Results 71 to 80 of about 124,424 (305)

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling [PDF]

, 2015
The occurrence of cognitive disturbances upon CNS inflammation or infection has been correlated with increased levels of the cytokine tumor necrosis factor-α (TNFα).
Kollias, G., Santello, Mirko, Suter, T., Zappia, G., Santello, M., Stubbe, H., Volterra, A., Stubbe, Hiltrud, Fontana, Adriano, Pryce, Christopher R, Klaus, Federica R, Habbas, S., Liaudet, Nicolas, Klaus, Federica R., Becker, D., Fontana, A., Zappia, Giovanna, Habbas, Samia, Liaudet, N., Pryce, Christopher R., Klaus, F.R., Volterra, Andrea, Pryce, C.R., Becker, Denise, Kollias, George, Suter, Tobias   +25 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Astrocyte Calcium Signal and Gliotransmission in Human Brain Tissue

, 2012
Brain function is recognized to rely on neuronal activity and signaling processes between neurons, whereas astrocytes are generally considered to play supportive roles for proper neuronal function. However, accumulating evidence indicates that astrocytes
Perea, Gertrudis, Araque, Alfonso, García de Solá, Rafael, García de Sola, R., Maglio, Laura, Navarrete, Marta, Maglio, Laura Eva, Pastor, J., Pastor, Jesús   +8 more
core   +1 more source

Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective. [PDF]

, 2021
peer reviewedConverging evidence made clear that declining brain energetics contribute to aging and are implicated in the initiation and progression of neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
MULICA, Patrycja, GRÜNEWALD, Anne, Pereira, Sandro L.   +2 more
core   +1 more source

Extracellular regulated kinase 1/2 signaling is a critical regulator of interleukin-1β-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression.

PLoS ONE, 2013
Astrocytes are essential for proper central nervous system (CNS) function and are intricately involved in neuroinflammation. Despite evidence that immune-activated astrocytes contribute to many CNS pathologies, little is known about the inflammatory ...
Jerel Fields, Irma E Cisneros, Kathleen Borgmann, Anuja Ghorpade   +3 more
doaj   +1 more source

Enduring alterations in hippocampal astrocytesynaptic proximity following adolescent alcohol exposure: reversal by gabapentin

Neural Regeneration Research, 2020
Adolescent alcohol abuse is a substantive public health problem that has been the subject of intensive study in recent years. Despite reports of a wide range of effects of adolescent intermittent ethanol (AIE) exposure on brain and behavior, little is ...
Kati L Healey, Sandra Kibble, Sierra Hodges, Kathryn J Reissner, Anze Testen, Tiffany A Wills, Shawn K Acheson, Benjamin M Siemsen, John A McFaddin, Michael D Scofield, H Scott Swartzwelder   +10 more
doaj   +1 more source

PPARα Inhibits Astrocyte Inflammation Activation by Restoring Autophagic Flux after Transient Brain Ischemia

Biomedicines, 2023
Astrocyte inflammation activation is an important cause that hinders the recovery of motor function after cerebral ischemia. However, its molecular mechanism has not yet been clearly clarified.
Doudou Luo, Wenxuan Ye, Ling Chen, Xiaoqian Yuan, Yali Zhang, Caixia Chen, Xin Jin, Yu Zhou   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Astrocyte remodeling without gliosis precedes optic nerve axonopathy

Acta Neuropathologica Communications, 2018
Astroyctes serve myriad functions but are especially critical in white matter tracts, where energy-demanding axons propagate action potentials great distances between neurons.
Melissa L. Cooper, John W. Collyer, David J. Calkins   +2 more
doaj   +1 more source