Results 21 to 30 of about 105,623 (265)

Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. [PDF]

PLoS Biology, 2012
Long-term potentiation (LTP) of synaptic transmission represents the cellular basis of learning and memory. Astrocytes have been shown to regulate synaptic transmission and plasticity.
Marta Navarrete, Gertrudis Perea, David Fernandez de Sevilla, Marta Gómez-Gonzalo, Angel Núñez, Eduardo D Martín, Alfonso Araque   +6 more
doaj   +1 more source

Astrocyte Reprogramming in Stroke: Opportunities and Challenges

Frontiers in Aging Neuroscience, 2022
Stroke is a major cause of morbidity and mortality worldwide. In the early stages of stroke, irreversible damage to neurons leads to high mortality and disability rates in patients.
Zhouzhou Peng, Zhouzhou Peng, Hui Lu, Hui Lu, Qingwu Yang, Qingwu Yang, Qi Xie, Qi Xie   +7 more
doaj   +1 more source

Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis

Parkinson's Disease, 2012
Dementia is a common feature in Parkinson’s disease (PD) and is considered to be the result of limbic and cortical Lewy bodies and/or Alzheimer changes.
Simone A. van den Berge, Josta T. Kevenaar, Jacqueline A. Sluijs, Elly M. Hol   +3 more
doaj   +1 more source

The Neurotropic Parasite Toxoplasma gondii Induces Astrocyte Polarization Through NFκB Pathway

Frontiers in Medicine, 2019
Background:Toxoplasma gondii is a protozoan parasite that chronically infects nearly one-third of the world's human population. In immunosuppressed individuals and fetus, infection with T.
Yu Jin, Yong Yao, Saeed El-Ashram, Saeed El-Ashram, Jiaming Tian, Jilong Shen, Yongsheng Ji   +6 more
doaj   +1 more source

Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders

Journal of Neuroinflammation, 2023
Despite extensive astrocyte activation in patients suffering from HIV-associated neurocognitive disorders (HAND), little is known about the contribution of astrocytes to HAND neuropathology.
Jingxian Lun, Yubin Li, Xuefeng Gao, Zelong Gong, Xiaoliang Chen, Jinhu Zou, Chengxing Zhou, Yuanyuan Huang, Bingliang Zhou, Pengwei Huang, Hong Cao   +10 more
doaj   +1 more source

Astrocyte development—More questions than answers

Frontiers in Cell and Developmental Biology, 2023
The past 15–20 years has seen a remarkable shift in our understanding of astrocyte contributions to central nervous system (CNS) function. Astrocytes have emerged from the shadows of neuroscience and are now recognized as key elements in a broad array of
Kathryn M. Markey, Jillian C. Saunders, Jana Smuts, Catherine R. von Reyn, Catherine R. von Reyn, A. Denise R. Garcia, A. Denise R. Garcia   +6 more
doaj   +1 more source

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels

Nature Communications, 2023
Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood.
Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya   +7 more
doaj   +1 more source

Astrocyte polarization in glaucoma: a new opportunity

Neural Regeneration Research, 2022
Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1 (neurotoxic) and A2 (neuroprotective).
Yi-Xin Liu, Hao Sun, Wen-Yi Guo
doaj   +1 more source

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

Frontiers in Physiology, 2019
The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes.
Susan Yu. Gordleeva, Anastasia V. Ermolaeva, Innokentiy A. Kastalskiy, Victor B. Kazantsev   +3 more
doaj   +1 more source

FGFR3-TACC3 fusion as a potential primary resistance mechanism to EGFR-TKI in lung adenocarcinoma harboring co-driven mutations: a case report

Frontiers in Oncology
Oncogenic driver mutations were once considered mutually exclusive in non-small cell lung cancer (NSCLC), and the optimal management for these patients with co-mutations of driver genes remains controversial.
Xiuwen Wang, Liwen Qiu, Jizhen Liang, Fei Liu, Xiaoxue Ma, Pan Yang   +5 more
doaj   +1 more source