Results 21 to 30 of about 106,551 (295)

Effects of Bone Marrow Mesenchymal Stem Cells on Myelin Repair and Emotional Changes of a Cuprizone-Induced Demyelination Model

Journal of Integrative Neuroscience, 2023
Background: Multiple sclerosis (MS) is an autoimmune disease for which bone marrow mesenchymal stem cells (BM-MSCs) have become one of the most promising tools for treatment.
Chu Lei, Haowei Chen, Kangning Chen
doaj   +1 more source

Association of CNS demyelination and COVID-19 infection: an updated systematic review

Journal of Neurology, 2021
Since the declaration of COVID-19 pandemic, several case reports of demyelination of both peripheral and central nervous systems have been published. The association between CNS demyelination and viral infection has long been documented, and this link ...
I. Ismail, S. Salama
semanticscholar   +1 more source

Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis

iScience, 2020
Summary: We previously reported that infection of different mouse strains with a recombinant HSV-1 expressing IL-2 (HSV-IL-2) caused CNS demyelination.
Satoshi Hirose, Pedram Shafiei Jahani, Shaohui Wang, Ujjaldeep Jaggi, Kati Tormanen, Jack Yu, Mihoko Kato, Omid Akbari, Homayon Ghiasi   +8 more
doaj   +1 more source

Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis

Neurobiology of Disease, 2021
Myelin consists of several layers of tightly compacted membranes that form an insulating sheath around axons. These membranes are highly enriched in cholesterol, which is essential for the myelination process.
Xinjian Zhu, Yuanyuan Yao, Yang Hu, Jiurong Yang, Canyu Zhang, Yuqi He, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan   +9 more
doaj   +1 more source

Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination

Journal of Neuroscience, 2020
Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a copper chelator, is widely used to study demyelination and remyelination in the CNS, in the context of MS.
Priya Jhelum, Eva Santos-Nogueira, Wulin Teo, A. Haumont, Isadora Lenoël, P. Stys, S. David   +6 more
semanticscholar   +1 more source

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

Nature Neuroscience, 2020
Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new ...
Sarah A. Neely, Jill M Williamson, Anna Klingseisen, Lida Zoupi, J. Early, Anna C. Williams, D. Lyons   +6 more
semanticscholar   +1 more source

Immunological Demyelination Triggers Macrophage/Microglial Cells Activation without Inducing Astrogliosis

Clinical and Developmental Immunology, 2013
The glial scar formed by reactive astrocytes and axon growth inhibitors associated with myelin play important roles in the failure of axonal regeneration following central nervous system (CNS) injury.
Frank Cloutier, Ilse Sears-Kraxberger, Krista Keachie, Hans S. Keirstead   +3 more
doaj   +1 more source

Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

Journal of Neurology Neurosurgery & Psychiatry, 2017
Objective We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.
S. Ramanathan, S. Mohammad, E. Tantsis, Tina Nguyen, V. Merheb, V. Fung, O. White, S. Broadley, J. Lechner-Scott, S. Vucic, A. Henderson, M. Barnett, S. Reddel, F. Brilot, R. Dale   +14 more
semanticscholar   +1 more source

Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination

ASN Neuro, 2012
In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination.
Norah Hibbits, Jun Yoshino, Tuan Q. Le, Regina C. Armstrong   +3 more
doaj   +1 more source

CHARACTERIZATION OF SIGNAL CONDUCTION ALONG DEMYELINATED AXONS BY ACTION-POTENTIAL-ENCODED SECOND HARMONIC GENERATION [PDF]

Journal of Innovative Optical Health Sciences, 2014
Action-potential-encoded optical second harmonic generation (SHG) has been recently proposed for use in detecting the axonal damage in patients with demyelinating diseases.
ZHI-HUI LUO, JIANG-XU CHEN, YI-MEI HUANG, HONG-QIN YANG, JU-QIANG LIN, HUI LI, SHU-SEN XIE   +6 more
doaj   +1 more source