Results 11 to 20 of about 19,756 (195)
Hedgehog Signaling in CNS Remyelination
Cells, 2022 Remyelination is a fundamental repair process in the central nervous system (CNS) that is triggered by demyelinating events. In demyelinating diseases, oligodendrocytes (OLs) are targeted, leading to myelin loss, axonal damage, and severe functional ...
Minxi Fang +3 more
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Neurology Neuroimmunology & Neuroinflammation, 2021 Neuroaxonal loss is believed to underpin the progressive disability that characterizes multiple sclerosis (MS). While focal inflammatory demyelination is a principal cause of acute axonal transection and subsequent axonal degeneration, the gradual attrition of permanently demyelinated axons may also contribute to tissue damage, particularly in the ...
Klistorner, Alexandr, Barnett, Michael
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Remyelination Therapy in Multiple Sclerosis
Frontiers in Neurology, 2015 Multiple Sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration.
Danielle E. Harlow +2 more
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A New Model of Cuprizone-Mediated Demyelination/Remyelination
ASN Neuro, 2014 In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs +4 more
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Neurobiology of Disease, 2008 Osteopontin (OPN) is a key immunoregulator in the autoimmune-mediated demyelinating disease multiple sclerosis. OPN may also play a role in the remyelination since it is 1) a ligand for αV integrins, several of which regulate the properties of the ...
Chao Zhao +3 more
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Brain region dependent molecular signatures and myelin repair following chronic demyelination
Frontiers in Cellular Neuroscience, 2023 Multiple sclerosis (MS) is the most prevalent demyelinating disease of the central nervous system, characterized by myelin destruction, axonal degeneration, and progressive loss of neurological functions.
Grace Samtani +8 more
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Routes of precursors' migration in remyelination. [PDF]
BrainAbstract Remyelination, the biological process of restoring myelin sheaths, is critically dependent on the successful recruitment of oligodendrocyte lineage cells. However, this process involves at least two functionally distinct endogenous reservoirs: the widely distributed parenchymal oligodendrocyte precursor cells (pOPCs) and ...
Ghareghani M, Ghorbani S.
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Frontiers in ImmunologyObjectiveNeuropsychiatric systemic lupus erythematosus (NPSLE) is among the most challenging manifestations of systemic lupus erythematosus (SLE), affecting the central and peripheral nervous systems with diverse symptoms.
Karim Matmat +10 more
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Pharmaceuticals, 2021 Inflammatory attacks and demyelination in the central nervous system (CNS) are the key factors responsible for the damage of neurons in multiple sclerosis (MS).
Viktoria Gudi +4 more
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Astrocytes in myelination and remyelination
Neuroscience Letters, 2019 Astrocytes are known to play critical roles in central nervous system development, homeostasis, and response to injury. In addition to well-defined functions in synaptic signalling and blood-brain barrier control, astrocytes are now emerging as important contributors to white matter health.
Irene Molina-Gonzalez +1 more
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