Results 1 to 10 of about 94,021 (297)

Cuprizone-induced demyelination model mice exhibit antisocial maltreating behavior: an experimental animal study [PDF]

Encephalitis
Purpose The structural integrity of white matter in the human brain, including myelination, is important not only for brain pathology but also for cognitive functions, including social behavior.
Daejong Jeon, Sangwoo Kim, Sang Kun Lee, Kon Chu   +3 more
doaj   +2 more sources

Matrix metalloprotease-9 modulates microglial/macrophage responses in murine brain demyelination [PDF]

Acta Neuropathologica Communications
Multiple sclerosis (MS) is a chronic autoimmune disorder, in which the immune system targets the protective myelin sheath surrounding axons in the brain, spinal cord and optic nerve, leading to demyelination and ultimately neurodegeneration.
Eline Bernaerts, Amber De Visscher, Sam Vanherle, Marie Rutten, Fran Prenen, Nele Berghmans, Jana Van Broeckhoven, Hanne Meers, Mirre De Bondt, Febe Boudry, Sofie Knoops, Tania Mitera, Lien De Somer, Jeroen Bogie, Patrick Matthys, Jennifer Vandooren   +15 more
doaj   +2 more sources

IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination

Frontiers in Immunology, 2023
Previously we reported that a recombinant HSV-1 expressing murine IL-2 (HSV-IL-2) causes CNS demyelination in different strains of mice and in a T cell-dependent manner.
Satoshi Hirose, Shaohui Wang, Ujjaldeep Jaggi, Harry H. Matundan, Mihoko Kato, Xue-Ying Song, Sara J. Molesworth-Kenyon, Robert N. Lausch, Homayon Ghiasi   +8 more
doaj   +1 more source

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice. [PDF]

PLoS Pathogens, 2017
We have established two mouse models of central nervous system (CNS) demyelination that differ from most other available models of multiple sclerosis (MS) in that they represent a mixture of viral and immune triggers. In the first model, ocular infection
Dhong Hyun Lee, Mandana Zandian, Jane Kuo, Kevin R Mott, Shuang Chen, Moshe Arditi, Homayon Ghiasi   +6 more
doaj   +1 more source

Radiation Induced Demyelination in Cervical Spinal Cord of the Head and Neck Cancer Patients after Receiving Radiotherapy [PDF]

Journal of Biomedical Physics and Engineering, 2020
Background: Cervical spinal cord is important and radiosensitive. It is the most critical organ for the head and neck (H&N) cancer patients during radiotherapy.
H Goyal, N Singh, O P Gurjar, R K Tanwar
doaj   +1 more source

Demyelination of the Optic Nerve: An Underlying Factor in Glaucoma?

Frontiers in Aging Neuroscience, 2021
Neurodegenerative disorders are characterized by typical neuronal degeneration and axonal loss in the central nervous system (CNS). Demyelination occurs when myelin or oligodendrocytes experience damage.
Jingfei Xue, Yingting Zhu, Zhe Liu, Jicheng Lin, Yangjiani Li, Yiqing Li, Yehong Zhuo   +6 more
doaj   +1 more source

Effects of Bone Marrow Mesenchymal Stem Cells on Myelin Repair and Emotional Changes of a Cuprizone-Induced Demyelination Model

Journal of Integrative Neuroscience, 2023
Background: Multiple sclerosis (MS) is an autoimmune disease for which bone marrow mesenchymal stem cells (BM-MSCs) have become one of the most promising tools for treatment.
Chu Lei, Haowei Chen, Kangning Chen
doaj   +1 more source

Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis

iScience, 2020
Summary: We previously reported that infection of different mouse strains with a recombinant HSV-1 expressing IL-2 (HSV-IL-2) caused CNS demyelination.
Satoshi Hirose, Pedram Shafiei Jahani, Shaohui Wang, Ujjaldeep Jaggi, Kati Tormanen, Jack Yu, Mihoko Kato, Omid Akbari, Homayon Ghiasi   +8 more
doaj   +1 more source

(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut–microbiota–brain axis

Neurobiology of Disease, 2022
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. We recently reported that the new antidepressant (R)-ketamine could ameliorate the disease progression in experimental autoimmune encephalomyelitis ...
Xingming Wang, Lijia Chang, Xiayun Wan, Yunfei Tan, Youge Qu, Jiajing Shan, Yong Yang, Li Ma, Kenji Hashimoto   +8 more
doaj   +1 more source

Butyrate suppresses demyelination and enhances remyelination

Journal of Neuroinflammation, 2019
Background The association of gut microbiota and diseases of the central nervous system (CNS), including multiple sclerosis (MS), has attracted much attention.
Tong Chen, Daisuke Noto, Yasunobu Hoshino, Miho Mizuno, Sachiko Miyake   +4 more
doaj   +1 more source