Results 11 to 20 of about 22,271 (244)
The Role of Astrocytes in Remyelination [PDF]
Trends in Neurosciences, 2020 Remyelination is the regeneration of myelin sheaths following demyelination. This regenerative process is critical for the re-establishment of axonal conduction velocity and metabolic support to the axons. Successful remyelination in the CNS generally depends on the activation, proliferation, and differentiation of oligodendrocyte progenitor cells ...
Khalil S Rawji, Robin J M Franklin
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Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells [PDF]
Frontiers in Molecular Neuroscience, 2019 In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that surrounds axons, a process known as demyelination. The spontaneous regeneration of myelin, called remyelination, is associated with restoration of function and ...
Charbel S. Baaklini +4 more
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Cell Reports, 2021 Summary: In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated lesions contributes to axonal damage and clinical disability.
Mike Reichelt, Hai Ngu, Oded Foreman
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Remyelination in multiple sclerosis
Journal of the Neurological Sciences, 2003 Remyelination in multiple sclerosis (MS) lesions has been described in several studies. It depends on the presence of myelinating oligodendrocytes and a functional interaction between these myelinating cells and axons. The imaging signal of remyelination in magnetic resonance imaging or spectroscopy is not yet defined.
Tanja Kuhlmann, Christine Stadelmann
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Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination [PDF]
Nature CommunicationsAging accelerates central nervous system remyelination failure and neurodegeneration. Microglia promote remyelination by phagocytosing myelin debris, but this function is impaired by aging-related CD22 upregulation.
Weixing Yan +27 more
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Activation of oligodendroglial Stat3 is required for efficient remyelination
Neurobiology of Disease, 2016 Multiple sclerosis is the most prevalent demyelinating disease of the central nervous system (CNS) and is histologically characterized by perivascular demyelination as well as neurodegeneration.
Andrew J. Steelman +6 more
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Regenerative Capacity of Macrophages for Remyelination [PDF]
Frontiers in Cell and Developmental Biology, 2016 White matter injury, consisting of loss of axons, myelin and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative myelin sheath is
Khalil eRawji +2 more
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Routes of precursors’ migration in remyelination [PDF]
BrainAbstract Remyelination, the biological process of restoring myelin sheaths, is critically dependent on the successful recruitment of oligodendrocyte lineage cells. However, this process involves at least two functionally distinct endogenous reservoirs: the widely distributed parenchymal oligodendrocyte precursor cells (pOPCs) and ...
Majid Ghareghani, Samira Ghorbani
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Evoked potentials as a biomarker of remyelination [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Remyelination is a critical therapeutic target in MS that will restore function and protect demyelinated axons. Clinical trials of putative remyelination-promoting drugs depend on valid, robust, and noninvasive outcome measures.
Moones Heidari +2 more
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Hedgehog Signaling in CNS Remyelination
Cells, 2022 Remyelination is a fundamental repair process in the central nervous system (CNS) that is triggered by demyelinating events. In demyelinating diseases, oligodendrocytes (OLs) are targeted, leading to myelin loss, axonal damage, and severe functional ...
Minxi Fang +3 more
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