Results 11 to 20 of about 25,880 (231)

Hedgehog Signaling in CNS Remyelination

Cells, 2022
Remyelination is a fundamental repair process in the central nervous system (CNS) that is triggered by demyelinating events. In demyelinating diseases, oligodendrocytes (OLs) are targeted, leading to myelin loss, axonal damage, and severe functional ...
Minxi Fang, Tao Tang, Mengsheng Qiu, Xiaofeng Xu   +3 more
doaj   +5 more sources

Regenerative Capacity of Macrophages for Remyelination [PDF]

Frontiers in Cell and Developmental Biology, 2016
White matter injury, consisting of loss of axons, myelin and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative myelin sheath is
Khalil eRawji, Manoj eMishra, V Wee eYong   +2 more
doaj   +4 more sources

Remyelination Therapy in Multiple Sclerosis

Frontiers in Neurology, 2015
Multiple Sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration.
Danielle E. Harlow, Justin eHonce, Augusto A. Miravalle   +2 more
doaj   +2 more sources

Regulation of remyelination in multiple sclerosis [PDF]

FEBS Letters, 2011
Multiple sclerosis is a common demyelinating disease that worsens over the course of disease, a significant problem in clinical management. Disability in MS is significantly promoted by poor repair and remyelination of lesions. Both oligodendrocyte recruitment and maturation defects are seen as major causes of poor remyelination in MS.
Hanafy, Khalid A., Sloane, Jacob A.
openaire   +3 more sources

EEF1A1 deacetylation enables transcriptional activation of remyelination [PDF]

Nature Communications, 2020
The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and ...
Mert Duman, Adrien Vaquié, Gianluigi Nocera, Manfred Heller, Michael Stumpe, Devanarayanan Siva Sankar, Jörn Dengjel, Dies Meijer, Teppei Yamaguchi, Patrick Matthias, Thomas Zeis, Nicole Schaeren-Wiemers, Antoinette Hayoz, Sophie Ruff, Claire Jacob   +14 more
doaj   +4 more sources

A New Model of Cuprizone-Mediated Demyelination/Remyelination

ASN Neuro, 2014
In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs, Kathryn K. Bercury, Daniela C. Popescu, S. Priya Narayanan, Wendy B. Macklin   +4 more
doaj   +2 more sources

Remyelination protects neurons from DLK-mediated neurodegeneration [PDF]

Nature Communications
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration of neurons and their connections that drives progressive disability in demyelinating disease.
Greg J. Duncan, Sam D. Ingram, Katie Emberley, Jo Hill, Christian Cordano, Ahmed Abdelhak, Michael McCane, Jennifer E. Jenks, Nora Jabassini, Kirtana Ananth, Skylar J. Ferrara, Brittany Stedelin, Benjamin Sivyer, Sue A. Aicher, Thomas S. Scanlan, Trent A. Watkins, Anusha Mishra, Jonathan W. Nelson, Ari J. Green, Ben Emery   +19 more
doaj   +2 more sources

Glia Disease and Repair—Remyelination [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, although this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granular neurons, the same is not true of its glial elements.
Franklin, Robin J M, Goldman, Steven A
openaire   +4 more sources

Region Specific miRNA-mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Sapra A, Rai NK, Niepokny TD, Courtney H, Tripathi A, Dutta R.   +5 more
europepmc   +2 more sources

Antibody mediated neutralization of myelin associated EphrinB3 accelerates CNS remyelination [PDF]

, 2015
Remyelination in multiple sclerosis (MS) lesions often remains incomplete despite the presence of oligodendrocyte progenitor cells (OPCs). Amongst other factors, successful remyelination depends on the phagocytic clearance of myelin debris.
Syed, Yasir A, Foss, Franziska, Lilley, Kathryn, Aycan Sentürk, Franklin, Robin J M, Nave, Klaus-A, Sentürk, Aycan, Syed, Y., Sentürk, A., Lubec, G., Kotter, Mark R. N., Möbius, W., Zhao, C., Nave, Klaus-A., Acker-Palmer, Amparo, Wiebke Möbius, Friedrich Altmann, Don Mahad, Kotter, M., Yasir A. Syed, Franklin, R., Altmann, Friedrich, Kotter , M., Sentuerk, Aycan, Lilley, K., Zhao, Chao, Gert Lubec, Robin J. M. Franklin, Mahad, Don, Acker-Palmer, A., González, G., Möbius, Wiebke, Foss, F., Lubec, Gert, Nave, K., Kathryn Lilley, Franziska Foss, Mark R. N. Kotter, Kotter, Mark R N, Altmann, F., Amparo Acker-Palmer, Syed, Yasir A., Klaus-A. Nave, Franklin, Robin J. M., Chao Zhao, Mahad, D.   +45 more
core   +11 more sources