Results 11 to 20 of about 91,619 (289)
Journal of Neurovirology, 2003 A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC papovirus destruction of oligodendrocytes, and subacute sclerosing panencephalitis, an invariably fatal ...
Fazakerley, JK, Walker, R
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Interruptible demyelination in avian riboflavin deficient neuropathy
Cell & BioscienceBackground and aims The evolution of demyelination in individual internodes remains unclear although it has been noticed the paranodal demyelination precedes internodal demyelination in neuropathies with diverse aetiologies.
Zhao Cai
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Detecting early brain susceptibility changes before demyelination in cuprizone mouse model using quantitative susceptibility mapping (QSM) [PDF]
NeuroImageMultiple sclerosis (MS) is a neurological disease that affects the central nervous system through demyelination and inflammation. Animal model, including the cuprizone (CPZ) model, provides a robust platform for studying demyelination and remyelination ...
Xinyue Han +5 more
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Strain differences in cuprizone induced demyelination
Cell & Bioscience, 2017 Background Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide.
Qili Yu +6 more
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A New Model of Cuprizone-Mediated Demyelination/Remyelination
ASN Neuro, 2014 In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Wendy Macklin, Daniela C Popescu
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Demyelination following anti-TNFɑ
Objective: To establish the incidence of demyelination in patients who have received anti-tumour necrosis factor (anti-TNFɑ) therapy, through analysis of adverse events reported in a prospective cohort of patients receiving biological therapies. Methods:
Hyrich, Kimme
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IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination
Frontiers in Immunology, 2023 Previously we reported that a recombinant HSV-1 expressing murine IL-2 (HSV-IL-2) causes CNS demyelination in different strains of mice and in a T cell-dependent manner.
Satoshi Hirose +8 more
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Demyelination and Remyelination
Advances in NeurobiologyMyelinating oligodendrocytes and oligodendrocyte precursor cells (OPCs) make up half the cells in the central nervous system and are affected by and contribute to all neurological diseases. The pathology of myelinating oligodendrocytes is fundamentally characterized by myelin disruption and loss, termed demyelination, whereas that of OPCs is ...
Niu, Jianqin +3 more
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, 2022 Demyelination disorders are among the most frequent neurological conditions. Types of these disorders include multiple sclerosis, Guillain Barré syndrome, diabetic peripheral neuropathy, entrapment neuropathies, and others, all of which can result in ...
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Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice. [PDF]
PLoS Pathogens, 2017 We have established two mouse models of central nervous system (CNS) demyelination that differ from most other available models of multiple sclerosis (MS) in that they represent a mixture of viral and immune triggers. In the first model, ocular infection
Dhong Hyun Lee +6 more
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