Results 41 to 50 of about 170,216 (297)

Protein kinase C epsilon activation regulates proliferation, migration, and epithelial to mesenchymal-like transition in rat Schwann cells

Frontiers in Cellular Neuroscience, 2023
IntroductionProtein kinase type C-ε (PKCε) plays an important role in the sensitization of primary afferent nociceptors, promoting mechanical hyperalgesia. In accordance, we showed that PKCε is present in sensory neurons of the peripheral nervous system (
Tasnim Mohamed, Alessandra Colciago, Marina Montagnani Marelli, Roberta Manuela Moretti, Valerio Magnaghi   +4 more
doaj   +1 more source

Pathological Insights From Quantitative Susceptibility Mapping and Diffusion Tensor Imaging in Ice Hockey Players Pre and Post-concussion

Frontiers in Neurology, 2018
Myelin sensitive MRI techniques, such as diffusion tensor imaging and myelin water imaging, have previously been used to reveal changes in myelin after sports-related concussions.
Alexander M. Weber, Alexander M. Weber, Anna Pukropski, Christian Kames, Christian Kames, Michael Jarrett, Michael Jarrett, Shiroy Dadachanji, Jack Taunton, David K. B. Li, David K. B. Li, David K. B. Li, Alexander Rauscher, Alexander Rauscher, Alexander Rauscher   +14 more
doaj   +1 more source

Myelin-Associated Glycoprotein Is a Myelin Signal that Modulates the Caliber of Myelinated Axons [PDF]

The Journal of Neuroscience, 1998
Myelination increases neuronal conduction velocity through its insulating properties and an unidentified extrinsic effect that increases axonal caliber. Although it is well established that demyelination can cause axonal atrophy, the myelin molecule that regulates axonal caliber is not known.
X, Yin, T O, Crawford, J W, Griffin, P h, Tu, V M, Lee, C, Li, J, Roder, B D, Trapp   +7 more
openaire   +2 more sources

Structure of myelin P2 protein from equine spinal cord [PDF]

, 2005
Equine P2 protein has been isolated from horse spinal cord and its structure determined to 2.1 Å. Since equine myelin is a viable alternative to bovine tissue for large-scale preparations, characterization of the proteins from equine spinal cord ...
Riboldi-Tunnicliffe, A., Riboldi-Tunnicliffe, A, Freer, A.A., Hunter, DJB, Hunter, D.J.B., Griffiths, IR, Roszak, A.W., Macmaster, R, Roszak, AW, Macmaster, R., Griffiths, I.R., Freer, AA   +11 more
core   +1 more source

avdvorak/myelin-atlas: version 1.0.1

, 2020
Example code for the analysis pipeline used to create the structural template and quantitative myelin water imaging atlases for An atlas for human brain myelin content throughout the adult life span https://www.nature.com/articles/s41598-020-79540-
Dvorak, Adam V.
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay

Frontiers in Cellular Neuroscience, 2020
Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn, Sophie B. Siems, Kathrin Kusch, Dörte Hesse, Ramona B. Jung, Thomas Liepold, Marina Uecker, Ting Sun, Hauke B. Werner   +8 more
doaj   +1 more source

Myelination and mTOR [PDF]

Glia, 2017
AbstractMyelinating cells surround axons to accelerate the propagation of action potentials, to support axonal health, and to refine neural circuits. Myelination is metabolically demanding and, consistent with this notion, mTORC1—a signaling hub coordinating cell metabolism—has been implicated as a key signal for myelination.
Gianluca Figlia, Daniel Gerber, Ueli Suter   +2 more
openaire   +4 more sources

c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. [PDF]

, 2012
The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration.
Jenkins, Billy, Turmaine, Mark, Mirsky, Rhona, Quintes, Susanne, Wicher, GK, Wilton, Daniel K., Chabrol, Elodie, Latouche, Morwena, Chabrol, E, Banerjee, Ambily, Behrens, A, Mirsky, R, Woodhoo, Ashwin, Jenkins, B, Mitter, Richard, Quintes, S, Turmaine, M, Greensmith, L, Jessen, Kristján R., Wicher, Grzegorz K., Woodhoo, A, Mitter, R, Behrens, Axel, Raivich, Gennadij, Wicher, Grzegorz K.,, Latouche, M, Banerjee, Annbily, Arthur-Farraj, PJ, Wilton, DK, Banerjee, A, Rahman, Mary, Jessen, KR, Rahman, M, Arthur-Farraj, Peter J., Greensmith, Linda, Raivich, G   +35 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source