Results 1 to 10 of about 133,591 (301)

Astrocytes from P301S Tau mice exhibit non-canonical protein secretion and reduced morphological complexity

Neural Regeneration Research
Astrocytes have important neurosupportive functions in the brain that are altered in neurodegenerative diseases by unresolved mechanisms. We showed previously that astrocytes cultured from mice transgenic for human P301S-tau (P301S-mice) recapitulate the
Aishwarya G. Nadadhur, Matthew Mason, Johanna S. Rees, Marta Sidoryk-Wegrzynowicz, Aviva M. Tolkovsky, Maria Grazia Spillantini   +5 more
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Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation

Journal of Neuroinflammation
One of the histopathological hallmarks of neuroinflammatory diseases such as multiple sclerosis (MS) is the emergence of astrocyte reactivity. Accumulating evidence suggests that excessive glycolysis may lead to astrocyte reactivity and contribute to ...
Luting Yang, Chunqing Hu, Xiaowen Chen, Mengru Sun, Jie Zhang, Zhe Feng, Tingting Cui, Ruyi Zhu, Xin Zhang, Yanxin Xiao, Ye Gong, Yang Yang, Qian Zhang, Yaling Zhang, Yaping Yan   +14 more
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Astrocytes: The Unsung Architects of Synaptic Integration and Their Role in Brain Health and Disease

Biomolecules
Astrocytes, long viewed as passive support cells, are now recognized as dynamic regulators of synaptic function. This mini review summarizes recent findings revealing that astrocyte leaflets, thin peripheral processes of astrocyte, form gap junction ...
Rosalie Elvira, Eng King Tan, Zhi Dong Zhou   +2 more
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Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling

Journal of Neuroinflammation
Background Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuroprotective activities.
Min Wang, Tian Tian, Hong Zhou, Si-Yuan Jiang, Ying-Ying Jiao, Zhu Zhu, Jiang Xia, Jian-Hua Ma, Ren-Hong Du   +8 more
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Microfluidic device to study spatial and temporal response of astrocyte networks in response to changes in the biochemical milieu

Microsystems & Nanoengineering
Astrocytes are the most abundant cell type in the central nervous system and are major players in brain homeostasis and inflammation. Astrocytes form a syncytial three-dimensional (3D) network across the brain tissue.
Catherine A. Reed-McBain, Annika S. Anchan, Janmesh D. Patel, Ella P. Peterson, Ismael Gómez García, Jeremiah Riendeau, Cristian Chavira, Natalie W. Hua, Ayoung Choi, Jessica R. Saperstein, Trista J. Drew, Matthew I. Banks, Melissa Skala, Jose M. Ayuso   +13 more
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Sox9 regulation of hexokinase 1 controls neuroinflammatory astrocyte subtypes in a rat model of neuropathic pain

Nature Communications
Neuropathic pain, caused by nerve damage, lacks effective treatments. Astrocytes drive chronic neuroinflammation in the dorsal horn, but directly targeting them is challenging due to their heterogeneity and beneficial roles. The regulation of deleterious
Yonglong Chen, Yu Liao, Huazhang Zhu, Zhaoming Wu, Yutong Wan, Xianglan Feng, Chaoyang Fan, Dengcheng Zhan, Haoyang Cai, Martin Cheung, Chi Wai Cheung, Jessica Aijia Liu   +11 more
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Astrocyte diversity and subtypes: aligning transcriptomics with multimodal perspectives

EMBO Reports
Astrocytes are considered a diverse cell population, carrying out many functions essential for supporting neuronal activity. The surge of sc/snRNA-sequencing data greatly expands our understanding of heterogeneous astrocyte gene expression, but also ...
Maroussia Hennes, Maria L Richter, Judith Fischer-Sternjak, Magdalena Götz   +3 more
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CK2 derived from brain microvascular endothelial cells induces astrocyte inflammatory response in Escherichia coli-induced meningitis.

PLoS Pathogens
Neuroinflammation within the central nervous system (CNS) is recognized as a critical pathological process in meningitic Escherichia coli (E. coli) infection, leading to severe neurodegenerative disorders and long-term sequelae.
Dong Huo, Ruicheng Yang, Jiyang Fu, Jiaqi Chen, Chen Tan, Huanchun Chen, Xiangru Wang   +6 more
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Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake.

PLoS Biology
Classical neuromodulators regulate arousal states, spanning deep sleep to vigilant wakefulness, primarily by activating cortical neurons. However, cortical astrocytes also express neuromodulatory G-protein-coupled receptors (GPCRs).
Charlotte R Taylor, Vincent Tse, Drew D Willoughby, Maxine Levesque, Trisha V Vaidyanathan, Jeanne T Paz, Kira E Poskanzer   +6 more
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Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery
Background Astrocytes, far beyond passive support cells, are critical regulators in brain homeostasis, intricately regulating synaptic plasticity, neurovascular integrity, metabolic support, and neuroimmune communication.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
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