Results 41 to 50 of about 133,591 (301)

Porosome in astrocytes [PDF]

Journal of Cellular and Molecular Medicine, 2009
AbstractSecretion is a universal cellular process occurring in bakers yeast, to the complex multicellular organisms, to humans beings. Neurotransmission, digestion, immune response or the release of hormones occur as a result of cell secretion. Secretory defects result in numerous diseases and hence a molecular understanding of the process is critical.
Lee, Jin-Sook, Cho, Won Jin, Jeftinija, Ksenija, Jeftinija, Srdija, Jena, Bhanu P   +4 more
openaire   +2 more sources

wzh7768/The-astrocyte-microglia-interaction-forms-a-feedback-loop-to-promote-epilepsy-in-TSC-patients: The astrocyte-microglia interaction forms a feedback loop to promote epilepsy in TSC patients

, 2023
The primary analysis in this article (The astrocyte-microglia interaction forms a feedback loop to promote epilepsy in TSC patients) is based on the code ...
Zhihao Wei
core   +1 more source

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels

Nature Communications, 2023
Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood.
Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya   +7 more
doaj   +1 more source

Astrocyte-Derived Lipocalin‑2 Is Involved in Mitochondrion-Related Neuronal Apoptosis Induced by Methamphetamine

, 2020
Methamphetamine (METH) is a widely abused and highly addictive psychoactive stimulant that can induce neuronal apoptosis. Lipocalin-2 (LCN2) is a member of the lipocalin family, and its upregulation is involved in cell death in the adult brain.
Xuebing Chen (708911), Huijun Wang (288634), Fu Zhang (4763397), Dongfang Qiao (7292756), Feng Qiu (496465), Jiancong Lu (7292750), Xiaohui Tan (654208), Chao Liu (43092), Chuanxiang Chen (7292753), Xu Zhao (133907), Jingtao Xu (1843699)   +10 more
core   +1 more source

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad   +17 more
core   +2 more sources

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

Frontiers in Physiology, 2019
The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes.
Susan Yu. Gordleeva, Anastasia V. Ermolaeva, Innokentiy A. Kastalskiy, Victor B. Kazantsev   +3 more
doaj   +1 more source

Astrocytic LMP2 Coordinates NF-κB and TGF-β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion. [PDF]

Adv Sci (Weinh)
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Mao Y, Ma R, Lin Z, Zhao H, Liu Y, Su Y, Zhang X, Chen X.   +7 more
europepmc   +2 more sources

Astrocytes and Aging [PDF]

Frontiers in Aging Neuroscience, 2018
By 2050, the aging population is predicted to expand by over 100%. Considering this rapid growth, and the additional strain it will place on healthcare resources because of age-related impairments, it is vital that researchers gain a deeper understanding of the cellular interactions that occur with normal aging.
Alexandra L. Palmer, Shalina S. Ousman, Shalina S. Ousman   +2 more
openaire   +3 more sources

FGFR3-TACC3 fusion as a potential primary resistance mechanism to EGFR-TKI in lung adenocarcinoma harboring co-driven mutations: a case report

Frontiers in Oncology
Oncogenic driver mutations were once considered mutually exclusive in non-small cell lung cancer (NSCLC), and the optimal management for these patients with co-mutations of driver genes remains controversial.
Xiuwen Wang, Liwen Qiu, Jizhen Liang, Fei Liu, Xiaoxue Ma, Pan Yang   +5 more
doaj   +1 more source

Astrocyte heterogeneity and interactions with local neural circuits [PDF]

, 2023
Astrocytes are ubiquitous within the central nervous system (CNS). These cells possess many individual processes which extend out into the neuropil, where they interact with a variety of other cell types, including neurons at synapses. Astrocytes are now
Holt, MG
core   +1 more source