Results 1 to 10 of about 5,891 (192)

An Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model [PDF]

ASN Neuro, 2017
The cuprizone model is a well-established and investigated paradigm to study demyelination and remyelination in rodents. Cuprizone is usually administrated by mixing in the powdered or pelleted rodent chow.
Wandong Zhang, Ailian Liu
exaly   +3 more sources

Treadmill Exercise Impact on Brain Electrophysiological and Glial Immunoreactivity in Cuprizone-Treated Rats [PDF]

Brain Sciences
Background/Objectives: Demyelination occurs to a variable extent in various neurological diseases, such as multiple sclerosis. Physical exercise benefits central neural functions that depend on the brain’s electrophysiological and glial activity.
Cássia Borges Lima-de-Castro, Noranege Epifânio Accioly, Geórgia de Sousa Ferreira Soares, Catarina Nicácio dos-Santos, Sonia Carolina Guerrero Prieto, Rubem Carlos Araujo Guedes   +5 more
doaj   +4 more sources

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry. [PDF]

Angew Chem Int Ed Engl
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Zhang C, Michael JA, Teo JD, Song H, Westerhausen MT, Mutuku SM, Ellis SR, Don AS.   +7 more
europepmc   +3 more sources

Growth Differentiation Factor 11 Is a Circulating Regulator of Oligodendrocyte Differentiation and CNS Myelin Formation and Repair. [PDF]

CNS Neurosci Ther
Systemically administered GDF11 enhances CNS myelin formation and repair across both developmental and disease contexts. GDF11 promotes the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes, increases myelin sheath thickness in neonatal mice, and accelerates remyelination in both the cuprizone‐induced demyelination model ...
Zhang Z, Yan M, Huang W, Chen Y, Lv T, Chen W.   +5 more
europepmc   +2 more sources

Depletion of Microglia Increases Cortical Oligodendrocyte Density During Remyelination. [PDF]

Glia
Cuprizone demyelination induces transient reactive states in deep cortical microglia (MG) through early recovery. Depleting MG in recovery increases the number of deep cortical mature/pre‐myelinating oligodendrocytes. Deep cortical reactive MG reduce oligodendrocyte density after demyelination.
Loo HK, Gallegos J, Mialki C, Perrin GE, Malloy T, Orthmann-Murphy JL.   +5 more
europepmc   +2 more sources

Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression. [PDF]

Arch Pharm (Weinheim)
Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Rychlik N, Jüngling K, Meuth SG, Budde T, Méndez-Couz M.   +4 more
europepmc   +2 more sources

Effect of transplanted oligodendrocyte precursor cells derived from inflammatory and non-inflammatory microenvironment on remyelination in a chronic cuprizone model. [PDF]

PLoS ONE
IntroductionMultiple sclerosis is a chronic demyelinating disease of the central nervous system. Transplantation of oligodendrocyte progenitor cells (OPCs) is a promising approach to enhance remyelination; however, the influence of the OPCs ...
Hoda Akbari, Iraj Ragerdi-Kashani, Farzaneh Rezaei-Yazdi, Parichehr Pasbakhsh   +3 more
doaj   +2 more sources

Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone -induced multiple sclerosis model. [PDF]

PLoS ONE
Multiple sclerosis (MS) is characterized by chronic neuroinflammation and progressive demyelination, with current therapies failing to adequately address both processes simultaneously.
Aliakbar Mariki, Kristi Anne Kohlmeier, Seyed Mohammad Mousavi, Alireza Keyhani, Majid Fasihi Harandi, Mansoureh Sabzalizadeh, Mohammad Shabani   +6 more
doaj   +2 more sources

Cortico-hippocampal molecular characterization in rat model of multiple sclerosis: Neuroprotective mechanisms of oil [PDF]

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Background Current multiple sclerosis management primarily targets symptom alleviation and immune modulation, with limited success in halting progression or achieving sustained remission.
Rhoda Mama Kolo, Chijoke Bethel Ehirim, Damilola Opeadua Olabiyi, Isaac Ayobami Ayobamidele, Rukayat Jaji-Sulaimon, Gabriel Olaiya Omotoso   +5 more
doaj   +2 more sources

Effect of swimming on oligodendrocytic cells and myelin tissue in corpus callosum of rat model of MS induced by Cuprizone [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021
Background: Multiple Sclerosis is a myelin destroyer disease, which physical activity can be effective in improving it. Therefore, in the present study, the effect of swimming on oligodendrocytic cells and myelin tissue in rat brain of the Cuprizone ...
Ebrahim Bagheri, Sayed Mohammad Marandi, Nazem Ghasemi, Zeinab Rezaee   +3 more
doaj   +1 more source