Results 51 to 60 of about 6,444 (163)
Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity
The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert +2 more
wiley +1 more source
Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are ...
José A. Crippa (3153048) +9 more
core +1 more source
Astrocytic EAAT‐2 Upregulation Supports Neuro‐Axonal Homeostasis in Chronic Inflammatory CNS Lesions
Inflammatory CNS lesions increase extracellular glutamate. Astrocytic EAAT regulation controls glutamate clearance, stabilizes axonal Ca2+ homeostasis, and determines neurite survival during chronic neuroinflammation. ABSTRACT Neuronal loss in multiple sclerosis (MS) is a key factor in the progression of disability.
Luise Reukauf +9 more
wiley +1 more source
De- and remyelination of the corpus callosum and cortex during cuprizone feeding and TnP treatment. (A) C57BL/6 male mice (cuprizone mice were maintained on a normal diet for the duration of 6 weeks under treatment or not with TnP) were scored (0–5 ...
Tais Aparecida Matozo Souza (3778510) +4 more
core +1 more source
Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are ...
José A. Crippa (3153048) +9 more
core +1 more source
The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada +15 more
wiley +1 more source
In toxic demyelination oligodendroglial cell death occurs early and is FAS independent
Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS). The underlying mechanisms are largely unknown.
Amke Hesse +7 more
doaj +1 more source
Deep gray matter demyelination detected by magnetization transfer ratio in the cuprizone model. [PDF]
In multiple sclerosis (MS), the correlation between lesion load on conventional magnetic resonance imaging (MRI) and clinical disability is weak. This clinico-radiological paradox might partly be due to the low sensitivity of conventional MRI to detect ...
Sveinung Fjær +6 more
doaj +1 more source
Macroscopic changes of the thymi upon cuprizone treatment.
Four week-old male mice were treated with cuprizone for one week. Representative photographs (A) of the open chest of a control (Cont.) and a cuprizone-treated (CPZ) animal are demonstrated. Arrows point to the thymi of the mice.
Peter Acs (751324) +10 more
core +1 more source
Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are ...
José A. Crippa (3153048) +9 more
core +1 more source

