Results 11 to 20 of about 106,551 (295)
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Myelin sheaths insulate the neuronal axons and speed the transmission of electrical impulses. The demyelination process occurs in many human diseases, including multiple sclerosis (MS).
Ze Zhang, Chenjie Pan, Xiaodong Wang
exaly +2 more sources
IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination
Frontiers in Immunology, 2023 Previously we reported that a recombinant HSV-1 expressing murine IL-2 (HSV-IL-2) causes CNS demyelination in different strains of mice and in a T cell-dependent manner.
Satoshi Hirose +8 more
doaj +1 more source
Molecular Neurodegeneration, 2022 Background The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis.
M. Zirngibl +4 more
semanticscholar +1 more source
Cell Reports, 2023 SUMMARY Demyelination is a hallmark of multiple sclerosis, leukoencephalopathies, cerebral vasculopathies, and several neurodegenerative diseases. The cuprizone mouse model is widely used to simulate demyelination and remyelination occurring in these ...
Jinchao Hou +17 more
semanticscholar +1 more source
Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia.
NEJM Evidence, 2023 Osmotic Demyelination Syndrome and HyponatremiaThe authors estimated the frequency of occurrence of osmotic demyelination syndrome (ODS) after correction of hyponatremia (i.e., serum sodium
T. MacMillan +10 more
semanticscholar +1 more source
Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice. [PDF]
PLoS Pathogens, 2017 We have established two mouse models of central nervous system (CNS) demyelination that differ from most other available models of multiple sclerosis (MS) in that they represent a mixture of viral and immune triggers. In the first model, ocular infection
Dhong Hyun Lee +6 more
doaj +1 more source
Journal of Neurovirology, 2003 A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC papovirus destruction of oligodendrocytes, and subacute sclerosing panencephalitis, an invariably fatal ...
Fazakerley, JK, Walker, R
openaire +4 more sources
Radiation Induced Demyelination in Cervical Spinal Cord of the Head and Neck Cancer Patients after Receiving Radiotherapy [PDF]
Journal of Biomedical Physics and Engineering, 2020 Background: Cervical spinal cord is important and radiosensitive. It is the most critical organ for the head and neck (H&N) cancer patients during radiotherapy.
H Goyal, N Singh, O P Gurjar, R K Tanwar
doaj +1 more source
Demyelination of the Optic Nerve: An Underlying Factor in Glaucoma?
Frontiers in Aging Neuroscience, 2021 Neurodegenerative disorders are characterized by typical neuronal degeneration and axonal loss in the central nervous system (CNS). Demyelination occurs when myelin or oligodendrocytes experience damage.
Jingfei Xue +6 more
doaj +1 more source
CNS Neuroscience & Therapeutics, 2022 Multiple sclerosis (MS) still maintains increasing prevalence and poor prognosis, while glucagon‐like peptide‐1 receptor (GLP‐1R) agonists show excellent neuroprotective capacities recently. Thus, we aim to evaluate whether the GLP‐1R agonist liraglutide
Shuang Song +8 more
semanticscholar +1 more source