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Trends in Cell Biology, 2023 Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal feature of astrocytes is their complex and visually enchanting morphology, referred to as bushy, spongy, and star-like. A central precept of this review is that
Keith K. Murai +5 more
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Astrocyte development—More questions than answers [PDF]
Frontiers in Cell and Developmental Biology, 2023 The past 15–20 years has seen a remarkable shift in our understanding of astrocyte contributions to central nervous system (CNS) function. Astrocytes have emerged from the shadows of neuroscience and are now recognized as key elements in a broad array of
Jana Smuts +4 more
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HepaCAM controls astrocyte self-organization and coupling
Neuron, 2021 Astrocytes extensively infiltrate the neuropil to regulate critical aspects of synaptic development and function. This process is regulated by transcellular interactions between astrocytes and neurons via cell adhesion molecules.
Katherine T Baldwin +2 more
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A spatial threshold for astrocyte calcium surge
eLifeAstrocytes are active cells involved in brain function through the bidirectional communication with neurons, in which astrocyte calcium plays a crucial role.
Marta Navarrete +7 more
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eLife, 2016 Interneurons are critical for proper neural network function and can activate Ca2+ signaling in astrocytes. However, the impact of the interneuron-astrocyte signaling into neuronal network operation remains unknown.
Perea, Gertrudis +3 more
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Astrocyte polarization in glaucoma: a new opportunity
Neural Regeneration Research, 2022 Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1 (neurotoxic) and A2 (neuroprotective).
Hao Sun, Yi-Xin Liu, Wen-Yi Guo
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Acute treatment with 17β-estradiol attenuates astrocyte-astrocyte and astrocyte-neuron communication
Glia, 2007 Astrocytes are now recognized as dynamic signaling elements in the brain. Bidirectional communication between neurons and astrocytes involves integration of neuronal inputs by astrocytes and release of gliotransmitters that modulate neuronal excitability
Rao, Shilpa P., Sikdar, Sujit Kumar
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Microfluidic co-culture system for synaptically segregated neural networks to explore astrocyte-driven neural pathology. [PDF]
Microsyst NanoengInvestigating astrocyte–neuron communication in the absence of neuron-to-neuron signalling is challenging using traditional culture systems due to the complexity of synaptic networks.
Yap YC +7 more
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Exocytosis in Astrocytes [PDF]
Biomolecules, 2021 Until recently, astrocytes were thought to be a part of a simple “brain glue” providing only a supporting role for neurons. However, the discoveries of the last two decades have proven astrocytes to be dynamic partners participating in brain metabolism and actively influencing communication between neurons.
Aleksandra Mielnicka, Piotr Michaluk
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Astrocytes in Tauopathies [PDF]
Frontiers in Neurology, 2020 Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and localization.
Reid, Matt +4 more
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