Results 31 to 40 of about 16,006 (273)
THE CAJAL SCHOOL AND THE PHYSIOLOGICAL ROLE OF ASTROCYTES: A WAY OF THINKING
Frontiers in Neuroanatomy, 2014 Cajal is widely recognized by the scientific community for his important contributions to our knowledge of the neuronal organization of the nervous system.
Marta eNavarrete +2 more
doaj +1 more source
The role of glial cells in neurodegenerative diseases. Part 1. Characteristics and physiological functions [PDF]
Farmacja Polska, 2022 The nervous system is composed of two dominant types of cells – neurons and glial cells. They differ from each other both morphologically and physiologically.
Mateusz Maszczyk +2 more
doaj +1 more source
Studying neurodegenerative diseases in culture models
Brazilian Journal of Psychiatry, 2013 Neurodegenerative diseases are pathological conditions that have an insidious onset and chronic progression. Different models have been established to study these diseases in order to understand their underlying mechanisms and to investigate new ...
Johannes C.M. Schlachetzki +2 more
doaj +1 more source
Chinese Journal of Physiology, 2022 Epoxyeicosatrienoic acids (EETs) are fatty acid signaling molecules synthesized by cytochrome P450 epoxygenases from arachidonic acid. The biological activity of EETs is terminated when being metabolized by soluble epoxide hydrolase (sEH), a process that
Yi-Min Kuo, Yi-Hsuan Lee
doaj +1 more source
Neuroimmune Regulation of Surgery-Associated Metastases
Cells, 2021 Surgery remains an essential therapeutic approach for most solid malignancies. Although for more than a century accumulating clinical and experimental data have indicated that surgical procedures themselves may promote the appearance and progression of ...
Michael R. Shurin +2 more
doaj +1 more source
Editorial: Neuroglia Molecular Mechanisms in Psychiatric Disorders [PDF]
Frontiers in Molecular Neuroscience, 2018 Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and ...
Caterina Scuderi +4 more
doaj +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source