Results 1 to 10 of about 19,675 (119)
Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination [PDF]
Nature CommunicationsAging accelerates central nervous system remyelination failure and neurodegeneration. Microglia promote remyelination by phagocytosing myelin debris, but this function is impaired by aging-related CD22 upregulation.
Weixing Yan +27 more
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Life Science Alliance, 2022 PRMT1 regulates MHC-associated microglia cluster during de/remyelination. Remyelination failure in multiple sclerosis leads to progressive demyelination and inflammation, resulting in neurodegeneration and clinical decline.
Jeesan Lee +6 more
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Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration
Frontiers in Molecular Neuroscience, 2023 Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains over the past decade with many regeneration strategies undergoing tested in
Davin Packer +2 more
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Microglia promote remyelination independent of their role in clearing myelin debris
Cell Reports, 2023 Summary: Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination.
Charbel S. Baaklini +17 more
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In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis
eLife, 2023 Remyelination is crucial to recover from inflammatory demyelination in multiple sclerosis (MS). Investigating remyelination in vivo using magnetic resonance imaging (MRI) is difficult in MS, where collecting serial short-interval scans is challenging ...
Maxime Donadieu +14 more
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Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis
Frontiers in Molecular Neuroscience, 2022 Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). In people with MS, impaired remyelination and axonal loss lead to debilitating long-term neurologic deficits.
Marjan Gharagozloo +3 more
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eLife, 2016 Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss.
Feng Mei +16 more
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Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model
Cells, 2020 To unravel the failure of remyelination in multiple sclerosis (MS) and to test promising remyelinating treatments, suitable animal models like the well-established cuprizone model are required. However, this model is only standardized in young mice. This
Stefan Gingele +7 more
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Cell Reports, 2021 Summary: In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated lesions contributes to axonal damage and clinical disability.
Kimberle Shen +9 more
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A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
PLoS ONE, 2021 Incomplete remyelination is frequent in multiple sclerosis (MS)-lesions, but there is no established marker for recent remyelination. We investigated the role of the oligodendrocyte/myelin protein ermin in de- and remyelination in the cuprizone (CPZ ...
Intakhar Ahmad +3 more
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