Results 21 to 30 of about 8,969 (212)
PLoS ONE, 2020 The cuprizone induced animal model of demyelination is characterized by demyelination in many regions of the brain with high levels of demyelination in the corpus callosum as well as changes in neuronal function by 4-6 weeks of exposure.
John Shelestak +7 more
doaj +1 more source
Cells, 2020 In the present study, we investigated the effects of cuprizone on cell death, glial activation, and neuronal plasticity induced by hypothermia after ischemia in gerbils. Food was supplemented with cuprizone at 0.2% ad libitum for eight weeks.
Woosuk Kim +11 more
doaj +1 more source
Visual Evoked Potentials to Monitor Myelin Cuprizone-Induced Functional Changes
Frontiers in Neuroscience, 2022 The visual system is one of the most accessible routes to study the central nervous system under pathological conditions, such as in multiple sclerosis (MS).
Silvia Marenna +10 more
doaj +1 more source
Exogenous Leukemia Inhibitory Factor Stimulates Oligodendrocyte Progenitor Cell Proliferation and Enhances Hippocampal Remyelination [PDF]
, 2012 New CNS neurons and glia are generated throughout adulthood from endogenous neural stem and progenitor cells. These progenitors can respond to injury, but their ability to proliferate, migrate, differentiate, and survive is usually insufficient to ...
Deverman, Benjamin E. +1 more
core +1 more source
Frontiers in Behavioral Neuroscience, 2010 Recent human studies suggest a role for altered oligodendrocytes in the pathophysiology of schizophrenia. Our recent animal study has reported some schizophrenia-like behaviors in mice exposed to cuprizone (Xu et al., 2009), a copper chelator that has ...
Haiyun Xu +4 more
doaj +1 more source
Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination [PDF]
, 2018 Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD).
Pasquini, Laura Andrea, Thomas, Laura
core +1 more source
Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination [PDF]
, 2017 Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage.
Bramlett +38 more
core +1 more source
Mechanisms involved in the remyelinating effect of sildenafil [PDF]
, 2018 Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease.
Díaz-Lucena, Daniela +5 more
core +1 more source
TREM2 sustains microglial expansion during aging and response to demyelination [PDF]
, 2015 Microglia contribute to development, homeostasis, and immunity of the CNS. Like other tissue-resident macrophage populations, microglia express the surface receptor triggering receptor expressed on myeloid cells 2 (TREM2), which binds polyanions, such as
Colonna, Marco +6 more
core +1 more source
Frontiers in Molecular Neuroscience, 2021 Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are ...
Ana Caroline Brambilla Falvella +12 more
doaj +1 more source