Results 21 to 30 of about 81,187 (302)

Demyelination and oligodendrocytes

Rinsho Shinkeigaku, 2011
Although neurological sequelae are attributable to poor regeneration of the central nervous system, oligodendrocytes demonstrate robust regenerative response even in adults. Accumulating evidence indicates that the glial cells identified by surface expression of the proteoglycan NG2 are the cellular source of newly-developed oligodendrocytes following ...
Itoh, Takayuki, Horiuchi, Makoto, Wakayama, Kouji, Itoh, Aki, Pleasure, David   +4 more
openaire   +3 more sources

Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE

Journal of Neuroinflammation, 2019
Background Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS.
Yuan Yue, Milos Stanojlovic, Yifeng Lin, Gerard Karsenty, Wensheng Lin   +4 more
doaj   +1 more source

Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]

, 2014
In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Raineteau, Olivier, Fischer, Bruno,, Sommer, Lukas, Sommer, Lukas,, Draganova, Kalina,, Draganova, Kalina, Fischer, Bruno, Cantu, Claudio, Azim, Kasum,, Butt, Arthur, Raineteau, Olivier,, Butt, Arthur,, Azim, Kasum, Hurtado-Chong, Anahi,, Hurtado-Chong, Anahi, Cantù, Claudio,, Zemke, Martina, Zemke, Martina,   +17 more
core   +1 more source

Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions.

PLoS ONE, 2017
Within the microenvironment of multiple sclerosis lesions, oligodendrocytes are subject to metabolic stress reflecting effects of focal ischemia and inflammation.
Vijayaraghava T S Rao, Damla Khan, Qiao-Ling Cui, Shih-Chieh Fuh, Shireen Hossain, Guillermina Almazan, Gerhard Multhaup, Luke M Healy, Timothy E Kennedy, Jack P Antel   +9 more
doaj   +1 more source

TASK-1 channels in oligodendrocytes: A role in ischemia mediated disruption

Neurobiology of Disease, 2013
Oligodendrocytes are the myelinating cells of the CNS and, like neurons, are highly sensitive to ischemic damage. However, the mechanisms underlying cytotoxicity in oligodendrocytes during hypoxic/ischemic episodes are not fully understood. TASK-1 is a K+
Virginia Hawkins, Arthur Butt
doaj   +1 more source

Direct association with the vascular basement membrane is a frequent feature of myelinating oligodendrocytes in the neocortex

Fluids and Barriers of the CNS, 2023
Background Oligodendrocyte lineage cells interact with the vasculature in the gray matter. Physical and functional interactions between blood vessels and oligodendrocyte precursor cells play an essential role in both the developing and adult brain ...
Justine S. C. Palhol, Maddalena Balia, Fernando Sánchez-Román Terán, Mélody Labarchède, Etienne Gontier, Arne Battefeld   +5 more
doaj   +1 more source

Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex

Cell Reports, 2019
Summary: Reciprocal communication between neurons and oligodendrocytes is essential for the generation and localization of myelin, a critical feature of the CNS.
Marzieh Zonouzi, Daniel Berger, Vahbiz Jokhi, Amanda Kedaigle, Jeff Lichtman, Paola Arlotta   +5 more
doaj   +1 more source

Disease-Associated Oligodendrocyte: New Player in Alzheimer's Disease and CNS Pathologies

Journal of Integrative Neuroscience, 2023
Considerable evidence has shown that the breakdown of myelin has been linked to Alzheimer’s disease (AD). Considering the vulnerability of oligodendrocytes to Alzheimer’s disease, the myelin sheath breakdown and degeneration are easily induced ...
Peng Chen, ZhiLei Guo, Benhong Zhou
doaj   +1 more source

Developmental stage of oligodendrocytes determines their response to activated microglia in vitro

Journal of Neuroinflammation, 2007
Background Oligodendrocyte progenitor cells (OPCs) and mature oligodendrocytes are both lost in central nervous system injury and disease. Activated microglia may play a role in OPC and oligodendrocyte loss or replacement, but it is not clear how the ...
Bresnahan Jacqueline C, Ferguson Adam R, Tovar C Amy, Crum Jeannine M, Miller Brandon A, Beattie Michael S   +5 more
doaj   +1 more source

BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy

Acta Neuropathologica Communications, 2020
Multiple system atrophy (MSA) is pathologically characterized by the presence of fibrillar α-synuclein-immunoreactive inclusions in oligodendrocytes. Although the myelinating process of oligodendrocytes can be observed in adult human brains, little is ...
Seiji Kaji, Takakuni Maki, Jun Ueda, Tomoyuki Ishimoto, Yutaka Inoue, Ken Yasuda, Masanori Sawamura, Rie Hikawa, Takashi Ayaki, Hodaka Yamakado, Ryosuke Takahashi   +10 more
doaj   +1 more source