Results 21 to 30 of about 88,496 (298)

Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions.

PLoS ONE, 2017
Within the microenvironment of multiple sclerosis lesions, oligodendrocytes are subject to metabolic stress reflecting effects of focal ischemia and inflammation.
Vijayaraghava T S Rao, Damla Khan, Qiao-Ling Cui, Shih-Chieh Fuh, Shireen Hossain, Guillermina Almazan, Gerhard Multhaup, Luke M Healy, Timothy E Kennedy, Jack P Antel   +9 more
doaj   +1 more source

TASK-1 channels in oligodendrocytes: A role in ischemia mediated disruption

Neurobiology of Disease, 2013
Oligodendrocytes are the myelinating cells of the CNS and, like neurons, are highly sensitive to ischemic damage. However, the mechanisms underlying cytotoxicity in oligodendrocytes during hypoxic/ischemic episodes are not fully understood. TASK-1 is a K+
Virginia Hawkins, Arthur Butt
doaj   +1 more source

Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex

Cell Reports, 2019
Summary: Reciprocal communication between neurons and oligodendrocytes is essential for the generation and localization of myelin, a critical feature of the CNS.
Marzieh Zonouzi, Daniel Berger, Vahbiz Jokhi, Amanda Kedaigle, Jeff Lichtman, Paola Arlotta   +5 more
doaj   +1 more source

Disease-Associated Oligodendrocyte: New Player in Alzheimer's Disease and CNS Pathologies

Journal of Integrative Neuroscience, 2023
Considerable evidence has shown that the breakdown of myelin has been linked to Alzheimer’s disease (AD). Considering the vulnerability of oligodendrocytes to Alzheimer’s disease, the myelin sheath breakdown and degeneration are easily induced ...
Peng Chen, ZhiLei Guo, Benhong Zhou
doaj   +1 more source

Developmental stage of oligodendrocytes determines their response to activated microglia in vitro

Journal of Neuroinflammation, 2007
Background Oligodendrocyte progenitor cells (OPCs) and mature oligodendrocytes are both lost in central nervous system injury and disease. Activated microglia may play a role in OPC and oligodendrocyte loss or replacement, but it is not clear how the ...
Bresnahan Jacqueline C, Ferguson Adam R, Tovar C Amy, Crum Jeannine M, Miller Brandon A, Beattie Michael S   +5 more
doaj   +1 more source

Multiple Restricted Origin of Oligodendrocytes

, 1998
Theplpgene encodes the proteolipid protein and its alternatively spliced product DM-20, major proteins of CNS myelin. In the mouse,plp/dm-20transcripts are expressed beginning at embryonic day 9.5 (E9.5) by restricted foci of germinative neuroepithelial ...
N. Spassky, I. Cerruti, J.-L. Thomas, B. Zalc, C. Olivier, E. Parmantier, A. Ivanova, C. Goujet-Zalc, K. Ikenaka, S. Martinez, W. Macklin   +10 more
core   +2 more sources

BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy

Acta Neuropathologica Communications, 2020
Multiple system atrophy (MSA) is pathologically characterized by the presence of fibrillar α-synuclein-immunoreactive inclusions in oligodendrocytes. Although the myelinating process of oligodendrocytes can be observed in adult human brains, little is ...
Seiji Kaji, Takakuni Maki, Jun Ueda, Tomoyuki Ishimoto, Yutaka Inoue, Ken Yasuda, Masanori Sawamura, Rie Hikawa, Takashi Ayaki, Hodaka Yamakado, Ryosuke Takahashi   +10 more
doaj   +1 more source

Cx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling

Neurobiology of Disease, 2011
In addition to the extensive gap junction coupling between astrocytes themselves, oligodendrocytes are thought to be exclusively coupled to astrocytes (O:A coupling) via heterotypic gap junctions composed of Cx47:Cx43 and Cx32:Cx30.
Sameh K. Wasseff, Steven S. Scherer
doaj   +1 more source

Fatty Acid Binding Protein 5 Mediates Cell Death by Psychosine Exposure through Mitochondrial Macropores Formation in Oligodendrocytes

Biomedicines, 2020
Oligodendrocytes, the myelinating cells in the central nervous system (CNS), are critical for producing myelin throughout the CNS. The loss of oligodendrocytes is associated with multiple neurodegenerative disorders mediated by psychosine.
An Cheng, Ichiro Kawahata, Kohji Fukunaga   +2 more
doaj   +1 more source

Mature oligodendrocytes actively increase in vivo [PDF]

, 2015
BACKGROUND Oligodendrocytes are myelinating cells of the central nervous system which support functionally, structurally, and metabolically neurons.
Ari Waisman, Pushpalatha Palle, Schreiner, Bettina, Burkhard Becher, Becher, B, Schreiner, B, Buch, Thorsten, Becher, Burkhard, Thorsten Buch, Buch, T, Palle, Pushpalatha, Palle, P, Baggiolini, Arianna, Waisman, Ari, Giuseppe Locatelli, Waisman, A, Locatelli, Giuseppe, Bettina Schreiner, Baggiolini, A, Locatelli, G, Arianna Baggiolini, Schreiner B, Baggiolini A, Locatelli G, Waisman A, Becher B, Buch T, Locatelli, Giuseppe;Baggiolini, Arianna;Schreiner, Bettina;Palle, Pushpalatha;Waisman, Ari;Becher, Burkhard;Buch, Thorsten, Palle P   +28 more
core   +2 more sources