Results 21 to 30 of about 172,284 (291)

Astrocyte polarization in glaucoma: a new opportunity

open access: yesNeural Regeneration Research, 2022
Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1 (neurotoxic) and A2 (neuroprotective).
Yi-Xin Liu, Hao Sun, Wen-Yi Guo
doaj   +1 more source

Rapamycin attenuates acute seizure-induced astrocyte injury in mice in vivo [PDF]

open access: yes, 2017
Astrocytes have been implicated in epileptogenesis and seizure-induced brain injury. Pathological studies reveal a variety of structural abnormalities in astrocytes, such as vacuolization and astrogliosis.
Guo, Dongjun, Wong, Michael, Zou, Jia
core   +2 more sources

Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis

open access: yesParkinson's Disease, 2012
Dementia is a common feature in Parkinson’s disease (PD) and is considered to be the result of limbic and cortical Lewy bodies and/or Alzheimer changes.
Simone A. van den Berge   +3 more
doaj   +1 more source

The Neurotropic Parasite Toxoplasma gondii Induces Astrocyte Polarization Through NFκB Pathway

open access: yesFrontiers in Medicine, 2019
Background:Toxoplasma gondii is a protozoan parasite that chronically infects nearly one-third of the world's human population. In immunosuppressed individuals and fetus, infection with T.
Yu Jin   +6 more
doaj   +1 more source

Astrocyte development—More questions than answers

open access: yesFrontiers in Cell and Developmental Biology, 2023
The past 15–20 years has seen a remarkable shift in our understanding of astrocyte contributions to central nervous system (CNS) function. Astrocytes have emerged from the shadows of neuroscience and are now recognized as key elements in a broad array of
Kathryn M. Markey   +6 more
doaj   +1 more source

Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons [PDF]

open access: yes, 2016
Perinatal Asphyxia (PA) represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness.
Barreto, George E.   +5 more
core   +1 more source

Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]

open access: yes, 2015
Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Heller, JP, Rusakov, DA
core   +1 more source

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels

open access: yesNature Communications, 2023
Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood.
Michaela M. Novakovic   +7 more
doaj   +1 more source

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

open access: yesFrontiers in Physiology, 2019
The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes.
Susan Yu. Gordleeva   +3 more
doaj   +1 more source

Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration

open access: yesJournal of Neuroinflammation, 2020
Background Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans.
Sudeshna Das   +4 more
doaj   +1 more source

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