Results 31 to 40 of about 8,969 (212)

Myelin copper and the cuprizone model of schizophrenia [PDF]

Frontiers in Bioscience, 2011
In recent years increasing evidence is pointing toward white matter abnormalities in schizophrenia and other psychiatric disorders. The present paper will provide an overview over the role of myelin in cognition and brain function, and its potential involvement in brain disorders.
Nicole R, Herring, Christine, Konradi
openaire   +2 more sources

Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination [PDF]

The Journal of Neuroscience, 2020
Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a copper chelator, is widely used to study demyelination and remyelination in the CNS, in the context of MS. However, the mechanisms underlying oligodendrocyte (OL) cell loss and demyelination are not known.
Priya Jhelum, Eva Santos-Nogueira, Wulin Teo, Alice Haumont, Isadora Lenoël, Peter K. Stys, Samuel David   +6 more
openaire   +2 more sources

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Melatonin ameliorates cuprizone‐induced reduction of hippocampal neurogenesis, brain‐derived neurotrophic factor, and phosphorylation of cyclic AMP response element‐binding protein in the mouse dentate gyrus

Brain and Behavior, 2019
Introduction The aim of this study was to investigate the effects of cuprizone on adult hippocampal neurogenesis in naïve mice. Additionally, we also studied how melatonin affects the neuronal degeneration induced by cuprizone.
Woosuk Kim, Kyu Ri Hahn, Hyo Young Jung, Hyun Jung Kwon, Sung Min Nam, Jong Whi Kim, Joon Ha Park, Dae Young Yoo, Dae Won Kim, Moo‐Ho Won, Yeo Sung Yoon, In Koo Hwang   +11 more
doaj   +1 more source

Progesterone alleviates neural behavioral deficits and demyelination with reduced degeneration of oligodendroglial cells in cuprizone-induced mice. [PDF]

PLoS ONE, 2013
Demyelination occurs widely in neurodegenerative diseases. Progesterone has neuroprotective effects, is known to reduce the clinical scores and the inflammatory response.
Jian-Ning Ye, Xing-Shu Chen, Le Su, Yun-Lai Liu, Qi-Yan Cai, Xiao-Li Zhan, Yan Xu, Shi-Fu Zhao, Zhong-Xiang Yao   +8 more
doaj   +1 more source

Astrocytes: Lessons Learned from the Cuprizone Model

International Journal of Molecular Sciences, 2023
A diverse array of neurological and psychiatric disorders, including multiple sclerosis, Alzheimer’s disease, and schizophrenia, exhibit distinct myelin abnormalities at both the molecular and histological levels. These aberrations are closely linked to dysfunction of oligodendrocytes and alterations in myelin structure, which may be pivotal factors ...
openaire   +2 more sources

Age Influences Microglial Activation After Cuprizone-Induced Demyelination [PDF]

Frontiers in Aging Neuroscience, 2018
Multiple sclerosis (MS) is a chronic inflammatory CNS disease, which causes demyelinated lesions and damages white and gray matter regions. Aging is a significant factor in the progression of MS, and microglia, the immune cells of the CNS tissue, play an important role in all disease stages. During aging, microglia are functionally altered.
Barbara Klein, Barbara Klein, Heike Mrowetz, Heike Mrowetz, Conor Michael Barker, Conor Michael Barker, Simona Lange, Simona Lange, Francisco J. Rivera, Francisco J. Rivera, Francisco J. Rivera, Francisco J. Rivera, Ludwig Aigner, Ludwig Aigner   +13 more
openaire   +3 more sources

Histological correlation of diffusional kurtosis and white matter modeling metrics in cuprizone-induced corpus callosum demyelination [PDF]

, 2014
The cuprizone mouse model is well established for studying the processes of both demyelination and remyelination in the corpus callosum, and it has been utilized together with diffusion tensor imaging (DTI) to investigate myelin and axonal pathology ...
Barazany, Benitez, Blockx, Boretius, Chandran, Cheung, Cheung, Coutu, Falangola, Falangola, Falangola, Falangola, Fieremans, Fieremans, Franco-Pons, Fung, Gao, Grinberg, Grossman, Gómez-Nicola, Harsan, Helpern, Hibbits, Hibbits, Hiremath, Hui, Hui, Innocenti, Jacque, Jensen, Jensen, Jensen, Jones, Kipp, Leergaard, Lu, Mason, Matsushima, Olivares, Page, Paxinos, Raab, Rasband, Remington, Reyes-Haro, Sargon, Schmidt, Skripuletz, Song, Stidworthy, Sun, Switzer, Tabesh, Thiessen, Torkildsen, Van Cauter, Vanhoutte, Veraart, Wang, Wu, Xie, Yang, Yang, Zhang, Zhuo   +64 more
core   +1 more source

GAS6 Enhances Repair Following Cuprizone-Induced Demyelination

PLoS ONE, 2010
Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of cell types, including cells of the central nervous system (CNS). In this study, we tested the hypothesis that administration of recombinant human Gas6 (rhGas6) protein ...
Vladislav Tsiperson, Xiaosong Li, Gary J Schwartz, Cedric S Raine, Bridget Shafit-Zagardo   +4 more
openaire   +4 more sources

The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice [PDF]

, 2017
Background There is a large body of experimental evidence suggesting that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are capable of modulating immune function.
Paul, Friedemann, Rothe, Michael, Siegert, Elise, Weylandt, Karsten H.   +3 more
core   +4 more sources