Molecular Neurodegeneration, 2022 Background The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis.
Martin Zirngibl +2 more
exaly +2 more sources
An Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model
ASN Neuro, 2017 The cuprizone model is a well-established and investigated paradigm to study demyelination and remyelination in rodents. Cuprizone is usually administrated by mixing in the powdered or pelleted rodent chow.
Wandong Zhang
exaly +2 more sources
Effect of transplanted oligodendrocyte precursor cells derived from inflammatory and non-inflammatory microenvironment on remyelination in a chronic cuprizone model. [PDF]
PLoS ONEIntroductionMultiple sclerosis is a chronic demyelinating disease of the central nervous system. Transplantation of oligodendrocyte progenitor cells (OPCs) is a promising approach to enhance remyelination; however, the influence of the OPCs ...
Hoda Akbari +3 more
doaj +2 more sources
Treadmill Exercise Impact on Brain Electrophysiological and Glial Immunoreactivity in Cuprizone-Treated Rats [PDF]
Brain SciencesBackground/Objectives: Demyelination occurs to a variable extent in various neurological diseases, such as multiple sclerosis. Physical exercise benefits central neural functions that depend on the brain’s electrophysiological and glial activity.
Cássia Borges Lima-de-Castro +5 more
doaj +2 more sources
Cortico-hippocampal molecular characterization in rat model of multiple sclerosis: Neuroprotective mechanisms of oil [PDF]
Multiple Sclerosis Journal - Experimental, Translational and ClinicalBackground Current multiple sclerosis management primarily targets symptom alleviation and immune modulation, with limited success in halting progression or achieving sustained remission.
Rhoda Mama Kolo +5 more
doaj +2 more sources
Melatonin ameliorates astrogliosis and microgliosis in a cuprizone demyelinating mouse model [PDF]
Biochemistry and Biophysics ReportsBackground and purpose: Several investigations have reported that melatonin is involved in the amelioration of the inflammatory process, improvement of myelin function, and regeneration in the central nervous system (CNS).
Mehdi Alidadi +5 more
doaj +2 more sources
Effect of swimming on oligodendrocytic cells and myelin tissue in corpus callosum of rat model of MS induced by Cuprizone [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021 Background: Multiple Sclerosis is a myelin destroyer disease, which physical activity can be effective in improving it. Therefore, in the present study, the effect of swimming on oligodendrocytic cells and myelin tissue in rat brain of the Cuprizone ...
Ebrahim Bagheri +3 more
doaj +1 more source
Cuprizone feed formulation influences the extent of demyelinating disease pathology
Scientific Reports, 2021 Cuprizone is a copper-chelating agent that induces pathology similar to that within some multiple sclerosis (MS) lesions. The reliability and reproducibility of cuprizone for inducing demyelinating disease pathology depends on the animals ingesting ...
Lillian M. Toomey +9 more
doaj +1 more source
NeuroImage, 2022 Disruptions in oxidative metabolism may occur in multiple sclerosis and other demyelinating neurological diseases. The impact of demyelination on metabolic rate is also not understood.
Mada Hashem +4 more
doaj +1 more source
Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis. [PDF]
PLoS ONE, 2015 Previous studies on the degenerative animal model of multiple sclerosis suggested that the copper-chelator cuprizone might directly suppress T-cell functions.
Izabella Solti +10 more
doaj +1 more source