Results 61 to 70 of about 172,284 (291)

UHPLC–electrospray ionization–mass spectrometric analysis of brain cell-specific glucogenic and neurotransmitter amino acid content

Scientific Reports, 2021
Astrocyte glycogen, the primary energy reserve in brain, undergoes continuous remodeling by glucose passage through the glycogen shunt prior to conversion to the oxidizable energy fuel l-lactate.
Khaggeswar Bheemanapally, Prabhat R. Napit, Mostafa M. H. Ibrahim, Karen P. Briski   +3 more
doaj   +1 more source

Tet1 Regulates Astrocyte Development and Cognition of Mice Through Modulating GluA1

Frontiers in Cell and Developmental Biology, 2021
Tet (Ten eleven translocation) family proteins-mediated 5-hydroxymethylcytosine (5hmC) is highly enriched in the neuronal system, and is involved in diverse biological processes and diseases.
Weize Xu, Weize Xu, Xicheng Zhang, Xicheng Zhang, Feng Liang, Yuhang Cao, Yuhang Cao, Yuhang Cao, Ziyi Li, Wenzheng Qu, Wenzheng Qu, Jinyu Zhang, Jinyu Zhang, Jinyu Zhang, Yanhua Bi, Chongran Sun, Jianmin Zhang, Binggui Sun, Qiang Shu, Qiang Shu, Xuekun Li, Xuekun Li, Xuekun Li   +22 more
doaj   +1 more source

Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow [PDF]

, 2019
We review modeling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering, where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural spiking.
A Destexhe, A Louveau, A R Gardner-Medwin, AJ Smith, AS Thrane, B Frankenhaeuser, B Lu, BJ Tully, BV Safronov, C Nicholson, C Silberstein, CL Lopreore, CS Furman, DD Wang, E Lothman, E Syková, EA Newman, EA Newman, EH Park, ER Kandel, G Cordingley, G Einevoll, G Florence, G Halnes, G Halnes, G Rutkowska, G Ullah, Geir Halnes, Geir Halnes, GG Somjen, GG Somjen, H Kager, H Kager, H Zhang, HD Lux, I Østby, I. Dietzel, J Keyser De, J Pods, J Sibille, J Tong, J Ziburkus, JC Vardakis, JJ Iliff, JONATHAN A. COLES, JS Jung, K Støverud, K. Baber, KC Chen, L Hertz, L Odette, L Xie, L Øyehaug, M Amiry-Moghaddam, M Bai, M Hashido, M Léonetti, M Nedergaard, MA Biot, Matti Hämäläinen, MS Jensen, N Hübel, N Kríz, N Macaulay, N Qian, NN Haj-Yasein, NN Haj-Yasein, P Kofuji, Paul L. Nunez, PM Nanninga, R Enger, RK Orkand, Rune Enger, SB Hladky, T Grisar, Tina Pangršič, Y Zhang   +76 more
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Extracellular regulated kinase 1/2 signaling is a critical regulator of interleukin-1β-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression.

PLoS ONE, 2013
Astrocytes are essential for proper central nervous system (CNS) function and are intricately involved in neuroinflammation. Despite evidence that immune-activated astrocytes contribute to many CNS pathologies, little is known about the inflammatory ...
Jerel Fields, Irma E Cisneros, Kathleen Borgmann, Anuja Ghorpade   +3 more
doaj   +1 more source

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e−\u3c/sup\u3e Mediates Aglycemic Neuronal Cell Death [PDF]

, 2015
The astrocyte cystine/glutamate antiporter (system xc−) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred.
He, Yan, Hewett, James A., Hewett, Sandra J., Jackman, Nicole A., Lobner, Doug, Thorn, Trista L.   +5 more
core   +1 more source

Brain edema : a valid endpoint for measuring hepatic encephalopathy? [PDF]

, 2016
Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease.
Bémeur, Chantal, Cooper, Arthur J. L., Cudalbu, Cristina, Dam, Gitte, Rose, Christopher, Thrane, Alexander S.   +5 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Astrocyte remodeling without gliosis precedes optic nerve axonopathy

Acta Neuropathologica Communications, 2018
Astroyctes serve myriad functions but are especially critical in white matter tracts, where energy-demanding axons propagate action potentials great distances between neurons.
Melissa L. Cooper, John W. Collyer, David J. Calkins   +2 more
doaj   +1 more source

Foreign body responses in central nervous system mimic natural wound responses and alter biomaterial functions [PDF]

, 2019
Biomaterials hold promise for diverse therapeutic applications in the central nervous system (CNS). Little is known about molecular factors that determine CNS foreign body responses (FBRs) in vivo , or about how such responses influence biomaterial ...
Ao, Yan, Deming, Timothy, Kim, Jae, O’Shea, Timothy, Sofroniew, Michael, Wollenberg, Alexander   +5 more
core   +1 more source