Results 51 to 60 of about 5,891 (192)
Imaging Cuprizone-Induced Mitochondrial Dysfunction [PDF]
, 2020 Abstract Cuprizone is a copper chelator that induces mitochondrial dysfunction in myelin-producing oligodendrocytes and hepatic cells. Inhibition of oxidative phosphorylation has been proposed as a potential mechanism, but the exact relationship between shape changes and metabolic alterations is not well-understood.
Lucille A. Ray +4 more
openaire +1 more source
Macroscopic changes of the thymi upon cuprizone treatment. [PDF]
, 2015 Four week-old male mice were treated with cuprizone for one week. Representative photographs (A) of the open chest of a control (Cont.) and a cuprizone-treated (CPZ) animal are demonstrated. Arrows point to the thymi of the mice.
Peter Acs (751324) +10 more
core +1 more source
Image_3_Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13.tif [PDF]
, 2021 Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are ...
José A. Crippa (3153048) +9 more
core +1 more source
Neurobiology of Disease, 2013 A growing body of evidence suggests the involvement of inflammatory processes in the pathophysiology of schizophrenia. Four- to 8-week exposure to cuprizone, a copper chelator, causes robust demyelination and has been used to build a model for multiple ...
Tomoaki Tezuka +12 more
doaj +1 more source
Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development
Environmental Toxicology, EarlyView.ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo +10 more
wiley +1 more source
Clozapine enhanced recovery after cessation of cuprizone administration. [PDF]
, 2019 (a) Experimental design for investigating remyelination events. Mice were fed a diet containing 0.3% cuprizone for 6 weeks. After the 5th week of cuprizone, clozapine or vehicle treatment began.
Bronwen Connor (614009) +4 more
core +1 more source
High‐Resolution Diffusion Kurtosis Imaging of Hippocampus Subfields Across the Healthy Lifespan
NMR in Biomedicine, Volume 39, Issue 8, August 2026.Developmental and aging changes were examined in the hippocampus using 1 mm isotropic diffusion kurtosis imaging in 363 participants aged 5–90 years. HippUnfold enabled automated subfield segmentation and unfolded hippocampal maps. Whole‐hippocampus showed distinct lifespan trajectories: volume, quadratic; MD, negative Gamma Variate; FA, positive Gamma
Pablo Stack‐Sanchez +3 more
wiley +1 more source
Diagnostics, 2020 This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo 7 T proton magnetic resonance spectroscopy.
Do-Wan Lee +7 more
doaj +1 more source
Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model. [PDF]
PLoS ONE, 2016 Cuprizone administration in mice provides a reproducible model of demyelination and spontaneous remyelination, and has been useful in understanding important aspects of human disease, including multiple sclerosis.
Ian Tagge +9 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.ABSTRACT The conceptual landscape of cell death has evolved beyond the traditional dichotomy of apoptosis and necrosis to encompass diverse regulated pathways including necroptosis, autophagy, ferroptosis, and pyroptosis. Necroptosis, a caspase‐independent inflammatory form of programmed cell death, has emerged as a critical driver of the pathogenesis ...
Fengxin Wang +9 more
wiley +1 more source