Results 71 to 80 of about 8,969 (212)

Dietary vitamin D3 supplements reduce demyelination in the cuprizone model. [PDF]

PLoS ONE, 2011
Vitamin D is emerging as a probably important environmental risk factor in multiple sclerosis, affecting both susceptibility and disease progression. It is not known to what extent this effect is due to a modulation of peripheral lymphocyte function, or ...
Stig Wergeland, Øivind Torkildsen, Kjell-Morten Myhr, Lage Aksnes, Sverre Jarl Mørk, Lars Bø   +5 more
doaj   +1 more source

A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis [PDF]

, 2019
Background: Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin ...
Barbierato, M., Contarini, G., Facci, L., Franceschini, D., Giusti, P., Zusso, M.   +5 more
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Neuronal Activity Promotes Node‐Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System

Glia, Volume 74, Issue 4, April 2026.
Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano, Clément Perrot, Elisa Mazuir, Melina Thetiot, Marie‐Stéphane Aigrot, Paul Stheneur, François‐Xavier Lejeune, Bruno Stankoff, Catherine Lubetzki, Nathalie Sol‐Foulon, Anne Desmazières   +10 more
wiley   +1 more source

Dietary Supplementation With Acer truncatum Oil Promotes Remyelination in a Mouse Model of Multiple Sclerosis

Frontiers in Neuroscience, 2022
BackgroundMultiple sclerosis is a chronic demyelinating disease of uncertain etiology. Traditional treatment methods produce more adverse effects. Epidemiological and clinical treatment findings showed that unknown environmental factors contribute to the
Yuhuan Xue, Xiaoyan Zhu, Wenyong Yan, Zhihan Zhang, Enhui Cui, Yongji Wu, Cixia Li, Jiarong Pan, Qijiang Yan, Xuejun Chai, Shanting Zhao   +10 more
doaj   +1 more source

Five decades of cuprizone, an updated model to replicate demyelinating diseases [PDF]

, 2017
: Introduction: Demyelinating diseases of the central nervous system (CNS) comprise a group of neurological disorders characterized by progressive (and eventually irreversible) loss of oligodendrocytes and myelin sheaths in the white matter tracts.
GONZALEZ PEREZ, OSCAR, GONZALEZ PEREZ, OSCAR, MENDEZ VICTORIANO, GERARDO, MENDEZ VICTORIANO, GERARDO, MORALES LUCKIE, RAUL ALBERTO, MORALES LUCKIE, RAUL ALBERTO, VEGA RIQUER, JOSE MANUEL, VEGA RIQUER, JOSE MANUEL   +7 more
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White matter integrity as a predictor of response to treatment in first episode psychosis [PDF]

, 2013
The integrity of brain white matter connections is central to a patient's ability to respond to pharmacological interventions. This study tested this hypothesis using a specific measure of white matter integrity, and examining its relationship to ...
Bonaccorso, S, Chaddock, C, David, AS, Dazzan, P, Dell'acqua, F, Diforti, M, Handley, R, Kapur, S, Mondelli, V, Murray, RM, Pariante, CM, Reinders, AA, Reis Marques, T, Simmons, A, Taylor, H   +14 more
core   +2 more sources

Functional Training Mitigates Reduced Circulating Indole‐3‐Lactate Levels in Persons With Relapsing–Remitting Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Indoles are tryptophan (Trp)‐derived metabolites that are produced by the gut microbiota and may influence the gut‐microbiota‐brain axis in multiple sclerosis (MS). Indole‐3‐lactate (ILA) is reduced in persons with MS and improves MS clinical scores in animal models via its anti‐inflammatory remyelinating properties.
Tiffany Wences Chirino, Frederike Adammek, Sergen Belen, Matteo Winker, Sebastian Proschinger, Annette Rademacher, Marit L. Schlagheck, Alexander Schenk, Marie Kupjetz, David Walzik, Clemens Warnke, Marcel Reuter, Friederike Rosenberger, Tim Meyer, Adrian McCann, Per Magne Ueland, Niklas Joisten, Philipp Zimmer   +17 more
wiley   +1 more source

Nicotinamide Adenine Dinucleotide Supplementation Improves Cuprizone‐Induced Multiple Sclerosis‐Related Behavioral Changes in C57BL/6J Mice

Brain and Behavior
Objective To investigate whether nicotinamide adenine dinucleotide (NAD+) supplementation can improve behavioral changes in a cuprizone‐intoxicated mouse model.
Shuang Song, Ruoyi Guo, Jiangyuan Guo, Bin Li, Yusen Han, Huining Zhang, Li Guo   +6 more
doaj   +1 more source

17β-Estradiol Enhances the Efficacy of Adipose-Derived Mesenchymal Stem Cells on Remyelination in Mouse Model of Multiple Sclerosis [PDF]

Acta Medica Iranica, 2012
Previous studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (MSCs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (MS).
Iraj Ragerdi Kashani, Azim Hedayatpour, Parichehr Pasbakhsh, Leya Kafami, Nader Atlasi, Vahid Pirhajati Mahabadi, Reza Mamoudi, Maryam Baazm   +7 more
doaj   +1 more source

Effects of insulin-like growth factor 1 on pathologic process in the cuprizone model of multiple sclerosis [PDF]

, 2017
The study aimed to evaluate the effect of insulin-like growth factor 1 (IGF-1) on the cuprizone-induced murine model of demyelination and accompanying astrogliosis. Demyelination was induced in 14 adult male mice by 0.3% cuprizone in drinking water. Five
Федоришин, Д. А.
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