A New Model of Cuprizone-Mediated Demyelination/Remyelination
ASN Neuro, 2014 In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Wendy Macklin, Daniela C Popescu
exaly +5 more sources
Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice
Brain Sciences, 2022 Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis.
Kelly F. Paton +3 more
doaj +3 more sources
Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis. [PDF]
PLoS ONE, 2015 Previous studies on the degenerative animal model of multiple sclerosis suggested that the copper-chelator cuprizone might directly suppress T-cell functions.
Izabella Solti +10 more
doaj +3 more sources
Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone -induced multiple sclerosis model. [PDF]
PLoS ONEMultiple sclerosis (MS) is characterized by chronic neuroinflammation and progressive demyelination, with current therapies failing to adequately address both processes simultaneously.
Aliakbar Mariki +6 more
doaj +2 more sources
Effect of transplanted oligodendrocyte precursor cells derived from inflammatory and non-inflammatory microenvironment on remyelination in a chronic cuprizone model. [PDF]
PLoS ONEIntroductionMultiple sclerosis is a chronic demyelinating disease of the central nervous system. Transplantation of oligodendrocyte progenitor cells (OPCs) is a promising approach to enhance remyelination; however, the influence of the OPCs ...
Hoda Akbari +3 more
doaj +2 more sources
Effect of swimming on oligodendrocytic cells and myelin tissue in corpus callosum of rat model of MS induced by Cuprizone [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021 Background: Multiple Sclerosis is a myelin destroyer disease, which physical activity can be effective in improving it. Therefore, in the present study, the effect of swimming on oligodendrocytic cells and myelin tissue in rat brain of the Cuprizone ...
Ebrahim Bagheri +3 more
doaj +1 more source
Cortico-hippocampal molecular characterization in rat model of multiple sclerosis: Neuroprotective mechanisms of oil [PDF]
Multiple Sclerosis Journal - Experimental, Translational and ClinicalBackground Current multiple sclerosis management primarily targets symptom alleviation and immune modulation, with limited success in halting progression or achieving sustained remission.
Rhoda Mama Kolo +5 more
doaj +2 more sources
Evaluation of the Role of Growth Hormone Against Cuprizone Induced Multiple Sclerosis in the Cerebellar Cortex of Adult Female Albino Rat (Histological, Immunohistochemical and Radiological Study) [PDF]
The Egyptian Journal of Histology, 2023 Introduction: Multiple sclerosis (MS) is a primary demyelinating disease which is more common in females in the third and fourth decades of life. The cerebellum is a predilection site for lesion development in MS.
Enas Bekheet, Mohamed Sonbol
doaj +1 more source
Cuprizone feed formulation influences the extent of demyelinating disease pathology
Scientific Reports, 2021 Cuprizone is a copper-chelating agent that induces pathology similar to that within some multiple sclerosis (MS) lesions. The reliability and reproducibility of cuprizone for inducing demyelinating disease pathology depends on the animals ingesting ...
Lillian M. Toomey +9 more
doaj +1 more source
NeuroImage, 2022 Disruptions in oxidative metabolism may occur in multiple sclerosis and other demyelinating neurological diseases. The impact of demyelination on metabolic rate is also not understood.
Mada Hashem +4 more
doaj +1 more source