Results 1 to 10 of about 22,271 (244)
Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases
MedComm, Volume 7, Issue 6, June 2026.Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu +9 more
wiley +1 more source
Organoids: From Bench to Bedside Applications
MedComm, Volume 7, Issue 6, June 2026.Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
Systemic TLR2 tolerance enhances central nervous system remyelination
Journal of Neuroinflammation, 2019 Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination.
Nicholas J. Wasko +9 more
doaj +1 more source
Newly Identified Deficiencies in the Multiple Sclerosis Central Nervous System and Their Impact on the Remyelination Failure [PDF]
, 2022 Giuseppe Scalabrino
openalex +1 more source
MedComm, Volume 7, Issue 6, June 2026.APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina +5 more
wiley +1 more source
Senescent-like microglia limit remyelination through the senescence associated secretory phenotype
Nature CommunicationsThe capacity to regenerate myelin in the central nervous system diminishes with age. This decline is particularly evident in multiple sclerosis (MS), a chronic demyelinating disease.
Phillip S. Gross +14 more
doaj +1 more source
Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3396-3408, June 2026.ABSTRACT Purpose To evaluate the correspondence between myelin water fraction (MWF) estimates derived from multi‐echo spin echo (MESE) and multi‐echo gradient echo (MGRE) imaging in fixed mouse brain tissue, using a panel of myelin basic protein (Mbp) enhancer‐edited mouse lines exhibiting graded hypomyelination.
Vladimir Grouza +11 more
wiley +1 more source
Dicer deficiency affects microglial function during demyelination and impairs remyelination
Neurobiology of DiseaseMicroglia are essential regulators of central nervous system (CNS) homeostasis, playing key roles in demyelination and remyelination. Dysregulated microglial activity contributes to pathological inflammation and impaired repair processes in demyelinating
Ajai Tripathi +7 more
doaj +1 more source
Microglia contributes to remyelination in cerebral but not spinal cord ischemia [PDF]
, 2021 Goran Pavic +12 more
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Deferoxamine Improves Radiation‐Induced Peripheral Neuropathy
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Radiation‐induced peripheral neuropathy (RIPN) is a devastating sequela of radiation therapy (XRT). Current treatment options are limited. Deferoxamine (DFO) has been useful in treating radiation‐induced dermal fibrosis. This study aimed to evaluate DFO for RIPN. Thus, 18 mice received 30Gy of fractionated XRT.
Christopher V. Lavin +12 more
wiley +1 more source