Results 31 to 40 of about 106,551 (295)

Exogenous Antioxidants in Remyelination and Skeletal Muscle Recovery

Biomedicines, 2022
Inflammatory, oxidative, and autoimmune responses cause severe damage to the nervous system inducing loss of myelin layers or demyelination. Even though demyelination is not considered a direct cause of skeletal muscle disease there is extensive damage ...
Ricardo Julián Cabezas Perez, Marco Fidel Ávila Rodríguez, Doris Haydee Rosero Salazar   +2 more
doaj   +1 more source

Demyelinating diseases [PDF]

Journal of Clinical Pathology, 2006
A diagnosis of demyelination carries important therapeutic and prognostic implications. In most cases the diagnosis is made clinically, and involvement of the histopathologist is largely confined to postmortem confirmation and clinicopathological correlation.
openaire   +3 more sources

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Nature Communications, 2019
Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system, and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory diseases such as multiple sclerosis (MS) remyelination is often incomplete.
Leslie A. Kirby, Jing Jin, J. Cardona, Matthew D. Smith, Kyle A. Martin, Jingya Wang, Hayley J Strasburger, Leyla R Herbst, M. Alexis, J. Karnell, Todd S. Davidson, Ranjan Dutta, J. Goverman, D. Bergles, P. Calabresi   +14 more
semanticscholar   +1 more source

Demyelination and oligodendrocytes

Rinsho Shinkeigaku, 2011
Although neurological sequelae are attributable to poor regeneration of the central nervous system, oligodendrocytes demonstrate robust regenerative response even in adults. Accumulating evidence indicates that the glial cells identified by surface expression of the proteoglycan NG2 are the cellular source of newly-developed oligodendrocytes following ...
Itoh, Takayuki, Horiuchi, Makoto, Wakayama, Kouji, Itoh, Aki, Pleasure, David   +4 more
openaire   +3 more sources

Mild Traumatic Brain Injury Results in Significant and Lasting Cortical Demyelination

Frontiers in Neurology, 2022
Despite contributing to neurocognitive deficits, intracortical demyelination after traumatic brain injury (TBI) is understudied. This study uses magnetic resonance imaging (MRI) to map intracortical myelin and its change in healthy controls and after ...
Sean O. Mahoney, Nahian F. Chowdhury, Van Ngo, Phoebe Imms, Andrei Irimia, Andrei Irimia   +5 more
doaj   +1 more source

Autotaxin and lysophosphatidic acid₁ receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine

Molecular Pain, 2010
Background Although neuropathic pain is frequently observed in demyelinating diseases such as Guillain-Barré syndrome and multiple sclerosis, the molecular basis for the relationship between demyelination and neuropathic pain behaviors is poorly ...
Aoki Junken, Niwa Masami, Ueda Mutsumi, yano Ryo, Matsushita Yosuke, Uchida Hitoshi, Nagai Jun, Chun Jerold, Ueda Hiroshi   +8 more
doaj   +1 more source

Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination

Science
Alzheimer’s disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex chromosomes and gonads in demyelination and AD.
Chloe Lopez-Lee, Lay Kodama, Li Fan, Daphne Zhu, Jingjie Zhu, M. Wong, Pearly Ye, Kendra Norman, Nessa R. Foxe, Laraib Ijaz, Fangmin Yu, Hao Chen, G. Carling, E. R. Torres, Rachel D. Kim, Dena B. Dubal, Shane A. Liddelow, Subhash C. Sinha, Wenjie Luo, Li Gan   +19 more
semanticscholar   +1 more source

Clinical manifestations and imaging features of white matter demyelination in older patients

Journal of International Medical Research, 2020
Objective To investigate the clinical manifestations and imaging features of older patients with white matter demyelination diagnosed by magnetic resonance imaging (MRI).
Jian Li, Yi-Ming Zhao
doaj   +1 more source

Central Pontine Myelinosis and Osmotic Demyelination Syndrome.

Deutsches Ärzteblatt International, 2019
BACKGROUND Osmotic demyelination syndrome (ODS), which embraces central pontine myelinolysis (CPM) and extrapontine myelinosis (EPM), is often underdiagnosed in clinical practice, but can be fatal.
J. Lambeck, M. Hieber, A. Dressing, W. Niesen   +3 more
semanticscholar   +1 more source

Secondary parkinsonism due to osmotic demyelination syndrome: a case report

The Egyptian Journal of Internal Medicine, 2015
Hyponatremia is a common medical problem often found in the elderly and is due to poor intake, medical comorbidities, and medications. Central to the management of this condition is the use of normal and hypertonic saline, besides the use of ...
Waseem R Dar, Najeeb U Sofi, Muzamil Latief, Imtiyaz A Dar, Moomin Hussain   +4 more
doaj   +1 more source