Results 21 to 30 of about 6,444 (163)

Oligodendrocyte and Astrocyte Dynamics During Short-Term Cuprizone Treatment. [PDF]

Brain Behav
Early cuprizone exposure (3 days to 1 week) results in the loss of mature oligodendrocytes and a shift in astrocyte subtypes before overt demyelination occurs. A1 astrocytes remained non‐significant; however, A2 astrocytes increased, indicating a protective, pro‐repair astrocyte–oligodendrocyte interaction that may be crucial for therapeutic ...
Frankle L, Oso M, Riley A, Tomor R, Checan DC, Lee H, Jarzembak K, Sternbach S, Shelestak J, McDonough J, Clements R.   +10 more
europepmc   +2 more sources

Development and validation of a novel HILIC method for the quantification of low-levels of cuprizone in cuprizone-containing chow

Scientific Reports, 2021
Cuprizone is an amide compound that has been wildly used in various animal studies, such as in the investigation of remyelination in mouse model. It is important to control the amount of cuprizone dosed in animals to be consistent as different amounts ...
Fengmei Zheng, Yiqing Lin, Pierre Boulas
doaj   +1 more source

Visual Evoked Potentials to Monitor Myelin Cuprizone-Induced Functional Changes

Frontiers in Neuroscience, 2022
The visual system is one of the most accessible routes to study the central nervous system under pathological conditions, such as in multiple sclerosis (MS).
Silvia Marenna, Su-Chun Huang, Gloria Dalla Costa, Gloria Dalla Costa, Raffaele d’Isa, Valerio Castoldi, Elena Rossi, Giancarlo Comi, Giancarlo Comi, Letizia Leocani, Letizia Leocani   +10 more
doaj   +1 more source

Cuprizone Affects Hypothermia-Induced Neuroprotection and Enhanced Neuroblast Differentiation in the Gerbil Hippocampus after Ischemia

Cells, 2020
In the present study, we investigated the effects of cuprizone on cell death, glial activation, and neuronal plasticity induced by hypothermia after ischemia in gerbils. Food was supplemented with cuprizone at 0.2% ad libitum for eight weeks.
Woosuk Kim, Kyu Ri Hahn, Hyo Young Jung, Hyun Jung Kwon, Sung Min Nam, Tae Hyeong Kim, Jong Whi Kim, Dae Young Yoo, Dae Won Kim, Jung Hoon Choi, Yeo Sung Yoon, In Koo Hwang   +11 more
doaj   +1 more source

Cuprizone Intoxication Results in Myelin Vacuole Formation

Frontiers in Cellular Neuroscience, 2022
Myelin damage is a histopathological hallmark of multiple sclerosis lesions. Results of post mortem studies suggest that impaired myelin-axon interaction characterized by focal myelin detachments is an early event during lesion genesis. In this study, we
Sarah Joost, Felix Schweiger, Friederike Pfeiffer, Carolin Ertl, Jonas Keiler, Marcus Frank, Marcus Frank, Markus Kipp, Markus Kipp   +8 more
doaj   +1 more source

Table_1_Visual Evoked Potentials to Monitor Myelin Cuprizone-Induced Functional Changes.DOCX

, 2022
The visual system is one of the most accessible routes to study the central nervous system under pathological conditions, such as in multiple sclerosis (MS).
Su-Chun Huang (11833853), Giancarlo Comi (223051), Silvia Marenna (12420535), Gloria Dalla Costa (7235855), Valerio Castoldi (12420541), Letizia Leocani (2839559), Raffaele d’Isa (12420538), Elena Rossi (25722)   +7 more
core   +1 more source

Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats [PDF]

, 2018
Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum.Methods: Twenty adult ...
Ameen, M.O., Omotoso, G.O., Akinlolu, A.A., Lawal, M.O., Kolo, R.M., Gbadamosi, I.T., Lewu, S.F., Adunmo, G.O., Kadir, R.E.   +8 more
core   +1 more source

Cuprizone feeding induces swollen astrocyte endfeet

, 2022
The cuprizone model is a widely used model to study the pathogenesis of multiple sclerosis (MS). Due to the selective loss of mature oligodendrocytes and myelin, it is mainly being used to study demyelination and the mechanisms of remyelination, as well ...
Fallier-Becker, Petra, Bonzheim, Irina, Pfeiffer, Friederike   +2 more
core   +1 more source

Effects of calcitriol and fingolimod on remyelination in the cuprizone model [PDF]

, 2020
Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, and neurodegeneration of the central nervous system (CNS). There is no cure. Current treatments target the autoimmune aspects of MS but do not directly improve CNS
Nystad, Agnes Elisabeth
core   +1 more source

Melatonin ameliorates cuprizone‐induced reduction of hippocampal neurogenesis, brain‐derived neurotrophic factor, and phosphorylation of cyclic AMP response element‐binding protein in the mouse dentate gyrus

Brain and Behavior, 2019
Introduction The aim of this study was to investigate the effects of cuprizone on adult hippocampal neurogenesis in naïve mice. Additionally, we also studied how melatonin affects the neuronal degeneration induced by cuprizone.
Woosuk Kim, Kyu Ri Hahn, Hyo Young Jung, Hyun Jung Kwon, Sung Min Nam, Jong Whi Kim, Joon Ha Park, Dae Young Yoo, Dae Won Kim, Moo‐Ho Won, Yeo Sung Yoon, In Koo Hwang   +11 more
doaj   +1 more source