Growth Differentiation Factor 11 Is a Circulating Regulator of Oligodendrocyte Differentiation and CNS Myelin Formation and Repair. [PDF]
CNS Neurosci TherSystemically administered GDF11 enhances CNS myelin formation and repair across both developmental and disease contexts. GDF11 promotes the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes, increases myelin sheath thickness in neonatal mice, and accelerates remyelination in both the cuprizone‐induced demyelination model ...
Zhang Z +5 more
europepmc +2 more sources
Myelin copper and the cuprizone model of schizophrenia [PDF]
Frontiers in Bioscience, 2011 In recent years increasing evidence is pointing toward white matter abnormalities in schizophrenia and other psychiatric disorders. The present paper will provide an overview over the role of myelin in cognition and brain function, and its potential involvement in brain disorders.
Nicole R, Herring, Christine, Konradi
openaire +2 more sources
Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis.
Iraj Ragerdi Kashani +7 more
doaj +1 more source
Effects of calcitriol and fingolimod on remyelination in the cuprizone model [PDF]
, 2020 Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, and neurodegeneration of the central nervous system (CNS). There is no cure. Current treatments target the autoimmune aspects of MS but do not directly improve CNS
Nystad, Agnes Elisabeth
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Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry. [PDF]
Angew Chem Int Ed EnglLiquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Zhang C +7 more
europepmc +2 more sources
Visual Evoked Potentials to Monitor Myelin Cuprizone-Induced Functional Changes
Frontiers in Neuroscience, 2022 The visual system is one of the most accessible routes to study the central nervous system under pathological conditions, such as in multiple sclerosis (MS).
Silvia Marenna +10 more
doaj +1 more source
Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression. [PDF]
Arch Pharm (Weinheim)Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Rychlik N +4 more
europepmc +2 more sources
Table_1_Visual Evoked Potentials to Monitor Myelin Cuprizone-Induced Functional Changes.DOCX
, 2022 The visual system is one of the most accessible routes to study the central nervous system under pathological conditions, such as in multiple sclerosis (MS).
Su-Chun Huang (11833853) +7 more
core +1 more source
Brain and Behavior, 2019 Introduction The aim of this study was to investigate the effects of cuprizone on adult hippocampal neurogenesis in naïve mice. Additionally, we also studied how melatonin affects the neuronal degeneration induced by cuprizone.
Woosuk Kim +11 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are ...
Ana Caroline Brambilla Falvella +12 more
doaj +1 more source