Results 71 to 80 of about 6,317 (193)

APP/Aβ Signaling Orchestrates Reactive Astrocyte Networks in Alzheimer's Disease

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Stress increases astrocyte APP production, generating amyloid‐β (Aβ). Aβ then diffuses to neighboring astrocytes, stimulating further APP and Aβ production and creating a self‐reinforcing cycle. Over time, impaired Aβ clearance leads to its accumulation, chronic inflammation, and contributes to sporadic Alzheimer's disease. ABSTRACT Alzheimer's disease
Gretsen Velezmoro Jauregui, Sophie Coomes, Elizabeth Emmett, Alex Thatcher, Nicole Oyelakin, Maria Čarna, Jana Zelinkova, Jan Sebastian Novotny, Natalie Polakova, Tarun Kuruvilla, Robert Zorec, Alexei Verkhratsky, Vladimir Parpura, David Morgan, Kenneth L. Moya, Clara Limback‐Stokin, Gorazd Bernard Stokin   +16 more
wiley   +1 more source

Effect of cuprizone on thymic epithelial cells.

, 2015
Four week-old male mice were treated with cuprizone for one week, then immune-staining (A) with FITC-labelled anti-EpCAM1 (green) and PE-labelled anti-Ly-51 (red) antibodies was performed on thymic sections of untreated (Control) and cuprizone-treated ...
Peter Acs (751324), Gergely Talaber (505572), Krisztian Kvell (364768), Zsolt Illes (441094), Arpad Szanto (751327), Katalin Fekete (751326), Petra Zalan (617403), Zita Bognar (751328), Sara Veto (751323), Ferenc Gallyas Jr. (751325), Izabella Solti (751322)   +10 more
core   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, Volume 111, Issue 7, Page 3179-3190, 1 July 2026.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Titration of cuprizone induces reliable demyelination

Brain Research
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Cuprizone-induced demyelination, wherein mice are fed a diet containing the copper chelator cuprizone, is a well-established model that replicates key features of demyelination and remyelination. However, the dose-response relationship of cuprizone is complex; high
Nicole, Wigger, Johann, Krüger, Elise, Vankriekelsvenne, Markus, Kipp   +3 more
openaire   +2 more sources

Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination

ASN Neuro, 2012
In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination.
Norah Hibbits, Jun Yoshino, Tuan Q. Le, Regina C. Armstrong   +3 more
doaj   +1 more source

The neuro‐immune interface in multiple sclerosis: From pathogenesis to therapeutic opportunities

Brain‐X, Volume 4, Issue 2, June 2026.
This review analyzes the immunopathology of multiple sclerosis (MS), focusing on the interactions between innate and adaptive immunity, glial cells, and key molecular mechanisms such as MHC, chemokines, cytokines, and the complement system. It also explores current and emerging therapeutic strategies, providing a comprehensive view of disease ...
Ruohan Wang, Mengqi Li, Xinyao Chen, Manling Lang, Qifei Cong   +4 more
wiley   +1 more source

Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model

Cells, 2020
To unravel the failure of remyelination in multiple sclerosis (MS) and to test promising remyelinating treatments, suitable animal models like the well-established cuprizone model are required. However, this model is only standardized in young mice. This
Stefan Gingele, Florian Henkel, Sandra Heckers, Thiemo M. Moellenkamp, Martin W. Hümmert, Thomas Skripuletz, Martin Stangel, Viktoria Gudi   +7 more
doaj   +1 more source

Characterisation of cuprizone-induced cell death.

, 2015
Four week-old male mice were treated with cuprizone for one week. Type of cell death was determined using flow cytometry following double staining with FITC-labelled AnnexinV and propidium iodide thymus suspensions of untreated (Control, grey bars) and ...
Peter Acs (751324), Gergely Talaber (505572), Krisztian Kvell (364768), Zsolt Illes (441094), Arpad Szanto (751327), Katalin Fekete (751326), Petra Zalan (617403), Zita Bognar (751328), Sara Veto (751323), Ferenc Gallyas Jr. (751325), Izabella Solti (751322)   +10 more
core   +1 more source

Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice [PDF]

, 1998
To study microglial/macrophage infiltration, a cuprizone-induced model for demyelination in C57BL/6 mice was established. Cuprizone is known to cause demyelination in Swiss mice, however, cuprizone-induced demyelination in C57BL/6 mice has not been ...
Knapp, G.W., Ting, J.P.-Y., Suzuki, K., Hiremath, M.M., Saito, Y., Matsushima, G.K.   +5 more
core   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source