Results 1 to 10 of about 105,623 (265)

Microfluidic co-culture system for synaptically segregated neural networks to explore astrocyte-driven neural pathology [PDF]

Microsystems & Nanoengineering
Investigating astrocyte–neuron communication in the absence of neuron-to-neuron signalling is challenging using traditional culture systems due to the complexity of synaptic networks.
Yiing C. Yap, Ruth E. Musgrove, Michael C. Breadmore, Rosanne M. Guijt, Richard Wilson, Graeme Wertheimer, Anna E. King, Tracey C. Dickson   +7 more
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Microfluidic device to study spatial and temporal response of astrocyte networks in response to changes in the biochemical milieu [PDF]

Microsystems & Nanoengineering
Astrocytes are the most abundant cell type in the central nervous system and are major players in brain homeostasis and inflammation. Astrocytes form a syncytial three-dimensional (3D) network across the brain tissue.
Catherine A. Reed-McBain, Annika S. Anchan, Janmesh D. Patel, Ella P. Peterson, Ismael Gómez García, Jeremiah Riendeau, Cristian Chavira, Natalie W. Hua, Ayoung Choi, Jessica R. Saperstein, Trista J. Drew, Matthew I. Banks, Melissa Skala, Jose M. Ayuso   +13 more
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Response of Astrocyte Subpopulations Following Spinal Cord Injury

Cells, 2022
There is growing appreciation for astrocyte heterogeneity both across and within central nervous system (CNS) regions, as well as between intact and diseased states. Recent work identified multiple astrocyte subpopulations in mature brain. Interestingly,
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore   +9 more
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The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

Molecular Neurodegeneration, 2023
Background Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice.
Sidhanth Chandra, Antonio Di Meco, Hemraj B. Dodiya, Jelena Popovic, Leah K. Cuddy, Ian Q. Weigle, Xiaoqiong Zhang, Katherine Sadleir, Sangram S. Sisodia, Robert Vassar   +9 more
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Gene Enrichment Analysis of Astrocyte Subtypes in Psychiatric Disorders and Psychotropic Medication Datasets

Cells, 2022
Astrocytes have many important functions in the brain, but their roles in psychiatric disorders and their responses to psychotropic medications are still being elucidated.
Xiaolu Zhang, Alyssa Wolfinger, Xiaojun Wu, Rawan Alnafisah, Ali Imami, Abdul-rizaq Hamoud, Anna Lundh, Vladimir Parpura, Robert E. McCullumsmith, Rammohan Shukla, Sinead M. O’Donovan   +10 more
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Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity

Cell Discovery, 2023
Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is generally thought to be involved. Here we show multiple lines of evidence supporting that modulation of the sleep–wake behavior by astrocyte Ca2+ activity could ...
Wanling Peng, Xiaotong Liu, Guofen Ma, Zhaofa Wu, Ziyue Wang, Xiang Fei, Meiling Qin, Lizhao Wang, Yulong Li, Siyu Zhang, Min Xu   +10 more
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Dynamic Transitions in Neuronal Network Firing Sustained by Abnormal Astrocyte Feedback

Neural Plasticity, 2020
Astrocytes play a crucial role in neuronal firing activity. Their abnormal state may lead to the pathological transition of neuronal firing patterns and even induce seizures.
Yangyang Yu, Zhixuan Yuan, Yongchen Fan, Jiajia Li, Ying Wu   +4 more
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Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model

Molecular Brain, 2021
The morphological dynamics of astrocytes are altered in the hippocampus during memory induction. Astrocyte–neuron interactions on synapses are called tripartite synapses. These control the synaptic function in the central nervous system.
Moonseok Choi, Sang-Min Lee, Dongsoo Kim, Heh-In Im, Hye-Sun Kim, Yun Ha Jeong   +5 more
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Glutamate mediated astrocytic filtering of neuronal activity. [PDF]

PLoS Computational Biology, 2014
Neuron-astrocyte communication is an important regulatory mechanism in various brain functions but its complexity and role are yet to be fully understood.
Gilad Wallach, Jules Lallouette, Nitzan Herzog, Maurizio De Pittà, Eshel Ben Jacob, Hugues Berry, Yael Hanein   +6 more
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Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden

Scientific Reports, 2022
An emerging link between circadian clock function and neurodegeneration has indicated a critical role for the molecular clock in brain health. We previously reported that deletion of the core circadian clock gene Bmal1 abrogates clock function and ...
Celia A. McKee, Jiyeon Lee, Yuqi Cai, Takashi Saito, Takaomi Saido, Erik S. Musiek   +5 more
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