Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice [PDF]
Brain Sciences, 2022 Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis.
Kelly F. Paton +3 more
doaj +4 more sources
Increased blood-brain barrier hyperpermeability coincides with mast cell activation early under cuprizone administration. [PDF]
PLoS ONE, 2020 The cuprizone induced animal model of demyelination is characterized by demyelination in many regions of the brain with high levels of demyelination in the corpus callosum as well as changes in neuronal function by 4-6 weeks of exposure.
John Shelestak +7 more
doaj +2 more sources
Cuprizone Intoxication Results in Myelin Vacuole Formation [PDF]
Frontiers in Cellular Neuroscience, 2022 Myelin damage is a histopathological hallmark of multiple sclerosis lesions. Results of post mortem studies suggest that impaired myelin-axon interaction characterized by focal myelin detachments is an early event during lesion genesis. In this study, we
Sarah Joost +8 more
doaj +3 more sources
Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis. [PDF]
PLoS ONE, 2015 Previous studies on the degenerative animal model of multiple sclerosis suggested that the copper-chelator cuprizone might directly suppress T-cell functions.
Izabella Solti +10 more
doaj +4 more sources
Cuprizone Affects Hypothermia-Induced Neuroprotection and Enhanced Neuroblast Differentiation in the Gerbil Hippocampus after Ischemia [PDF]
Cells, 2020 In the present study, we investigated the effects of cuprizone on cell death, glial activation, and neuronal plasticity induced by hypothermia after ischemia in gerbils. Food was supplemented with cuprizone at 0.2% ad libitum for eight weeks.
Woosuk Kim +11 more
doaj +2 more sources
Dietary vitamin D3 supplements reduce demyelination in the cuprizone model. [PDF]
PLoS ONE, 2011 Vitamin D is emerging as a probably important environmental risk factor in multiple sclerosis, affecting both susceptibility and disease progression. It is not known to what extent this effect is due to a modulation of peripheral lymphocyte function, or ...
Stig Wergeland +5 more
doaj +4 more sources
GAS6 Enhances Repair Following Cuprizone-Induced Demyelination [PDF]
PLoS ONE, 2010 Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of cell types, including cells of the central nervous system (CNS). In this study, we tested the hypothesis that administration of recombinant human Gas6 (rhGas6) protein ...
Vladislav Tsiperson +4 more
openaire +5 more sources
P2x7 receptors control demyelination and inflammation in the cuprizone model [PDF]
Brain, Behavior, & Immunity - Health, 2020 The contribution of P2x7 receptors to multiple sclerosis remains controversial, as both detrimental and beneficial effects resulting from P2x7 receptor loss-of-function have been reported in autoimmune models of the disease. Here we investigated the relevance of P2x7 receptors to de- and remyelination in the cuprizone model of T cell-independent myelin
Ana Bernal-Chico +5 more
openaire +6 more sources
Stereological Investigation of Regional Brain Volumes after Acute and Chronic Cuprizone-Induced Demyelination [PDF]
Cells, 2019 Brain volume measurement is one of the most frequently used biomarkers to establish neuroprotective effects during pre-clinical multiple sclerosis (MS) studies.
Tanja Hochstrasser +9 more
doaj +2 more sources
Evaluation of the Role of Growth Hormone Against Cuprizone Induced Multiple Sclerosis in the Cerebellar Cortex of Adult Female Albino Rat (Histological, Immunohistochemical and Radiological Study) [PDF]
The Egyptian Journal of Histology, 2023 Introduction: Multiple sclerosis (MS) is a primary demyelinating disease which is more common in females in the third and fourth decades of life. The cerebellum is a predilection site for lesion development in MS.
Enas Bekheet, Mohamed Sonbol
doaj +1 more source