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Neuroglia in Neurodegeneration: Exploring Glial Dynamics in Brain Disorders
NeurogliaNeurodegenerative diseases represent a significant global health burden, characterized by progressive loss of neuronal function and structure. While traditionally viewed as primarily neuronal disorders, recent research has highlighted the crucial roles ...
Nawab John Dar +3 more
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The role of glial cells in neurodegenerative diseases. Part 1. Characteristics and physiological functions [PDF]
Farmacja Polska, 2022 The nervous system is composed of two dominant types of cells – neurons and glial cells. They differ from each other both morphologically and physiologically.
Mateusz Maszczyk +2 more
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Studying neurodegenerative diseases in culture models
Brazilian Journal of Psychiatry, 2013 Neurodegenerative diseases are pathological conditions that have an insidious onset and chronic progression. Different models have been established to study these diseases in order to understand their underlying mechanisms and to investigate new ...
Johannes C.M. Schlachetzki +2 more
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Chinese Journal of Physiology, 2022 Epoxyeicosatrienoic acids (EETs) are fatty acid signaling molecules synthesized by cytochrome P450 epoxygenases from arachidonic acid. The biological activity of EETs is terminated when being metabolized by soluble epoxide hydrolase (sEH), a process that
Yi-Min Kuo, Yi-Hsuan Lee
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Neuroimmune Regulation of Surgery-Associated Metastases
Cells, 2021 Surgery remains an essential therapeutic approach for most solid malignancies. Although for more than a century accumulating clinical and experimental data have indicated that surgical procedures themselves may promote the appearance and progression of ...
Michael R. Shurin +2 more
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Frontiers in Aging Neuroscience, 2022 Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by progressive dementia. Accumulation of β–amyloid peptide 1–42 and phosphorylation of tau protein in the brain are the two main pathological features of AD.
Shiting Weng +9 more
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Morphological Alterations in Schizophrenia — An Interdisciplinary Review
Journal of Integrative NeuroscienceSchizophrenia is characterized by the presence and persistence of psychiatric symptoms such as delusions, hallucinations, thought disorders, or disorganized behavior for at least 1 month.
Reinhold Nafe +2 more
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Brain Sciences, 2019 Type 2 diabetes is associated with diabetic cognopathy. Anti-hyperglycemic sodium glucose transporter 2 (SGLT2) inhibitors have shown promise in reducing cognitive impairment in mice with type 2 diabetes mellitus.
Melvin R. Hayden +3 more
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Neuroglia at the Crossroads of Homoeostasis, Metabolism and Signalling: Evolution of the Concept
ASN Neuro, 2012 Ever since Rudolf Virchow in 1858 publicly announced his apprehension of neuroglia being a true connective substance, this concept has been evolving to encompass a heterogeneous population of cells with various forms and functions. We briefly compare the
Vladimir Parpura, Alexei Verkhratsky
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Microglia-Associated Neuroinflammation in Alzheimer’s Disease and Its Therapeutic Potential
NeurogliaBackground: Neuroinflammation has long been implicated in the progression of amyloid beta (Aβ) accumulation and the decline of cognitive function in Alzheimer’s disease (AD). The phenotype balance between A1 (toxic) and A2 (safe) microglial phenotypes to
Siddharth Shah, Hritvik Jain
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