Results 1 to 10 of about 34,938 (236)

Age-impaired remyelination is associated with dysregulated microglial transitions [PDF]

Nature Communications
Multiple sclerosis (MS) is a chronic, inflammatory condition characterized by neurodegeneration and lost myelin, or demyelination. This lost myelin may be regenerated in people with MS through a process called remyelination, that is prone to failure and ...
Sameera Zia, Marianela E. Traetta, Charbel S. Baaklini, Brady P. Hammond, Rebecca K. John, Katherine M. Souter, Niels Meijns, Larry K. A. Afun, Sharmistha Panda, Fernando González Ibáñez, Mena K. Burr, Eva Dhupia, Abhisha M. Rathod, Andre O. Faria, Dhruvish Zaveri, Sowmya Challa, Eugene Hahn, Sohrab B. Manesh, Kelly V. Lee, Madelene F. S. Ho, Timothy N. Friedman, Aislinn D. Maguire, Arina Pang, Olivia Farkas, Bożena Szulc, Luiz Tenorio, Diya Vyas, Olivia R. La Caprara, Wolfram Tetzlaff, Sarthak Sinha, Gregory J. Duncan, Anastassia Voronova, Bradley J. Kerr, Marie-Eve Tremblay, Jeff Biernaskie, Geert Schenk, Jason R. Plemel   +36 more
doaj   +2 more sources

PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system

Life Science Alliance, 2022
PRMT1 regulates MHC-associated microglia cluster during de/remyelination. Remyelination failure in multiple sclerosis leads to progressive demyelination and inflammation, resulting in neurodegeneration and clinical decline.
Jeesan Lee, Oscar David Villarreal, Yu Chang Wang, Jiannis Ragoussis, Serge Rivest, David Gosselin, Stéphane Richard   +6 more
doaj   +1 more source

Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration

Frontiers in Molecular Neuroscience, 2023
Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains over the past decade with many regeneration strategies undergoing tested in
Davin Packer, Emily E. Fresenko, Em P. Harrington   +2 more
doaj   +1 more source

Microglia promote remyelination independent of their role in clearing myelin debris

Cell Reports, 2023
Summary: Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination.
Charbel S. Baaklini, Madelene F.S. Ho, Tristan Lange, Brady P. Hammond, Sharmistha P. Panda, Martin Zirngibl, Sameera Zia, Kassandre Himmelsbach, Heli Rana, Braxton Phillips, Daria Antoszko, Jeremies Ibanga, Mizuki Lopez, Kelly V. Lee, Michael B. Keough, Andrew V. Caprariello, Bradley J. Kerr, Jason R. Plemel   +17 more
doaj   +1 more source

In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis

eLife, 2023
Remyelination is crucial to recover from inflammatory demyelination in multiple sclerosis (MS). Investigating remyelination in vivo using magnetic resonance imaging (MRI) is difficult in MS, where collecting serial short-interval scans is challenging ...
Maxime Donadieu, Nathanael J Lee, María I Gaitán, Seung-Kwon Ha, Nicholas J Luciano, Snehashis Roy, Benjamin Ineichen, Emily C Leibovitch, Cecil C Yen, Dzung L Pham, Afonso C Silva, Mac Johnson, Steve Jacobson, Pascal Sati, Daniel S Reich   +14 more
doaj   +1 more source

Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis

Frontiers in Molecular Neuroscience, 2022
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). In people with MS, impaired remyelination and axonal loss lead to debilitating long-term neurologic deficits.
Marjan Gharagozloo, Jackson W. Mace, Peter A. Calabresi, Peter A. Calabresi   +3 more
doaj   +1 more source

Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination [PDF]

, 2017
Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage.
Bramlett, Brück, Brück, Clark, Cunningham, Foote, Fünfschilling, Gudi, Hiremath, Hiremath, Irvine, Irvine, Kornek, Kuhlmann, Kutzelnigg, Lassmann, Lassmann, Lee, Lindner, Lindner, Lucchinetti, Manrique-Hoyos, Mason, Matsushima, McKenzie, Mildner, Morrison, Murray, Nikic, Otsuka, Patrikios, Pierce, Schuh, Simons, Singh, Skripuletz, Sorbara, Stidworthy, Trapp   +38 more
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Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

eLife, 2016
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss.
Feng Mei, Klaus Lehmann-Horn, Yun-An A Shen, Kelsey A Rankin, Karin J Stebbins, Daniel S Lorrain, Kara Pekarek, Sharon A Sagan, Lan Xiao, Cory Teuscher, H-Christian von Büdingen, Jürgen Wess, J Josh Lawrence, Ari J Green, Stephen PJ Fancy, Scott S Zamvil, Jonah R Chan   +16 more
doaj   +1 more source

Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination

Cell Reports, 2021
Summary: In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated lesions contributes to axonal damage and clinical disability.
Kimberle Shen, Mike Reichelt, Roxanne V. Kyauk, Hai Ngu, Yun-An A. Shen, Oded Foreman, Zora Modrusan, Brad A. Friedman, Morgan Sheng, Tracy J. Yuen   +9 more
doaj   +1 more source

Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination [PDF]

, 2018
Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD).
Pasquini, Laura Andrea, Thomas, Laura
core   +1 more source