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Novel Strategies for Spinal Cord Regeneration [PDF]

open access: yesInternational Journal of Molecular Sciences, 2022
A spinal cord injury (SCI) is one of the most devastating lesions, as it can damage the continuity and conductivity of the central nervous system, resulting in complex pathophysiology. Encouraged by the advances in nanotechnology, stem cell biology, and materials science, researchers have proposed various interdisciplinary approaches for spinal cord ...
Adelina-Gabriela Niculescu   +2 more
exaly   +4 more sources

Foxm1 regulates neural progenitor fate during spinal cord regeneration [PDF]

open access: yesEMBO Reports, 2021
Diane Pelzer   +2 more
exaly   +2 more sources

Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur

open access: yesBioengineering, 2023
The aim of this current study was to establish a metaphyseal femoral non-union model in osteoporotic rats by comparing a power tool versus a manual tool for fracture creation. Twelve adult female Sprague Dawley rats were ovariectomized (OVX) and received
Amelie Deluca   +8 more
doaj   +1 more source

Development of a nomogram model for prediction of new adjacent vertebral compression fractures after vertebroplasty

open access: yesBMC Surgery, 2023
Background Vertebroplasty is the main minimally invasive operation for osteoporotic vertebral compression fracture (OVCF), which has the advantages of rapid pain relief and shorter recovery time. However, new adjacent vertebral compression fracture (AVCF)
Yadong Qian   +9 more
doaj   +1 more source

Synergy of Human Platelet-Derived Extracellular Vesicles with Secretome Proteins Promotes Regenerative Functions

open access: yesBiomedicines, 2022
Platelet-rich plasma is a promising regenerative therapeutic with controversial efficacy. We and others have previously demonstrated regenerative functions of human platelet lysate (HPL) as an alternative platelet-derived product.
Fausto Gueths Gomes   +12 more
doaj   +1 more source

Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2

open access: yesCommunications Biology, 2022
The guanine exchange factor DOCK2 regulates the development of immunomodulatory function in human stromal cells (mesenchymal stem/progenitor cells (MSPC) and fibroblasts), as demonstrated in three models.
Cornelia Scharler   +15 more
doaj   +1 more source

A functional corona around extracellular vesicles enhances angiogenesis, skin regeneration and immunomodulation

open access: yesJournal of Extracellular Vesicles, 2022
Nanoparticles can acquire a plasma protein corona defining their biological identity. Corona functions were previously considered for cell‐derived extracellular vesicles (EVs).
Martin Wolf   +21 more
doaj   +1 more source

Structural Changes of the Urinary Bladder After Chronic Complete Spinal Cord Injury in Minipigs [PDF]

open access: yesInternational Neurourology Journal, 2017
Purpose The aim of this study was to determine the structural changes of the urinary bladder after chronic spinal cord injury (SCI) in minipigs with the primary focus on the analysis of urinary bladder wall proteins and their quantitative distribution ...
Elena E. Foditsch   +6 more
doaj   +1 more source

The biomechanical effect of preexisting different types of disc herniation in cervical hyperextension injury

open access: yesJournal of Orthopaedic Surgery and Research, 2021
Objective Preexisting severe cervical spinal cord compression is a significant risk factor in cervical hyperextension injury, and the neurological function may deteriorate after a slight force to the forehead.
Jian-jie Wang   +8 more
doaj   +1 more source

Scalable Enrichment of Immunomodulatory Human Acute Myeloid Leukemia Cell Line-Derived Extracellular Vesicles

open access: yesCells, 2021
Acute myeloid leukemia (AML) cells can secrete trophic factors, including extracellular vesicles (EVs), instructing the stromal leukemic niche. Here, we introduce a scalable workflow for purification of immunomodulatory AML-EVs to compare their phenotype
Heide-Marie Binder   +18 more
doaj   +1 more source

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