Results 11 to 20 of about 26,726 (251)

Hedgehog Signaling in CNS Remyelination

Cells, 2022
Remyelination is a fundamental repair process in the central nervous system (CNS) that is triggered by demyelinating events. In demyelinating diseases, oligodendrocytes (OLs) are targeted, leading to myelin loss, axonal damage, and severe functional ...
Minxi Fang, Tao Tang, Mengsheng Qiu, Xiaofeng Xu   +3 more
doaj   +5 more sources

Regenerative Capacity of Macrophages for Remyelination [PDF]

Frontiers in Cell and Developmental Biology, 2016
White matter injury, consisting of loss of axons, myelin and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative myelin sheath is
Khalil eRawji, Manoj eMishra, V Wee eYong   +2 more
doaj   +4 more sources

EEF1A1 deacetylation enables transcriptional activation of remyelination [PDF]

Nature Communications, 2020
The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and ...
Mert Duman, Adrien Vaquié, Gianluigi Nocera, Manfred Heller, Michael Stumpe, Devanarayanan Siva Sankar, Jörn Dengjel, Dies Meijer, Teppei Yamaguchi, Patrick Matthias, Thomas Zeis, Nicole Schaeren-Wiemers, Antoinette Hayoz, Sophie Ruff, Claire Jacob   +14 more
doaj   +4 more sources

Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination [PDF]

eLife
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyelinated lesions
Amber R Philp, Carolina R Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao, Carlos Valenzuela-Krugmann, Khalil S Rawji, Ginez A Gonzalez Martinez, Penelope Dimas, Bryan Hinrichsen, César Ulloa-Leal, Amie K Waller, Diana M Bessa de Sousa, Maite A Castro, Ludwig Aigner, Pamela Ehrenfeld, Maria Elena Silva, Ilias Kazanis, Cedric Ghevaert, Robin JM Franklin, Francisco J Rivera   +20 more
doaj   +7 more sources

Glia Disease and Repair—Remyelination [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, although this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granular neurons, the same is not true of its glial elements.
Franklin, Robin J M, Goldman, Steven A
openaire   +4 more sources

Remyelination protects neurons from DLK-mediated neurodegeneration [PDF]

Nature Communications
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration of neurons and their connections that drives progressive disability in demyelinating disease.
Greg J. Duncan, Sam D. Ingram, Katie Emberley, Jo Hill, Christian Cordano, Ahmed Abdelhak, Michael McCane, Jennifer E. Jenks, Nora Jabassini, Kirtana Ananth, Skylar J. Ferrara, Brittany Stedelin, Benjamin Sivyer, Sue A. Aicher, Thomas S. Scanlan, Trent A. Watkins, Anusha Mishra, Jonathan W. Nelson, Ari J. Green, Ben Emery   +19 more
doaj   +2 more sources

CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents [PDF]

Nature Communications
In Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore fast saltatory conduction and neuroprotection but is inefficient in MS especially ...
Laura J. Wagstaff, Nadine Bestard-Cuche, Maja Kaczmarek, Antonella Fidanza, Lorraine McNeil, Robin J. M. Franklin, Anna C. Williams   +6 more
doaj   +9 more sources

Antibody mediated neutralization of myelin associated EphrinB3 accelerates CNS remyelination [PDF]

, 2015
Remyelination in multiple sclerosis (MS) lesions often remains incomplete despite the presence of oligodendrocyte progenitor cells (OPCs). Amongst other factors, successful remyelination depends on the phagocytic clearance of myelin debris.
Syed, Yasir A, Foss, Franziska, Lilley, Kathryn, Aycan Sentürk, Franklin, Robin J M, Nave, Klaus-A, Sentürk, Aycan, Syed, Y., Sentürk, A., Lubec, G., Kotter, Mark R. N., Möbius, W., Zhao, C., Nave, Klaus-A., Acker-Palmer, Amparo, Wiebke Möbius, Friedrich Altmann, Don Mahad, Kotter, M., Yasir A. Syed, Franklin, R., Altmann, Friedrich, Kotter , M., Sentuerk, Aycan, Lilley, K., Zhao, Chao, Gert Lubec, Robin J. M. Franklin, Mahad, Don, Acker-Palmer, A., González, G., Möbius, Wiebke, Foss, F., Lubec, Gert, Nave, K., Kathryn Lilley, Franziska Foss, Mark R. N. Kotter, Kotter, Mark R N, Altmann, F., Amparo Acker-Palmer, Syed, Yasir A., Klaus-A. Nave, Franklin, Robin J. M., Chao Zhao, Mahad, D.   +45 more
core   +9 more sources

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities [PDF]

, 2022
Remyelination, the myelin regenerative response that follows demyelination, restores saltatory conduction and function and sustains axon health. Its declining efficiency with disease progression in the chronic autoimmune disease multiple sclerosis (MS ...
Simons, Mikael, Franklin, Robin J. M.
core   +1 more source

Remyelination Trials [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2021
Neuroaxonal loss is believed to underpin the progressive disability that characterizes multiple sclerosis (MS). While focal inflammatory demyelination is a principal cause of acute axonal transection and subsequent axonal degeneration, the gradual attrition of permanently demyelinated axons may also contribute to tissue damage, particularly in the ...
Klistorner, Alexandr, Barnett, Michael
openaire   +2 more sources