Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death [PDF]
Journal of Neuroinflammation, 2010 Background We previously found that cyclooxygenase 2 (COX-2) was expressed in dying oligodendrocytes at the onset of demyelination in the Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) model of multiple sclerosis (MS ...
Rojas Monica A +6 more
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Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration
Frontiers in Cell and Developmental Biology, 2021 In the central nervous system, oligodendrocytes produce myelin sheaths that enwrap neuronal axons to provide trophic support and increase conduction velocity.
Ethan G Hughes, Hughes Ethan G
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Oligodendrocytes in Development, Myelin Generation and Beyond
Cells, 2019 Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the CNS and represent a pool of migratory and proliferative adult progenitor ...
Sarah Kuhn +2 more
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Secretome analysis of human oligodendrocytes derived from neural stem cells.
PLoS ONE, 2014 In this study, we investigated the secretome of human oligodendrocytes (F3.Olig2 cells) generated from human neural stem cells by transduction with the gene encoding the Olig2 transcription factor.
Woo Kyung Kim +7 more
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GAT‐1 mediated GABA uptake in rat oligodendrocytes [PDF]
Glia, 2017 Stimulated by the results of a recent paper on the effects of tiagabine, a selective inhibitor of the main GABA transporter GAT-1, on oligodendrogenesis, we verified the possibility that GAT-1 may be expressed in oligodendrocytes using immunocytochemical
Giorgia Fattorini +2 more
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Tim‐2 is the receptor for H‐ferritin on oligodendrocytes
Journal of Neurochemistry, 2008 Oligodendrocytes stain more strongly for iron than any other cell in the CNS, and they require iron for the production of myelin. For most cell types transferrin is the major iron delivery protein, yet neither transferrin receptor protein nor mRNA are ...
W E Seaman, James R Connor
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SHP-2 promotes the maturation of oligodendrocyte precursor cells through Akt and ERK1/2 signaling in vitro. [PDF]
PLoS ONE, 2011 BACKGROUND: Oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes (OLs), which are responsible for myelination. Myelin is essential for saltatory nerve conduction in the vertebrate nervous system. However, the molecular mechanisms of
Xiujie Liu +8 more
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Nogo-A aggravates oxidative damage in oligodendrocytes
Neural Regeneration Research, 2021 Nogo-A is considered one of the most important inhibitors of myelin-associated axonal regeneration in the central nervous system. It is mainly expressed by oligodendrocytes.
Yang-Yang Wang +3 more
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REDOX Balance in Oligodendrocytes Is Important for Zebrafish Visual System Regeneration
Antioxidants, 2023 Zebrafish (Danio rerio) present continuous growth and regenerate many parts of their body after an injury. Fish oligodendrocytes, microglia and astrocytes support the formation of new connections producing effective regeneration of the central nervous ...
Cristina Pérez-Montes +5 more
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Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. [PDF]
PLoS ONE, 2017 Oligodendrocytes myelinate axons and form myelin sheaths in the central nervous system. The development of therapies for demyelinating diseases, including multiple sclerosis and leukodystrophies, is a challenge because the pathogenic mechanisms of ...
Tomoko Yamashita +12 more
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