Results 1 to 10 of about 172,284 (291)

Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis [PDF]

Nature, 2017
Astrocytes are complex glial cells with numerous fine cellular processes that infiltrate the neuropil and interact with synapses. The mechanisms that control the establishment of astrocyte morphology are unknown, and it is unclear whether impairing astrocytic infiltration of the neuropil alters synaptic connectivity.
Juan Ramirez, Katherine T Baldwin, Eray Enustun   +2 more
exaly   +3 more sources

Astrocyte Heterogeneity and Metabolic Reprogramming: Mechanisms Governing Retinal Ganglion Cell Damage in Glaucoma [PDF]

Cells
Glaucoma, a leading cause of irreversible visual impairment, is driven by progressive retinal ganglion cell (RGC) degeneration. Emerging evidence highlights astrocytes as pivotal players in its pathogenesis, with their heterogeneity and pathological ...
Yufei Hao, Dongran Liang, Mengjie Ren, Fang Kuang, Mingmei Wu   +4 more
doaj   +2 more sources

Response of Astrocyte Subpopulations Following Spinal Cord Injury

Cells, 2022
There is growing appreciation for astrocyte heterogeneity both across and within central nervous system (CNS) regions, as well as between intact and diseased states. Recent work identified multiple astrocyte subpopulations in mature brain. Interestingly,
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore   +9 more
doaj   +1 more source

Gene Enrichment Analysis of Astrocyte Subtypes in Psychiatric Disorders and Psychotropic Medication Datasets

Cells, 2022
Astrocytes have many important functions in the brain, but their roles in psychiatric disorders and their responses to psychotropic medications are still being elucidated.
Xiaolu Zhang, Alyssa Wolfinger, Xiaojun Wu, Rawan Alnafisah, Ali Imami, Abdul-rizaq Hamoud, Anna Lundh, Vladimir Parpura, Robert E. McCullumsmith, Rammohan Shukla, Sinead M. O’Donovan   +10 more
doaj   +1 more source

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

Molecular Neurodegeneration, 2023
Background Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice.
Sidhanth Chandra, Antonio Di Meco, Hemraj B. Dodiya, Jelena Popovic, Leah K. Cuddy, Ian Q. Weigle, Xiaoqiong Zhang, Katherine Sadleir, Sangram S. Sisodia, Robert Vassar   +9 more
doaj   +1 more source

Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model

Molecular Brain, 2021
The morphological dynamics of astrocytes are altered in the hippocampus during memory induction. Astrocyte–neuron interactions on synapses are called tripartite synapses. These control the synaptic function in the central nervous system.
Moonseok Choi, Sang-Min Lee, Dongsoo Kim, Heh-In Im, Hye-Sun Kim, Yun Ha Jeong   +5 more
doaj   +1 more source

Glutamate mediated astrocytic filtering of neuronal activity. [PDF]

PLoS Computational Biology, 2014
Neuron-astrocyte communication is an important regulatory mechanism in various brain functions but its complexity and role are yet to be fully understood.
Gilad Wallach, Jules Lallouette, Nitzan Herzog, Maurizio De Pittà, Eshel Ben Jacob, Hugues Berry, Yael Hanein   +6 more
doaj   +1 more source

Astrocytes Imagined

Journal of Integrative Neuroscience, 2022
The cellular, molecular and physiological basis of cognition has proved elusive until emerging studies on astrocytes. The appearance of a deliberate aggregating element in cellular neurophysiology was difficult to satisfy computationally with excitatory and inhibitory neuron physiology alone.
openaire   +3 more sources

Dynamic Transitions in Neuronal Network Firing Sustained by Abnormal Astrocyte Feedback

Neural Plasticity, 2020
Astrocytes play a crucial role in neuronal firing activity. Their abnormal state may lead to the pathological transition of neuronal firing patterns and even induce seizures.
Yangyang Yu, Zhixuan Yuan, Yongchen Fan, Jiajia Li, Ying Wu   +4 more
doaj   +1 more source

Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden

Scientific Reports, 2022
An emerging link between circadian clock function and neurodegeneration has indicated a critical role for the molecular clock in brain health. We previously reported that deletion of the core circadian clock gene Bmal1 abrogates clock function and ...
Celia A. McKee, Jiyeon Lee, Yuqi Cai, Takashi Saito, Takaomi Saido, Erik S. Musiek   +5 more
doaj   +1 more source