Cuprizone feed formulation influences the extent of demyelinating disease pathology
Scientific Reports, 2021 Cuprizone is a copper-chelating agent that induces pathology similar to that within some multiple sclerosis (MS) lesions. The reliability and reproducibility of cuprizone for inducing demyelinating disease pathology depends on the animals ingesting ...
Lillian M. Toomey +9 more
doaj +1 more source
Table_1_Visual Evoked Potentials to Monitor Myelin Cuprizone-Induced Functional Changes.DOCX [PDF]
, 2022 The visual system is one of the most accessible routes to study the central nervous system under pathological conditions, such as in multiple sclerosis (MS).
Su-Chun Huang (11833853) +7 more
core +1 more source
NeuroImage, 2022 Disruptions in oxidative metabolism may occur in multiple sclerosis and other demyelinating neurological diseases. The impact of demyelination on metabolic rate is also not understood.
Mada Hashem +4 more
doaj +1 more source
Effects of calcitriol and fingolimod on remyelination in the cuprizone model [PDF]
, 2020 Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, and neurodegeneration of the central nervous system (CNS). There is no cure. Current treatments target the autoimmune aspects of MS but do not directly improve CNS
Nystad, Agnes Elisabeth
core +1 more source
Myelin copper and the cuprizone model of schizophrenia [PDF]
Frontiers in Bioscience, 2011 In recent years increasing evidence is pointing toward white matter abnormalities in schizophrenia and other psychiatric disorders. The present paper will provide an overview over the role of myelin in cognition and brain function, and its potential involvement in brain disorders.
Nicole R, Herring, Christine, Konradi
openaire +2 more sources
Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis.
Iraj Ragerdi Kashani +7 more
doaj +1 more source
Visual Evoked Potentials to Monitor Myelin Cuprizone-Induced Functional Changes
Frontiers in Neuroscience, 2022 The visual system is one of the most accessible routes to study the central nervous system under pathological conditions, such as in multiple sclerosis (MS).
Silvia Marenna +10 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are ...
Ana Caroline Brambilla Falvella +12 more
doaj +1 more source
Localized Increased Permeability of Blood–Brain Barrier for Antibody Conjugates in the Cuprizone Model of Demyelination [PDF]
, 2023 The development of new neurotherapeutics depends on appropriate animal models being chosen in preclinical studies. The cuprizone model is an effective tool for studying demyelination and remyelination processes in the brain, but blood–brain barrier
Vladimir Chekhonin +10 more
core +1 more source
Cuprizone in Peanut Butter: An Alternative Method of Cuprizone Administration to Model Demyelination of the Central Nervous System. [PDF]
J Am Assoc Lab Anim SciModeling disease in rodents is essential for preclinical research, particularly in the development of drugs and therapies. Traditional disease modeling approaches often rely on invasive and stressful procedures such as repeated injections and/or surgical approaches.
Hawker B +4 more
europepmc +3 more sources