Results 21 to 30 of about 6,317 (193)
Cuprizone Intoxication Results in Myelin Vacuole Formation [PDF]
Frontiers in Cellular Neuroscience, 2022 Myelin damage is a histopathological hallmark of multiple sclerosis lesions. Results of post mortem studies suggest that impaired myelin-axon interaction characterized by focal myelin detachments is an early event during lesion genesis. In this study, we
Sarah Joost +8 more
doaj +3 more sources
Acta Neuropathologica, 2009 Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects the central nervous system and represents the most common neurological disorder in young adults in the Western hemisphere. There are several well-characterized experimental animal models that allow studying potential mechanisms of MS pathology.
Kipp, Markus +4 more
core +4 more sources
Cells, 2020 In the present study, we investigated the effects of cuprizone on cell death, glial activation, and neuronal plasticity induced by hypothermia after ischemia in gerbils. Food was supplemented with cuprizone at 0.2% ad libitum for eight weeks.
Woosuk Kim +11 more
doaj +2 more sources
Dietary vitamin D3 supplements reduce demyelination in the cuprizone model. [PDF]
PLoS ONE, 2011 Vitamin D is emerging as a probably important environmental risk factor in multiple sclerosis, affecting both susceptibility and disease progression. It is not known to what extent this effect is due to a modulation of peripheral lymphocyte function, or ...
Stig Wergeland +5 more
doaj +3 more sources
P2x7 receptors control demyelination and inflammation in the cuprizone model [PDF]
Brain, Behavior, & Immunity - Health, 2020 The contribution of P2x7 receptors to multiple sclerosis remains controversial, as both detrimental and beneficial effects resulting from P2x7 receptor loss-of-function have been reported in autoimmune models of the disease. Here we investigated the relevance of P2x7 receptors to de- and remyelination in the cuprizone model of T cell-independent myelin
Ana Bernal-Chico +5 more
openaire +5 more sources
Brain SciencesBackground/Objectives: Demyelination occurs to a variable extent in various neurological diseases, such as multiple sclerosis. Physical exercise benefits central neural functions that depend on the brain’s electrophysiological and glial activity.
Cássia Borges Lima-de-Castro +5 more
doaj +2 more sources
GAS6 Enhances Repair Following Cuprizone-Induced Demyelination
PLoS ONE, 2010 Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of cell types, including cells of the central nervous system (CNS). In this study, we tested the hypothesis that administration of recombinant human Gas6 (rhGas6) protein ...
Vladislav Tsiperson +4 more
openaire +5 more sources
Cells, 2019 Brain volume measurement is one of the most frequently used biomarkers to establish neuroprotective effects during pre-clinical multiple sclerosis (MS) studies.
Tanja Hochstrasser +9 more
doaj +2 more sources
Multifaceted response of microglia in the cuprizone model of demyelination. [PDF]
PLoS OneThe cuprizone diet paradigm, which involves selective depletion of oligodendrocytes and subsequent myelin loss, provides an excellent model to study the neuroimmune response to demyelination and remyelination. Microglia, the resident
Shanahan A +3 more
europepmc +2 more sources
Oligodendrocyte and Astrocyte Dynamics During Short-Term Cuprizone Treatment. [PDF]
Brain BehavEarly cuprizone exposure (3 days to 1 week) results in the loss of mature oligodendrocytes and a shift in astrocyte subtypes before overt demyelination occurs. A1 astrocytes remained non‐significant; however, A2 astrocytes increased, indicating a protective, pro‐repair astrocyte–oligodendrocyte interaction that may be crucial for therapeutic ...
Frankle L +10 more
europepmc +2 more sources