Mediators of Inflammation, 2013 We recently demonstrated that sildenafil reduces the expression of cytokines, COX-2, and GFAP in a demyelinating model induced in wild-type (WT) mice.
Catarina Raposo +5 more
doaj +1 more source
A Histological Study of the Impact of Bone Marrow Mesenchymal Stem Cells- Derived Exosomes on the Corpus Callosum in a Cuprizone-Induced Mouse Model of Multiple Sclerosis [PDF]
The Egyptian Journal of HistologyIntroduction: A chronic demyelinating disease that affects millions of peoples worldwide is multiple sclerosis (MS). There are currently no remyelination therapy for this disease, and exosomes are being explored as an alternative.Aim of the Work: To ...
Bosy Hassan +3 more
doaj +1 more source
Wirkungen von rekombinantem humanen Erythropoietin im Cuprizone-Maus-Modell [PDF]
, 2012 Neuroprotektive und neuroregenerative Eigenschaften von Erythropoietin (EPO) wurden u.a. in Modellen der experimentellen autoimmunen Enzephalomyelitis (etablierte Tiermodelle zur Untersuchung der Multiplen Sklerose (MS)) und in Patienten mit chronisch ...
Hagemeyer, Nora
core +1 more source
Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra. [PDF]
, 2015 Conventional MRI is frequently used during the diagnosis of multiple sclerosis but provides only little additional pathological information. Proton MRS (1H-MRS), however, provides biochemical information on the lesion pathology by visualization of a ...
Santermans, Eva +12 more
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Folia Neuropathologica, 2017 The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system.
Mohammadreza Semnani +3 more
doaj +1 more source
TnP increments the remyelination and inhibits the influx of leukocytes in corpus callosum in cuprizone model. [PDF]
, 2017 De- and remyelination of the corpus callosum and cortex during cuprizone feeding and TnP treatment. (A) C57BL/6 male mice (cuprizone mice were maintained on a normal diet for the duration of 6 weeks under treatment or not with TnP) were scored (0–5 ...
Tais Aparecida Matozo Souza (3778510) +4 more
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Diffusional kurtosis detects cortical demyelination in the cuprizone mouse model [PDF]
, 2012 The cuprizone mouse model is a well characterized animal model of demyelination. Recently, cortical demyelination has also been observed. Diffusion tensor imaging (DTI) studies have demonstrated the pathology of the corpus callosum (CC) in cuprizone ...
LaFrancois, J +9 more
core
Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats [PDF]
, 2018 Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum.Methods: Twenty adult ...
Ameen, M.O. +8 more
core +2 more sources
Frontiers in Pharmacology, 2019 Growing evidence has implicated that myelin deficits and neuroinflammation are the coexisted pathological features that contribute to the mood swing and cognitive decline in major depressive disorder (MDD) and multiple sclerosis (MS).
Yanbo Zhang +8 more
doaj +1 more source
Protective effects of cannabidiol on cuprizone-induced demyelination in C57BL/6 mice
Journal of Contemporary Medical Sciences, 2017 Objective Experimental and clinical studies suggest that oxidative stress plays an important role in the pathogenesis of multiple sclerosis. In this study, we have investigated the effects of the non-psychoactive cannabinoid cannabidiol (CBD), which ...
Maryam Sajjadian +8 more
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