Results 61 to 70 of about 174,175 (299)

Prolonged Environmental Enrichment Promotes Developmental Myelination

Frontiers in Cell and Developmental Biology, 2021
Postnatal neurodevelopment is profoundly influenced by environmental experiences. Environmental enrichment is a commonly used experimental paradigm that has uncovered numerous examples of experience-dependent plasticity in health and disease.
Evan Z. Goldstein, Vera Pertsovskaya, Thomas A. Forbes, Jeffrey L. Dupree, Vittorio Gallo   +4 more
doaj   +1 more source

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes [PDF]

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
Attwell, D., Koodziejczyk, Karolina, Kolodziejczyk, K., Wade, A., Kradttir, Ragnhildur, Wade, Anna, Karadottir, R., Hamilton, Nicola B.; id_orcid, Attwell, David, Hamilton, N. B.   +9 more
core   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Chemogenetic Schwann cell activation impairs early myelination and triggers adult demyelination in the peripheral nervous system

Frontiers in Cellular Neuroscience
Schwann cells (SCs), the myelin-forming glia of the peripheral nervous system (PNS), are essential for nerve development and maintenance; however, the contribution of Ca2+ signaling to their maturation and long-term stability remains poorly understood ...
Jazmin G. Corral, Veronica T. Cheli, Diara A. Santiago-Gonzalez, Karishma G. Kedari, Pablo M. Paez   +4 more
doaj   +1 more source

T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain in Relation to Increased Microglial Reactivity and Cognitive Decline

Frontiers in Immunology, 2021
Normal aging is characterized by declines in processing speed, learning, memory, and executive function even in the absence of neurodegenerative diseases such as Alzheimer's Disease (AD). In normal aging monkeys and humans, neuronal loss does not account
Katelyn V. Batterman, Payton E. Cabrera, Tara L. Moore, Tara L. Moore, Tara L. Moore, Douglas L. Rosene, Douglas L. Rosene   +6 more
doaj   +1 more source

The Characterization of Disordered Membrane-Binding Proteins of Myelin. A Biophysical Approach [PDF]

, 2018
Myelin is a multilayered lipid-rich structure that surrounds selected axonal segments in the central and peripheral nervous systems (CNS and PNS, respectively).
Raasakka, Arne, McAleer, Jeremy P., Fan, Jun, Denvir, James, Roar, Bryanna, Primerano, Donald A.   +5 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

A preclinical mice model of multiple sclerosis based on the toxin-induced double-site demyelination of callosal and cerebellar fibers

Biological Research
Background Multiple sclerosis (MS) is an irreversible progressive CNS pathology characterized by the loss of myelin (i.e. demyelination). The lack of myelin is followed by a progressive neurodegeneration triggering symptoms as diverse as fatigue, motor ...
Sebastián Vejar, Ignacio S. Pizarro, Raúl Pulgar-Sepúlveda, Sinay C. Vicencio, Andrés Polit, Cristian A. Amador, Rodrigo del Rio, Rodrigo Varas, Juan A. Orellana, Fernando C. Ortiz   +9 more
doaj   +1 more source

Dendropanax morbiferus leaf extract facilitates oligodendrocyte development [PDF]

Royal Society Open Science, 2019
Treatment of multiple sclerosis is effective when anti-inflammatory, neuroprotective and regenerative strategies are combined. Dendropanax morbiferus (DM) has anti-inflammatory, anti-oxidative properties, which may be beneficial for multiple sclerosis ...
Ji-Young Kim, Ju-Young Yoon, Yuki Sugiura, Soo-Kyoung Lee, Jae-Don Park, Gyun-Jee Song, Hyun-Jeong Yang   +6 more
doaj   +1 more source

Advances in noninvasive myelin imaging [PDF]

, 2017
Myelin is important for the normal development and healthy function of the nervous system. Recent developments in MRI acquisition and tissue modeling aim to provide a better characterization and more specific markers for myelin.
Johansen-Berg, Heidi, Sampaio-Baptista, Cassandra, Heath, Florence, Samuel A. Hurley, Heidi Johansen-Berg, Cassandra Sampaio-Baptista, Florence Heath, Hurley, Samuel A.   +7 more
core   +1 more source