Results 21 to 30 of about 55,024 (303)

Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury

Signal Transduction and Targeted Therapy, 2022
Spinal cord injury (SCI) involves diverse injury responses in different cell types in a temporally and spatially specific manner. Here, using single-cell transcriptomic analyses combined with classic anatomical, behavioral, electrophysiological analyses,
Chen Li, Zhourui Wu, Liqiang Zhou, Jingliang Shao, Xiao Hu, Wei Xu, Yilong Ren, Xingfei Zhu, Weihong Ge, Kunshan Zhang, Jiping Liu, Runzhi Huang, Jing Yu, Dandan Luo, Xuejiao Yang, Wenmin Zhu, Rongrong Zhu, Changhong Zheng, Yi Eve Sun, Liming Cheng   +19 more
doaj   +1 more source

Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells

Cell Reports, 2023
Summary: The RNA-binding protein Musashi-1 (MSI1) regulates the proliferation and differentiation of adult stem cells. However, its role in embryonic stem cells (ESCs) and early embryonic development remains poorly understood.
Youwei Chen, Ying Chen, Qianyan Li, Huahua Liu, Jiazhen Han, Hailin Zhang, Liming Cheng, Gufa Lin   +7 more
doaj   +1 more source

Expression of lymphatic markers in the adult rat spinal cord

Frontiers in Cellular Neuroscience, 2016
Under physiological conditions, lymphatic vessels are thought to be absent from the central nervous system (CNS), although they are widely distributed within the rest of the body. Recent work in the eye, i.e.
Alexandra eKaser-Eichberger, Falk eSchroedl, Falk eSchroedl, Lara eBieler, Lara eBieler, Andrea eTrost, Barbara eBogner, Christian eRunge, Herbert eTempfer, Herbert eTempfer, Pia eZaunmair, Pia eZaunmair, Christina eKreutzer, Christina eKreutzer, Andreas eTraweger, Andreas eTraweger, Herbert Anton Reitsamer, Sebastien eCouillard-Despres, Sebastien eCouillard-Despres   +18 more
doaj   +1 more source

Extracellular Vesicles Can Deliver Anti-inflammatory and Anti-scarring Activities of Mesenchymal Stromal Cells After Spinal Cord Injury

Frontiers in Neurology, 2019
Spinal cord injury is characterized by initial neural tissue disruption that triggers secondary damage and extensive non-resolving inflammation, which aggravates loss of function and hinders recovery.
Pasquale Romanelli, Pasquale Romanelli, Lara Bieler, Lara Bieler, Cornelia Scharler, Cornelia Scharler, Karin Pachler, Karin Pachler, Christina Kreutzer, Christina Kreutzer, Pia Zaunmair, Pia Zaunmair, Dominika Jakubecova, Dominika Jakubecova, Heike Mrowetz, Heike Mrowetz, Bruno Benedetti, Bruno Benedetti, Francisco J. Rivera, Francisco J. Rivera, Francisco J. Rivera, Francisco J. Rivera, Ludwig Aigner, Ludwig Aigner, Ludwig Aigner, Eva Rohde, Eva Rohde, Eva Rohde, Mario Gimona, Mario Gimona, Dirk Strunk, Dirk Strunk, Sebastien Couillard-Despres, Sebastien Couillard-Despres, Sebastien Couillard-Despres   +34 more
doaj   +1 more source

Platelets in Amyloidogenic Mice Are Activated and Invade the Brain

Frontiers in Neuroscience, 2020
Alzheimer’s disease (AD) is a neurodegenerative disease with a complex and not fully understood pathogenesis. Besides brain-intrinsic hallmarks such as abnormal deposition of harmful proteins, i.e., amyloid beta in plaques and hyperphosphorylated Tau in ...
Kathrin M. Kniewallner, Kathrin M. Kniewallner, Diana M. Bessa de Sousa, Diana M. Bessa de Sousa, Michael S. Unger, Michael S. Unger, Heike Mrowetz, Heike Mrowetz, Ludwig Aigner, Ludwig Aigner, Ludwig Aigner   +10 more
doaj   +1 more source

The development of a ε-polycaprolactone (PCL) scaffold for CNS repair [PDF]

, 2013
Potential treatment strategies for the repair of spinal cord injury (SCI) currently favour a combinatorial approach incorporating several factors, including exogenous cell transplantation and biocompatible scaffolds. The use of scaffolds for bridging the
Boomkamp, S.D., Rebecca Lamond (7128584), Donoghue, P.S., Lamond, R., Nikolaj Gadegaard (1292763), Riehle, M.O., Stephanie D. Boomkamp (7128587), Mathis O. Riehle (1292769), Tao, S., Barnett, S.C., Peter S. Donoghue (7128581), Tao Sun (1255119), Gadegaard, N., Susan C. Barnett (7128590)   +13 more
core   +1 more source

Allergy-induced systemic inflammation impairs tendon quality

EBioMedicine, 2022
Summary: Background: Treatment of degenerating tendons still presents a major challenge, since the aetiology of tendinopathies remains poorly understood.
Christine Lehner, Gabriel Spitzer, Patrick Langthaler, Dominika Jakubecova, Barbara Klein, Nadja Weissenbacher, Andrea Wagner, Renate Gehwolf, Eugen Trinka, Bernhard Iglseder, Bernhard Paulweber, Ludwig Aigner, Sebastien Couillard-Després, Richard Weiss, Herbert Tempfer, Andreas Traweger   +15 more
doaj   +1 more source

Axonal regeneration in lamprey spinal cord [PDF]

The Journal of Neuroscience, 1983
Spinal cords of sea lamprey larvae were transected at one of two levels: (a) rostral, at the last gill, or (b) caudal, at the cloaca. Following various recovery times, regeneration of the posteriorly projecting giant reticulospinal axons (RAs) was demonstrated by intra- axonal injection of horseradish peroxidase (HRP).
H S, Yin, M E, Selzer
openaire   +2 more sources

A summary index derived from Kinect to evaluate postural abnormalities severity in Parkinson’s Disease patients

npj Parkinson's Disease, 2022
Postural abnormalities are common disabling motor complications affecting patients with Parkinson’s disease (PD). We proposed a summary index for postural abnormalities (IPA) based on Kinect depth camera and explored the clinical value of this indicator.
Ronghua Hong, Tianyu Zhang, Zhuoyu Zhang, Zhuang Wu, Ao Lin, Xiaoyun Su, Yue Jin, Yichen Gao, Kangwen Peng, Lixi Li, Lizhen Pan, Hongping Zhi, Qiang Guan, Lingjing Jin   +13 more
doaj   +1 more source

Biocompatible exosome-modified fibrin gel accelerates the recovery of spinal cord injury by VGF-mediated oligodendrogenesis

Journal of Nanobiotechnology, 2022
Exosomes show potential for treating patients with spinal cord injury (SCI) in clinical practice, but the underlying repair mechanisms remain poorly understood, and biological scaffolds available for clinical transplantation of exosomes have yet to be ...
Xiaolie He, Li Yang, Kun Dong, Feng Zhang, Yuchen Liu, Bei Ma, Youwei Chen, Jian Hai, Rongrong Zhu, Liming Cheng   +9 more
doaj   +1 more source