Results 11 to 20 of about 16,006 (273)
, 2019 Ageing reduces the functional capacity of all organs, so does that of the nervous system; the latter is evident in the reduction of cognitive abilities, learning and memory. While the exact mechanisms of ageing of the nervous system remain elusive, it is without doubt that morpho-functional changes in a variety of neuroglial cells contribute to this ...
Verkhratsky, Alexei +3 more
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The Concept of Neuroglia [PDF]
, 2019 Neuroglia represent a diverse population of non-neuronal cells in the nervous systems, be that peripheral, central, enteric or autonomic nervous system. Arguably, these cells represent about half of the volume of the human brain. This volumetric ratio, and by extension glia to neurone ratio, not only widely differ depending on the size of the animal ...
Verkhratsky, Alexei +3 more
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Pathophysiology of Lipid Droplets in Neuroglia
Antioxidants, 2021 In recent years, increasing evidence regarding the functional importance of lipid droplets (LDs), cytoplasmic storage organelles in the central nervous system (CNS), has emerged.
Tina Smolič, Robert Zorec, Nina Vardjan
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, 2019 As the nervous system evolved from the diffused to centralised form, the neurones were joined by the appearance of the supportive cells, the neuroglia. Arguably, these non-neuronal cells evolve into a more diversified cell family than the neurones are. The first ancestral neuroglia appeared in flatworms being mesenchymal in origin.
Verkhratsky, Alexei +2 more
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P2X receptors in neuroglia [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractDifferent types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in ...
Verkhratsky, A.; id_orcid 0000-0003-2592-9898 +3 more
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Neuroglia in the healthy brain
The nervous tissue is composed of neurons and neuroglia, which by working in a tightly coordinated manner, define the function of the nervous system. Neuroglia, defined as homeostatic and defensive cells of the nervous system, are highly heterogeneous in form and function and are endowed with a remarkable plasticity that allows life-long adaptation to ...
Verkhratsky, A. +4 more
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Neuroglia in the Healthy Nervous System, Part I:Handbook of Clinical Neurology
Neuroglia in the Healthy Nervous System, Part I provides insights into newly emerging developments in neuroglia biology, focusing on the healthy nervous system. Driven by advances in genetics, transcriptomics, electrophysiological, and imaging techniques,
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Soursop leaf extract increases neuroglia and hepatic degeneration in female rats [PDF]
Universa Medicina, 2015 Background Soursop leaf contains annonaceous acetogenins and alkaloids. The acetogenins act as inhibitors of mitochondrial complex I, suppress ATP production and cause cell degeneration, whereas the alkaloids act as neurotoxins.
Ety Sari Handayani +3 more
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Purinoceptors on Neuroglia [PDF]
Molecular Neurobiology, 2009 Purinergic transmission is one of the most ancient and widespread extracellular signalling systems. In the brain, purinergic signalling plays a unique role in integrating neuronal and glial cellular circuits, as virtually every type of glial cell possesses receptors to purines and pyrimidines.
Alexei, Verkhratsky +3 more
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Toxics, 2022 Evidence is now growing that exposure to environmental pollutants during the critical early-life period of brain development may contribute to the emergence of Autism Spectrum Disorders (ASD).
Chloé Morel +6 more
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