Results 51 to 60 of about 124,424 (305)

Self-determination theory applied to Dark Souls: fostering motivation in video game communities

Interacciones
Background: Video games have emerged as a significant field of study in psychology, particularly in understanding human motivation. Self-Determination Theory (SDT) posits that human motivation is driven by three basic psychological needs: autonomy ...
Fritz Fidel Váscones-Román, Diego Alonso Quiroz-Marcelo, Diana Karina Común-Gutierrez, Diego Fernando Sanchez-Torres, Franz Jair Vera-Arias   +4 more
doaj   +1 more source

Non-aggregated Aβ25-35 Upregulates Primary Astrocyte Proliferation In Vitro

Frontiers in Cellular Neuroscience, 2017
Amyloid beta (Aβ) is a peptide cleaved from amyloid precursor protein that contributes to the formation of senile plaques in Alzheimer’s disease (AD). The relationship between Aβ and astrocyte proliferation in AD remains controversial.
Elise C. Ohki, Thomas J. Langan, Thomas J. Langan, Kyla R. Rodgers, Richard C. Chou, Richard C. Chou   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Olig2-Lineage Astrocytes: A Distinct Subtype of Astrocytes That Differs from GFAP Astrocytes [PDF]

Frontiers in Neuroanatomy, 2018
Astrocytes are the most abundant glia cell type in the central nervous system (CNS), and are known to constitute heterogeneous populations that differ in their morphology, gene expression and function. Although glial fibrillary acidic protein (GFAP) is the cardinal cytological marker of CNS astrocytes, GFAP-negative astrocytes can easily be found in ...
Kouko Tatsumi, Ayami Isonishi, Miwako Yamasaki, Yoshie Kawabe, Shoko Morita-Takemura, Kazuki Nakahara, Yuki Terada, Takeaki Shinjo, Hiroaki Okuda, Tatsuhide Tanaka, Akio Wanaka   +10 more
openaire   +3 more sources

Development and validation of an oxidative phosphorylation based prognostic model revealing tumor progression and immune microenvironment in lung adenocarcinoma

Discover Oncology
Background Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality worldwide. Although oxidative phosphorylation (OXPHOS) has been linked to tumor progression, its prognostic significance and underlying mechanisms in LUAD remain unclear ...
Hongxia Ma, Shaoshan Zeng, Changping Xie, Chengcheng Gao, Siao Jiang, Liuxin Chen, Wenhao Tian, Lizhi Huang   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

, 2015
Astrocytes are important regulatory elements in brain function. They respond to neurotransmitters and release gliotransmitters that modulate synaptic transmission.
Perea, Gertrudis, Araque, Alfonso, Martín Herranz, Ricardo, Moratalla, Rosario, Bajo Grañeras, Raquel   +4 more
core   +1 more source

Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

eLife, 2019
Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation of the CNS, including neuronal morphology and synapse refinement.
Leanne M Holt, Raymundo D Hernandez, Natasha L Pacheco, Beatriz Torres Ceja, Muhannah Hossain, Michelle L Olsen   +5 more
doaj   +1 more source

Versatile and simple approach to determine astrocyte territories in mouse neocortex and hippocampus. [PDF]

PLoS ONE, 2013
BACKGROUND: Besides their neuronal support functions, astrocytes are active partners in neuronal information processing. The typical territorial structure of astrocytes (the volume of neuropil occupied by a single astrocyte) is pivotal for many aspects ...
Antje Grosche, Jens Grosche, Mark Tackenberg, Dorit Scheller, Gwendolyn Gerstner, Annett Gumprecht, Thomas Pannicke, Petra G Hirrlinger, Ulrika Wilhelmsson, Kerstin Hüttmann, Wolfgang Härtig, Christian Steinhäuser, Milos Pekny, Andreas Reichenbach   +13 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source