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The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay
Frontiers in Cellular Neuroscience, 2020 Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn +8 more
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Frontiers in Cellular Neuroscience, 2023 IntroductionProtein kinase type C-ε (PKCε) plays an important role in the sensitization of primary afferent nociceptors, promoting mechanical hyperalgesia. In accordance, we showed that PKCε is present in sensory neurons of the peripheral nervous system (
Tasnim Mohamed +4 more
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Citrullination – small change with a great consequence [PDF]
, 2013 Citrullination is one of the possible post-translational modifications of proteins. It is based on a conversion of L-arginine residue (L-Arg) to L-citrulline residue (L-Cit). The reaction is catalyzed by peptidylarginine deiminases (PAD). The change of L-
Gogól Mariusz
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Frontiers in Neurology, 2018 Myelin sensitive MRI techniques, such as diffusion tensor imaging and myelin water imaging, have previously been used to reveal changes in myelin after sports-related concussions.
Alexander M. Weber +14 more
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Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis. [PDF]
, 2019 CD8+ T cells are believed to play an important role in multiple sclerosis (MS), yet their role in MS pathogenesis remains poorly defined. Although myelin proteins are considered potential autoantigenic targets, prior studies of myelin-reactive CD8+ T ...
Calabresi, Peter A +5 more
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On the stability and growth of single myelin figures
, 2005 Myelin figures are long thin cylindrical structures that typically grow as a dense tangle when water is added to the concentrated lamellar phase of certain surfactants.
A. Filippov +6 more
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Oligodendrocyte Development and Implication in Perinatal White Matter Injury
Frontiers in Cellular Neuroscience, 2021 Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events.
Mahsa Motavaf +4 more
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Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain. [PDF]
, 2015 BackgroundIschemia, white matter injury, and Alzheimer's disease (AD) pathologies often co-exist in aging brain. How one condition predisposes to, interacts with, or perhaps causes the others remains unclear.ObjectivesTo better understand the link ...
Ander, Bradley P +7 more
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Neuroinflammation and myelin status in Alzheimer’s disease, Parkinson’s disease, and normal aging brains: A small sample study [PDF]
, 2019 Microglia and astrocytes play important roles in mediating the immune processes and nutritional support in the central nervous system (CNS). Neuroinflammation has been indicated in the progression of neurodegenerative diseases Alzheimer’s disease (AD ...
Benzinger, Tammie L. S. +7 more
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Neurobiology of DiseaseAstrocytic iron metabolism is essential for maintaining central nervous system (CNS) homeostasis, particularly in the context of neurodegenerative and demyelinating disorders such as multiple sclerosis (MS).
Karishma G. Kedari +5 more
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