Results 11 to 20 of about 94,021 (297)

Virus Demyelination [PDF]

Journal of Neurovirology, 2003
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC papovirus destruction of oligodendrocytes, and subacute sclerosing panencephalitis, an invariably fatal ...
Fazakerley, JK, Walker, R
core   +7 more sources

Interruptible demyelination in avian riboflavin deficient neuropathy

Cell & Bioscience
Background and aims The evolution of demyelination in individual internodes remains unclear although it has been noticed the paranodal demyelination precedes internodal demyelination in neuropathies with diverse aetiologies.
Zhao Cai
doaj   +2 more sources

A New Model of Cuprizone-Mediated Demyelination/Remyelination

ASN Neuro, 2014
In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs, Kathryn K. Bercury, Daniela C. Popescu, S. Priya Narayanan, Wendy B. Macklin   +4 more
doaj   +2 more sources

Demyelination and Remyelination

Advances in Neurobiology
Myelinating oligodendrocytes and oligodendrocyte precursor cells (OPCs) make up half the cells in the central nervous system and are affected by and contribute to all neurological diseases. The pathology of myelinating oligodendrocytes is fundamentally characterized by myelin disruption and loss, termed demyelination, whereas that of OPCs is ...
Niu, Jianqin, Verkhratsky, Alexei; id_orcid 0000-0003-2592-9898, Butt, Arthur, Yi, Chenju   +3 more
openaire   +2 more sources

Demyelination Disorders [PDF]

, 2022
Demyelination disorders are among the most frequent neurological conditions. Types of these disorders include multiple sclerosis, Guillain Barré syndrome, diabetic peripheral neuropathy, entrapment neuropathies, and others, all of which can result in ...

core   +1 more source

Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis

Neurobiology of Disease, 2021
Myelin consists of several layers of tightly compacted membranes that form an insulating sheath around axons. These membranes are highly enriched in cholesterol, which is essential for the myelination process.
Xinjian Zhu, Yuanyuan Yao, Yang Hu, Jiurong Yang, Canyu Zhang, Yuqi He, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan   +9 more
doaj   +1 more source

Gut Microbiota-Derived Indole-3-Acetaldehyde Contributes to the Disease-Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis. [PDF]

Adv Sci (Weinh)
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Han X, Ding J, Pan Z, He W, Kang X, Zhao C, Li Y, Wu D, Li H, Ren K, Lin J, Guo J.   +11 more
europepmc   +2 more sources

Conduction in segmentally demyelinated mammalian central axons. [PDF]

, 1997
The prominent symptoms associated with central demyelinating diseases such as multiple sclerosis (MS) are primarily caused by conduction deficits in affected axons.
Paul A. Felts, Baker, Theresa A., Theresa A. Baker, Felts, PA, Smith, KJ, Smith, Kenneth J., Felts, Paul A.; id_orcid, Kenneth J. Smith, Baker, TA   +8 more
core   +1 more source

Dynamic response of microglia/macrophage polarization following demyelination in mice

Journal of Neuroinflammation, 2019
Background The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function.
Tianci Chu, Yi Ping Zhang, Zhisen Tian, Chuyuan Ye, Mingming Zhu, Lisa B. E. Shields, Maiying Kong, Gregory N. Barnes, Christopher B. Shields, Jun Cai   +9 more
doaj   +1 more source

Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain

Neurobiology of Disease, 2023
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS.
Xingming Wang, Akifumi Eguchi, Yong Yang, Lijia Chang, Xiayun Wan, Jiajing Shan, Youge Qu, Li Ma, Chisato Mori, Jianjun Yang, Kenji Hashimoto   +10 more
doaj   +1 more source