Results 101 to 110 of about 5,891 (192)

Antiaris africana aqueous extract inhibits chronic demyelination and seizures in mice

Heliyon
Demyelinating diseases are commonly associated with epileptic seizures and have limited management options. Hence, the need to investigate potential options for management of such seizures.
Ransford Amoah, John Danquah, Priscilla Kolibea Mante   +2 more
doaj   +1 more source

Effect of Fasudil on remyelination following cuprizone-induced demyelination.

CNS neuroscience & therapeutics, 2019
Multiple sclerosis is characterized by demyelination/remyelination, neuroinflammation, and neurodegeneration. Cuprizone (CPZ)-induced toxic demyelination is an experimental animal model commonly used to study demyelination and remyelination in the central nervous system.
Wang, Jing, Sui, Ruo‐Xuan, Miao, Qiang, Wang, Qing, Song, Li‐Juan, Yu, Jie‐Zhong, Li, Yan‐Hua, Xiao, Bao‐Guo, Ma, Cun‐Gen   +8 more
openaire   +2 more sources

Mild burn amplifies the locomotive depression in demyelinated mice without muscle pathophysiological changes.

PLoS ONE
IntroductionPatients with mild burns take most accounts, however, the impact of mild burns is less known. Nerve destruction leads to muscle atrophy. We posit that even mild burn injury could worsen demyelinated nerves related to muscle pathophysiological
Juquan Song, Amina Ei Ayadi, Victoria G Rontoyanni, Steven E Wolf   +3 more
doaj   +1 more source

Melatonin ameliorates astrogliosis and microgliosis in a cuprizone demyelinating mouse model

Biochemistry and Biophysics Reports
Background and purpose: Several investigations have reported that melatonin is involved in the amelioration of the inflammatory process, improvement of myelin function, and regeneration in the central nervous system (CNS).
Mehdi Alidadi, Negar Omidi, Mahdad Abdi, Maryam Mohammadi, Maryam Shabani, Iraj Ragerdi Kashani   +5 more
doaj   +1 more source

3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice

Frontiers in Neuroimaging
PurposeTo test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model.MethodsNon-aqueous myelin protons have ultrashort T2s and are “invisible” with conventional
Adam C. Searleman, Yajun Ma, Srihari Sampath, Srinath Sampath, Robert Bussell, Eric Y. Chang, Eric Y. Chang, Lisa Deaton, Andrew M. Schumacher, Jiang Du, Jiang Du, Jiang Du   +11 more
doaj   +1 more source

The sphingosine-1-phosphate receptor 1 modulator ponesimod repairs cuprizone-induced demyelination and induces oligodendrocyte differentiation [PDF]

Sphingosine-1-phosphate receptor (S1PR) modulators are clinically used to treat relapse-remitting multiple sclerosis (MS) and the early phase of progressive MS when inflammation still prevails.
Schepers, Melissa, Ait-Tihyaty, Maria, Willems, Emily, Wolfs, Esther, Hellings, Niels, Piccart, Elisabeth, VANMIERLO, Tim, Vanmierlo, Tim; id_orcid   +7 more
core   +1 more source

Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice. [PDF]

Demyelination within the central nervous system (CNS) is a significant feature of debilitating neurological diseases such as multiple sclerosis and administering the copper-selective chelatorcuprizone to mice is widely used to model demyelination in vivo.
Wang, Y, Crouch, PJ, Donnelly, PS, White, AR, Buncic, G, Mercer, SW, Kilpatrick, TJ, Kysenius, K, Liddell, JR, Murray, SS, Hare, DJ, Paul, B, Hilton, JBW   +12 more
core   +1 more source

Assessment of alterations in the structure and function of the enteric nervous system in a murine model of multiple sclerosis [PDF]

reservedLa sclerosi multipla (SM) è una malattia neurodegenerativa e demielinizzante di origine autoimmune che colpisce il sistema nervoso centrale (SNC).
PRIORE, ANTONIO
core  

Effects of Green Tea Epigallocatechin-3-Gallate (EGCG) On Proteolipid Protein (PLP) and Oligodendrocyte Transcription Factor 1 (Olig1) Expression in the Cerebral Cortex of Cuprizone Induced Multiple Sclerosis Mice; A Western Blot Study

Caspian Journal of Neurological Sciences, 2016
Background: The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system.
Mohammad-Reza Semnani, Farhad Mashayekhi, Mahnaz Azarnia, Zivar Salehi   +3 more
doaj  

Inhibition of Lin-11, Isl-1, and Mec‑3 Kinase (LIMK) Activity Attenuates Astrogliosis and Vascular Remodeling in an Experimental Model of Cuprizone-Induced Demyelination in Mice. [PDF]

ACS Pharmacol Transl Sci
Roy A, Pendbhaje S, Goyal D, Kumar H.
europepmc   +1 more source