Results 21 to 30 of about 69,674 (261)

Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex

Cell Reports, 2019
Summary: Reciprocal communication between neurons and oligodendrocytes is essential for the generation and localization of myelin, a critical feature of the CNS.
Marzieh Zonouzi, Daniel Berger, Vahbiz Jokhi, Amanda Kedaigle, Jeff Lichtman, Paola Arlotta   +5 more
doaj   +1 more source

Cx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling

Neurobiology of Disease, 2011
In addition to the extensive gap junction coupling between astrocytes themselves, oligodendrocytes are thought to be exclusively coupled to astrocytes (O:A coupling) via heterotypic gap junctions composed of Cx47:Cx43 and Cx32:Cx30.
Sameh K. Wasseff, Steven S. Scherer
doaj   +1 more source

Developmental stage of oligodendrocytes determines their response to activated microglia in vitro

Journal of Neuroinflammation, 2007
Background Oligodendrocyte progenitor cells (OPCs) and mature oligodendrocytes are both lost in central nervous system injury and disease. Activated microglia may play a role in OPC and oligodendrocyte loss or replacement, but it is not clear how the ...
Bresnahan Jacqueline C, Ferguson Adam R, Tovar C Amy, Crum Jeannine M, Miller Brandon A, Beattie Michael S   +5 more
doaj   +1 more source

BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy

Acta Neuropathologica Communications, 2020
Multiple system atrophy (MSA) is pathologically characterized by the presence of fibrillar α-synuclein-immunoreactive inclusions in oligodendrocytes. Although the myelinating process of oligodendrocytes can be observed in adult human brains, little is ...
Seiji Kaji, Takakuni Maki, Jun Ueda, Tomoyuki Ishimoto, Yutaka Inoue, Ken Yasuda, Masanori Sawamura, Rie Hikawa, Takashi Ayaki, Hodaka Yamakado, Ryosuke Takahashi   +10 more
doaj   +1 more source

Fatty Acid Binding Protein 5 Mediates Cell Death by Psychosine Exposure through Mitochondrial Macropores Formation in Oligodendrocytes

Biomedicines, 2020
Oligodendrocytes, the myelinating cells in the central nervous system (CNS), are critical for producing myelin throughout the CNS. The loss of oligodendrocytes is associated with multiple neurodegenerative disorders mediated by psychosine.
An Cheng, Ichiro Kawahata, Kohji Fukunaga   +2 more
doaj   +1 more source

Histone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells. [PDF]

PLoS ONE, 2013
In X-ALD, mutation/deletion of ALD gene (ABCD1) and the resultant very long chain fatty acid (VLCFA) derangement has dramatically opposing effects in astrocytes and oligodendrocytes.
Jaspreet Singh, Mushfiquddin Khan, Aurora Pujol, Mauhamad Baarine, Inderjit Singh   +4 more
doaj   +1 more source

Secretome analysis of human oligodendrocytes derived from neural stem cells.

PLoS ONE, 2014
In this study, we investigated the secretome of human oligodendrocytes (F3.Olig2 cells) generated from human neural stem cells by transduction with the gene encoding the Olig2 transcription factor.
Woo Kyung Kim, Deokhoon Kim, Jun Cui, Ho Hee Jang, Kwang Sei Kim, Hong Jun Lee, Seung U Kim, Sung-Min Ahn   +7 more
doaj   +1 more source

Dystrophy of Oligodendrocytes and Adjacent Microglia in Prefrontal Gray Matter in Schizophrenia

Frontiers in Psychiatry, 2020
BackgroundSome evidence support the notion that microglia activation in acute state of schizophrenia might contribute to damage of oligodendrocytes and myelinated fibers.
Natalya A. Uranova, Olga V. Vikhreva, Valentina I. Rakhmanova, Diana D. Orlovskaya   +3 more
doaj   +1 more source

Evidence for Cooperative Selection of Axons for Myelination by Adjacent Oligodendrocytes in the Optic Nerve. [PDF]

PLoS ONE, 2016
The cellular mechanisms that regulate the topographic arrangement of myelin internodes along axons remain largely uncharacterized. Recent clonal analysis of oligodendrocyte morphologies in the mouse optic nerve revealed that adjacent oligodendrocytes ...
Darragh M Walsh, Tobias D Merson, Kerry A Landman, Barry D Hughes   +3 more
doaj   +1 more source

Mechanosensitivity of Human Oligodendrocytes [PDF]

Frontiers in Cellular Neuroscience, 2020
Oligodendrocytes produce and repair myelin, which is critical for the integrity and function of the central nervous system (CNS). Oligodendrocyte and oligodendrocyte progenitor cell (OPC) biology is modulated in vitro by mechanical cues within the magnitudes observed in vivo.
Daniela Espinosa-Hoyos, Suzanne R. Burstein, Jaaram Cha, Tanya Jain, Madhura Nijsure, Anna Jagielska, Anna Jagielska, Valentina Fossati, Krystyn J. Van Vliet, Krystyn J. Van Vliet, Krystyn J. Van Vliet   +10 more
openaire   +3 more sources