation
Development, 2011 Ependymal cells are part of the neurogenic niche in the adult subventricular zone of the lateral ventricles, where they regulate neurogenesis and neuroblast migration. Ependymal cells are generated from radial glia cells during embryonic brain development and acquire their final characteristics postnatally.
Alfonso, Lavado, Guillermo, Oliver
openaire +4 more sources
p73 is required for ependymal cell maturation and neurogenic SVZ cytoarchitecture [PDF]
Developmental Neurobiology, 2016 [EN] The adult subventricular zone (SVZ) is a highly organized microenvironment established during the first postnatal days when radial glia cells begin to transform into type B-cells and ependymal cells, all of which will form regenerative units ...
Isabel Fariñas +2 more
exaly +4 more sources
IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment [PDF]
Scientific Reports, 2021 Ependymal cells have multiple apical cilia that line the ventricular surfaces and the central canal of spinal cord. In cancer, the loss of ependymal cell polarity promotes the formation of different types of tumors, such as supratentorial anaplastic ...
Victor Baeza +10 more
doaj +2 more sources
IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells [PDF]
Fluids and Barriers of the CNSBackground IIIG9 was originally identified as a novel regulatory subunit of protein phosphatase 1 (PP1, PPP1R32) in ependymal cells, where it localizes to cilia and adherens junctions.
María José Oviedo +8 more
doaj +2 more sources
Temporally Resolved Single-Cell RNA Sequencing Reveals Pathogenesis and Immune Responses in Intracerebral Bacille Calmette–Guérin (BCG) Infection [PDF]
PathogensBackground: In some children with immunodeficiency, Bacille Calmette–Guérin (BCG) vaccination can lead to dissemination and severe infection, including severe intracranial infection, called disseminated BCG disease (BCGosis), which is characterized by ...
Shiqi Xie +10 more
doaj +2 more sources