Results 21 to 30 of about 94,021 (297)
Journal of Neuroinflammation, 2020 Background Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss.
Man Chen +10 more
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Clinical and Developmental Immunology, 2013 The glial scar formed by reactive astrocytes and axon growth inhibitors associated with myelin play important roles in the failure of axonal regeneration following central nervous system (CNS) injury.
Frank Cloutier +3 more
doaj +1 more source
Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice
Nature Communications, 2022 Ischemic stroke can cause secondary demyelination. Whether phagocytic astrocytes can contribute to such demyelination is unclear. Here, the authors show that lipocalin-2 (LCN-2) expression increased in astrocytes upon injury.
Ting Wan +10 more
doaj +1 more source
Immunopathogenesis of cortical demyelination in Multiple Sclerosis [PDF]
, 2015 Cortical demyelination is a key pathological feature of multiple sclerosis (MS) and clinically linked to cognitive deficits and disability progression. Extensive band-like subpial demyelination is even a specific feature of the disease.
Lagumersindez Denis, Nielsen +2 more
core +1 more source
Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination
ASN Neuro, 2012 In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination.
Norah Hibbits +3 more
doaj +1 more source
Journal of Clinical Pathology, 2006 A diagnosis of demyelination carries important therapeutic and prognostic implications. In most cases the diagnosis is made clinically, and involvement of the histopathologist is largely confined to postmortem confirmation and clinicopathological correlation.
openaire +3 more sources
Outcomes after early administration of plasma exchange in pediatric central nervous system inflammatory demyelination. [PDF]
, 2015 The use of plasma exchange has been described in steroid-refractory central nervous system inflammatory demyelination in adults, but less has been published regarding its use in children and adolescents.
Banwell, Brenda +2 more
core +1 more source
Demyelination and oligodendrocytes
Rinsho Shinkeigaku, 2011 Although neurological sequelae are attributable to poor regeneration of the central nervous system, oligodendrocytes demonstrate robust regenerative response even in adults. Accumulating evidence indicates that the glial cells identified by surface expression of the proteoglycan NG2 are the cellular source of newly-developed oligodendrocytes following ...
Itoh, Takayuki +4 more
openaire +3 more sources
CHARACTERIZATION OF SIGNAL CONDUCTION ALONG DEMYELINATED AXONS BY ACTION-POTENTIAL-ENCODED SECOND HARMONIC GENERATION [PDF]
Journal of Innovative Optical Health Sciences, 2014 Action-potential-encoded optical second harmonic generation (SHG) has been recently proposed for use in detecting the axonal damage in patients with demyelinating diseases.
ZHI-HUI LUO +6 more
doaj +1 more source
Exogenous Antioxidants in Remyelination and Skeletal Muscle Recovery
Biomedicines, 2022 Inflammatory, oxidative, and autoimmune responses cause severe damage to the nervous system inducing loss of myelin layers or demyelination. Even though demyelination is not considered a direct cause of skeletal muscle disease there is extensive damage ...
Ricardo Julián Cabezas Perez +2 more
doaj +1 more source