Results 91 to 100 of about 8,969 (212)

Targeted Delivery of Microneurotrophin BNN27 via Biomaterial Grafts Protects Retinal Ganglion Cells After Optic Nerve Injury

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 1, January 2026.
ABSTRACT Emerging neurotrophin treatments for optic nerve injury (ONI) aim to prevent the loss of retinal ganglion cells (RGCs) and enhance axonal regeneration. Microneurotrophins (MNTs), small‐molecule mimetics of neurotrophins, have shown neuroprotective effects in various animal models of neurodegeneration, yet MNT effects on ONI remain unknown ...
K. Georgelou, E. A. Saridaki, C. P. Apostolidou, X. Mallios, A. Papagiannaki, K. Karali, T. Katsila, T. Calogeropoulou, A. Mitraki, D. Karagogeos, I. Charalampopoulos, A. Gravanis, M. Savvaki, D. S. Tzeranis   +13 more
wiley   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Pathologic and Protective Roles for Microglial Subsets and Bone Marrow- and Blood-Derived Myeloid Cells in Central Nervous System Inflammation [PDF]

, 2015
Inflammation is a series of processes designed for eventual clearance of pathogens and repair of damaged tissue. In the context of autoimmune recognition inflammatory processes are usually considered to be pathological. This is also true for inflammatory
Agathe eJasson, Agathe eJasson, Agnieszka eWlodarczyk, Jyothi eThyagabhavan Mony, Kirstine Nolling Jensen, Oriane eCédile, Reza eKhorooshi, Trevor eOwens   +7 more
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From Demyelination to Intervention: Natural Compounds as Emerging Therapeutic Targets in Multiple Sclerosis Neuroinflammation

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Multiple sclerosis (MS) is a chronic immune‐mediated inflammatory demyelinating disease of the central nervous system (CNS), characterized by multifocal lesions, axonal damage, and progressive neurological dysfunction, imposing a heavy burden on patients and healthcare systems.
Zhiyong Long, Qianyue Yang, Yonghe Wu, Lifei Wan, Liuting Zeng, Lingyun Sun, Poorani Gurumallesh   +6 more
wiley   +1 more source

Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination

ASN Neuro, 2012
In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination.
Norah Hibbits, Jun Yoshino, Tuan Q. Le, Regina C. Armstrong   +3 more
doaj   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, Volume 1, Issue 2, Page 104-120, December 2025.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]

, 2017
α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles, Cararo-Lopes, Marina Minto, Kawamoto, Elisa Mitiko, Mazucanti, Caio Henrique Yokoyama, Scavone, Cristoforo   +4 more
core   +1 more source

Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets

Brain and Behavior, Volume 15, Issue 11, November 2025.
The glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) liraglutide alleviates disease severity of experimental autoimmune encephalomyelitis (EAE) mice by reducing splenic T helper 1 cell expansion. These findings suggest GLP‐1RA might exert disease‐modifying effects in the EAE model through peripheral immunomodulatory effects of splenic T helper cells.
Shuang Song, Bin Li, Ruoyi Guo, Yi Zhou, Yumei Xue, Li Guo   +5 more
wiley   +1 more source

Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component. [PDF]

, 2018
Neurodegenerative diseases represent great challenges for basic science and clinical medicine because of their prevalence, pathologies, lack of mechanism-based treatments, and impacts on individuals.
A Bellucci, A Bonito-Oliva, A Boroujerdi, A Brockington, A Burgess, A Dorr, A Lockhart, A Manook, A Parievsky, A Rahman, A Rönnbäck, A Snellman, A Vercelli, AB Muñoz-Manchado, AD Kane, Adelaide Greco, AF Martins, AF Mellin, AG Barbeito, AH Jacobs, AI Brooks, AJ Lin, AK Srivastava, AL Brownell, AL Southwell, AM Hall, AP Patterson, AR Varma, AY Lai, B Joglar, B Oosthuyse, B Ott, B Platt, B Schwendele, B Stankoff, B Vastenhouw, BJ Turner, BS Buddeberg, C Bigot, C Casteels, C Cauwenberghe Van, C Cepeda, C Klein, C Procaccini, C Romberg, CA Denny, CA Hawkes, CE Moussa, CG Radu, CI Choi, CJ Macmillan, CY Lin, D Alvarez-Fischer, D Dam Van, D Diorio, D Hare, D Havas, D Liebetanz, D Litteljohn, D McLean, D Paula Faria de, D Rial, DA Shear, DM Iascone, DP McCarthy, DW Luchtman, DW Zang, DW Zang, E Milner, E Rockenstein, E Storkebaum, EK Agyare, EL Oleszak, EM Knight, EM Robbins, F Blandini, F Gilli, F Hébert, F Kara, F Luo, F Luo, F Mattner, FS Roman, G Andringa, G Kreiner, G Poisnel, G Rougon, GD Vickle Van, GE Meredith, GE Woloschak, GF Passos, GL Bowman, H Benveniste, H Brautigam, H Gu, H Li, H Oakley, H Schmalbruch, H Xiong, HB Fernandes, HG Niessen, HJ Newbery, HJ Waldvogel, HK Li-Chun, HV Vinters, HY Hsiao, I Dewachter, I Peruga, I Rattray, IG Kirkinezos, IR Macdonald, J Apelt, J Beauquis, J Boix, J Dorpe Van, J Drouin-Ouellet, J Grandjean, J Hua, J Klohs, J Klohs, J Lengfeld, J Luo, J Mahler, J Pépin, J Zhang, JA Helpern, JC Furtado, JC Glorioso, JD Lee, JE Hanson, JF Poduslo, JF Reilly, JJ Steventon, JK Ryu, JL Berard, JL Jankowsky, JL Lynch, JM Moser, JM Raamsdonk Van, JM Redwine, JP Lerch, JS Lunn, JS Toomey, K Miyazaki, K Miyazaki, K Poesen, KA Jellinger, KJ Bryan, KK Cheng, KK Kandimalla, KL Berggren, KM Jaruszewski, KR Rekha, KR Stover, KS Lindenberg, KS Lowry, KS Montgomery, L Auletta, L Chen, L Giménez-Llort, L Holcomb, L Mao, L Mucke, LA Thomason, LB Tovar-y-Romo, LH Wang, LI Bruijn, LM Gorton, Luigi Auletta, M Aggarwal, M Azzouz, M Baranyi, M Honer, M Knobloch, M Mancini, M Terzioglu, M Tóth, M Ziebell, M-J Lee, MA Busche, MA Hickey, Marcello Mancini, MC Evans, MD Meadowcroft, MD Santin, ML James, ML Starkey, MM Khalil, MM Paz Soldán, MY Heng, N Beckmann, N Nathoo, N Nathoo, NG Spencer, NM Lewandowski, O Philipson, OP Keifer Jr., P Bagga, P Bose, P Dibaj, P Kennel, P Zamboni, PM Switonski, PN Lacor, PO Fernagut, PO Fernagut, PO Fernagut, R Berg Van den, R Betarbet, R Chamberlain, R Chang, R Günther, R Muramatsu, R Zhang, RA Grant, RL Faull, RM Deacon, RM Nicholson, S Acharjee, S Fjær, S Franciosi, S Gargiulo, S George, S Kikuta, S Knippenberg, S Knippenberg, S Kumar-Singh, S Kumar-Singh, S Nessler, S Oddo, S Oddo, S Oliván, S Onida, S Ramaswamy, S Rojas, S Sarkar, S Serres, S Venneti, Sandra Albanese, SD Girard, SJ Sawiak, SJ Teipel, SJ Webster, SK Sharma, SM Fleming, SM Fleming, SR Suwijn, T Arora, T Spires-Jones, T Yamasaki, T Yasuhara, TN Luong, TN Taylor, TN Taylor, TO Abakumova, V Bogaerts, VL Eaton, W Atkinson, W Lin, W Lu, W Xu, WA Roscoe, WL Klein, WT Lee, X Wang, Y Cheng, Y Kishimoto, Y Li, Y Liu, Y Waerzeggers, Y Wei, Y Zhao, Y Zhou, YZ Wadghiri, YZ Wadghiri, Z Zhong   +275 more
core   +1 more source