Results 101 to 110 of about 8,969 (212)
Mediators of Inflammation, 2013 We recently demonstrated that sildenafil reduces the expression of cytokines, COX-2, and GFAP in a demyelinating model induced in wild-type (WT) mice.
Catarina Raposo +5 more
doaj +1 more source
P2x7 receptors control demyelination and inflammation in the cuprizone model
Brain, Behavior, & Immunity - Health, 2020 The contribution of P2x7 receptors to multiple sclerosis remains controversial, as both detrimental and beneficial effects resulting from P2x7 receptor loss-of-function have been reported in autoimmune models of the disease.
Ana Bernal-Chico +5 more
doaj +1 more source
Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor [PDF]
, 2015 In order to further investigate the molecular mechanisms that regulate oligodendrocyte (OC) survival, we utilized microarrays to characterize changes in OC gene expression after exposure to the cytokines neurotrophin3, insulin, or leukemia inhibitory ...
Alonzi +29 more
core +2 more sources
Folia Neuropathologica, 2017 The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system.
Mohammadreza Semnani +3 more
doaj +1 more source
Modeling multiple sclerosis in laboratory animals [PDF]
, 2018 Inflammatory demyelinating disease of the central nervous system is one of the most frequent causes of neurological disability in young adults. While in situ analysis and in vitro models do shed some light onto the processes of tissue damage and cellular
Becher, Burkhard +2 more
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Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease [PDF]
, 2010 It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease.
Angus M. Brown +10 more
core +2 more sources
Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. [PDF]
, 2014 Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation, demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells, is known to regulate T cell differentiation and migration in the periphery, but
Bannerman, Peter +10 more
core +3 more sources
Frontiers in Pharmacology, 2019 Growing evidence has implicated that myelin deficits and neuroinflammation are the coexisted pathological features that contribute to the mood swing and cognitive decline in major depressive disorder (MDD) and multiple sclerosis (MS).
Yanbo Zhang +8 more
doaj +1 more source
Protective effects of cannabidiol on cuprizone-induced demyelination in C57BL/6 mice
Journal of Contemporary Medical Sciences, 2017 Objective Experimental and clinical studies suggest that oxidative stress plays an important role in the pathogenesis of multiple sclerosis. In this study, we have investigated the effects of the non-psychoactive cannabinoid cannabidiol (CBD), which ...
Maryam Sajjadian +8 more
doaj
Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis. [PDF]
, 2013 BackgroundTherapeutic strategies that induce effective neuroprotection and enhance intrinsic repair mechanisms are central goals for future treatment of multiple sclerosis (MS), as well as other diseases.
Hannsun, Gemmy +9 more
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