Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice
Nature Communications, 2022 Ischemic stroke can cause secondary demyelination. Whether phagocytic astrocytes can contribute to such demyelination is unclear. Here, the authors show that lipocalin-2 (LCN-2) expression increased in astrocytes upon injury.
Ting Wan +10 more
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Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination
ASN Neuro, 2012 In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination.
Norah Hibbits +3 more
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Journal of Clinical Pathology, 2006 A diagnosis of demyelination carries important therapeutic and prognostic implications. In most cases the diagnosis is made clinically, and involvement of the histopathologist is largely confined to postmortem confirmation and clinicopathological correlation.
openaire +3 more sources
CHARACTERIZATION OF SIGNAL CONDUCTION ALONG DEMYELINATED AXONS BY ACTION-POTENTIAL-ENCODED SECOND HARMONIC GENERATION [PDF]
Journal of Innovative Optical Health Sciences, 2014 Action-potential-encoded optical second harmonic generation (SHG) has been recently proposed for use in detecting the axonal damage in patients with demyelinating diseases.
ZHI-HUI LUO +6 more
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Exogenous Antioxidants in Remyelination and Skeletal Muscle Recovery
Biomedicines, 2022 Inflammatory, oxidative, and autoimmune responses cause severe damage to the nervous system inducing loss of myelin layers or demyelination. Even though demyelination is not considered a direct cause of skeletal muscle disease there is extensive damage ...
Ricardo Julián Cabezas Perez +2 more
doaj +1 more source
Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease [PDF]
, 2010 It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease.
Angus M. Brown +10 more
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FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. [PDF]
, 2014 BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration for treatment of patients with the relapsing-remitting form of the human demyelinating disease multiple sclerosis.
Blanc, Caroline A +2 more
core +1 more source
Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis [PDF]
, 2018 Indexación: Scopus.Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring.
Albornoz, E. +13 more
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Molecular Pain, 2010 Background Although neuropathic pain is frequently observed in demyelinating diseases such as Guillain-Barré syndrome and multiple sclerosis, the molecular basis for the relationship between demyelination and neuropathic pain behaviors is poorly ...
Aoki Junken +8 more
doaj +1 more source
Journal of Neuroinflammation, 2023 Demyelination occurs in multiple central nervous system (CNS) disorders and is tightly associated with neuroinflammation. Pyroptosis is a form of pro-inflammatory and lytic cell death which has been observed in CNS diseases recently.
Yao Wang +10 more
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