Results 111 to 120 of about 8,969 (212)

Antiaris africana aqueous extract inhibits chronic demyelination and seizures in mice

Heliyon
Demyelinating diseases are commonly associated with epileptic seizures and have limited management options. Hence, the need to investigate potential options for management of such seizures.
Ransford Amoah, John Danquah, Priscilla Kolibea Mante   +2 more
doaj   +1 more source

Mild burn amplifies the locomotive depression in demyelinated mice without muscle pathophysiological changes.

PLoS ONE
IntroductionPatients with mild burns take most accounts, however, the impact of mild burns is less known. Nerve destruction leads to muscle atrophy. We posit that even mild burn injury could worsen demyelinated nerves related to muscle pathophysiological
Juquan Song, Amina Ei Ayadi, Victoria G Rontoyanni, Steven E Wolf   +3 more
doaj   +1 more source

Cuprizone intoxication perturbs central nervous system metabolism

, 2016
Cuprizone intoxication is a common animal model used to test new myelin regenerative therapies for diseases such as multiple sclerosis. Mice fed this copper chelator develop reversible, region-specific oligodendrocyte loss and demyelination.  While the cellular correlates influencing myelin have been well studied in this model, there
Taraboletti, Alexandra, Huang, He, Shriver, Leah   +2 more
openaire   +1 more source

3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice

Frontiers in Neuroimaging
PurposeTo test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model.MethodsNon-aqueous myelin protons have ultrashort T2s and are “invisible” with conventional
Adam C. Searleman, Yajun Ma, Srihari Sampath, Srinath Sampath, Robert Bussell, Eric Y. Chang, Eric Y. Chang, Lisa Deaton, Andrew M. Schumacher, Jiang Du, Jiang Du, Jiang Du   +11 more
doaj   +1 more source

Evaluation of the cuprizone model [PDF]

, 2022
openaire   +1 more source

Cuprizone demyelination induces a unique inflammatory response in the subventricular zone [PDF]

, 2016

core   +1 more source

Pilot functional magnetic resonance imaging study of clemastine‐aided functional recovery on a mouse model of demyelination

Neuroprotection
Background Multiple sclerosis (MS) is a chronic demyelinating disease characterized by autoimmune attacks on myelin sheaths. Its deleterious effects may be reversed by remyelination, a process that restores the integrity of myelin sheaths and ...
Ander Egimendia, Irati L. de laPisa, Daniel Padro, Lorena Colás, Sandra Plaza‐García, David Otaegui, Pedro Ramos‐Cabrer   +6 more
doaj   +1 more source

Ferroptosis: copper-iron connection in cuprizone-induced demyelination

Neural Regeneration Research, 2022
Priya Jhelum, Samuel David
openaire   +3 more sources

Effects of Green Tea Epigallocatechin-3-Gallate (EGCG) On Proteolipid Protein (PLP) and Oligodendrocyte Transcription Factor 1 (Olig1) Expression in the Cerebral Cortex of Cuprizone Induced Multiple Sclerosis Mice; A Western Blot Study

Caspian Journal of Neurological Sciences, 2016
Background: The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system.
Mohammad-Reza Semnani, Farhad Mashayekhi, Mahnaz Azarnia, Zivar Salehi   +3 more
doaj  

Loss of oligodendrocyte transcription factor 2 protein expression in metabolically stressed oligodendrocytes. [PDF]

Acta Neuropathol
Kaddatz H, Wenzel L, Pril E, Meien S, Harz V, Burkert L, Behrangi N, Zimmermann A, Frintrop L, Amor S, Kipp M, Heinig L.   +11 more
europepmc   +1 more source