Results 31 to 40 of about 105,623 (265)
Journal of Neuroinflammation, 2020 Background Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans.
Sudeshna Das +4 more
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Novel cell separation method for molecular analysis of neuron-astrocyte cocultures
Frontiers in Cellular Neuroscience, 2014 Over the last decade, the importance of astrocyte-neuron communication in neuronal development and synaptic plasticity has become increasingly clear. Since neuron-astrocyte interactions represent highly dynamic and reciprocal processes, we hypothesized ...
Andrea eGoudriaan +8 more
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NeuronThe mammalian nervous system is impacted by aging. Aging alters brain architecture, is associated with molecular damage, and can manifest with cognitive and motor deficits that diminish the quality of life. Astrocytes are glial cells of the CNS that regulate the development, function, and repair of neural circuits during development and adulthood ...
Lara Labarta-Bajo, Nicola J. Allen
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Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma
Frontiers in PharmacologyBackgroundTumor metabolism reprogramming is a hallmark of cancer, but metabolite-mediated intercellular communication remains poorly understood. To address this gap, we estimated and explored communication events exploring based on single‐cell RNA data ...
Qiang Liu +9 more
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Self-determination theory applied to Dark Souls: fostering motivation in video game communities
InteraccionesBackground: Video games have emerged as a significant field of study in psychology, particularly in understanding human motivation. Self-Determination Theory (SDT) posits that human motivation is driven by three basic psychological needs: autonomy ...
Fritz Fidel Váscones-Román +4 more
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Non-aggregated Aβ25-35 Upregulates Primary Astrocyte Proliferation In Vitro
Frontiers in Cellular Neuroscience, 2017 Amyloid beta (Aβ) is a peptide cleaved from amyloid precursor protein that contributes to the formation of senile plaques in Alzheimer’s disease (AD). The relationship between Aβ and astrocyte proliferation in AD remains controversial.
Elise C. Ohki +5 more
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Olig2-Lineage Astrocytes: A Distinct Subtype of Astrocytes That Differs from GFAP Astrocytes [PDF]
Frontiers in Neuroanatomy, 2018 Astrocytes are the most abundant glia cell type in the central nervous system (CNS), and are known to constitute heterogeneous populations that differ in their morphology, gene expression and function. Although glial fibrillary acidic protein (GFAP) is the cardinal cytological marker of CNS astrocytes, GFAP-negative astrocytes can easily be found in ...
Kouko Tatsumi +10 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Discover OncologyBackground Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality worldwide. Although oxidative phosphorylation (OXPHOS) has been linked to tumor progression, its prognostic significance and underlying mechanisms in LUAD remain unclear ...
Hongxia Ma +7 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source