Results 61 to 70 of about 170,216 (297)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Chemogenetic Schwann cell activation impairs early myelination and triggers adult demyelination in the peripheral nervous system

Frontiers in Cellular Neuroscience
Schwann cells (SCs), the myelin-forming glia of the peripheral nervous system (PNS), are essential for nerve development and maintenance; however, the contribution of Ca2+ signaling to their maturation and long-term stability remains poorly understood ...
Jazmin G. Corral, Veronica T. Cheli, Diara A. Santiago-Gonzalez, Karishma G. Kedari, Pablo M. Paez   +4 more
doaj   +1 more source

Dendropanax morbiferus leaf extract facilitates oligodendrocyte development [PDF]

Royal Society Open Science, 2019
Treatment of multiple sclerosis is effective when anti-inflammatory, neuroprotective and regenerative strategies are combined. Dendropanax morbiferus (DM) has anti-inflammatory, anti-oxidative properties, which may be beneficial for multiple sclerosis ...
Ji-Young Kim, Ju-Young Yoon, Yuki Sugiura, Soo-Kyoung Lee, Jae-Don Park, Gyun-Jee Song, Hyun-Jeong Yang   +6 more
doaj   +1 more source

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis [PDF]

, 2013
PMCID: PMC3856490This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Amor, Sandra, Gerritsen, W.H., Victor, M. (Marion), Peferoen-Baert, R., Gerritsen, Wouter, Kimberley Ummenthum, Reijerkerk, Arie, Puentes, F. (Fabiola), Baker, D., Amor, S, Fabiola Puentes, Ruth Huizinga, van der Star, BJ, Sandra Amor, van der Valk, P, Gerritsen, W. (Wouter), David Baker, van der Star, B.J., Regina Peferoen-Baert, Baker, David, Markus Kipp, Marion Victor, Amor, S., Star, B.J. (Baukje) van der, Arie Reijerkerk, Puentes, F., Pryce, Gareth, Baker, D, Victor, Marion, Pryce, K. (Karena), Victor, M., Victor, M, Peferoen-Baert, R, Paul van der Valk, Kipp, M., Ummenthum, K, Victor, Marion Barbara, Beyer, C. (Cordian), Huizinga, R., Baker, D.A. (David), Reijerkerk, A., van der Star, Baukje J., Peferoen-Baert, Regina, Ummenthum, K. (Kimberley), Puentes, F, Amor, S. (Sandra), Ummenthum, Kimberley, Cordian Beyer, Baukje J van der Star, Reijerkerk, A, Huizinga, Ruth, Ummenthum, K., Gareth Pryce, Peferoen-Baert, R.M.B. (Regina), Valk, P. (Paul) van der, Wouter Gerritsen, Huizinga, R, Puentes, Fabiola, Huizinga, R. (Ruth), Beyer, C., Kipp, M, Gerritsen, W, Kipp, Markus, Beyer, C, Beyer, Cordian, Reijerkerk, A. (Arie), Kipp, M. (Markus), Pryce, G, Pryce, G., van der Valk, P., van der Valk, Paul   +70 more
core   +2 more sources

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

A preclinical mice model of multiple sclerosis based on the toxin-induced double-site demyelination of callosal and cerebellar fibers

Biological Research
Background Multiple sclerosis (MS) is an irreversible progressive CNS pathology characterized by the loss of myelin (i.e. demyelination). The lack of myelin is followed by a progressive neurodegeneration triggering symptoms as diverse as fatigue, motor ...
Sebastián Vejar, Ignacio S. Pizarro, Raúl Pulgar-Sepúlveda, Sinay C. Vicencio, Andrés Polit, Cristian A. Amador, Rodrigo del Rio, Rodrigo Varas, Juan A. Orellana, Fernando C. Ortiz   +9 more
doaj   +1 more source

What happens in the brain?

eLife, 2022
A new imaging method reveals previously undetected structural differences that may contribute to developmental language disorder.
Faye Smith, Timothy D Griffiths
doaj   +1 more source

The history of myelin [PDF]

Experimental Neurology, 2016
Andreas Vesalius is attributed the discovery of white matter in the 16th century but van Leeuwenhoek is arguably the first to have observed myelinated fibers in 1717. A globular myelin theory followed, claiming all elements of the nervous system except for Fontana's primitive cylinder with outer sheath in 1781. Remak's axon revolution in 1836 relegated
openaire   +2 more sources

Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse [PDF]

, 2012
Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Groh Janos, Dennis Klein, Spahn, Irene, Klein Dennis, Huber, M., Spahn, I., Ip, Chi Wang, Nave, Klaus-Armin, Diem Ricarda, Groh, J., Ip Chi Wang, Huber, Marianne, Sarah K. Williams, Rudolf Martini, Martini Rudolf, Kroner, A., Janos Groh, Ip, C., Williams, S., Edgar, Julia M., Kroner Antje, Huber Marianne, Ip, C.W., Martini, Rudolf, Nave Klaus-Armin, Martini, R., Antje Kroner, Chi Wang Ip, Diem, Ricarda, Edgar Julia M., Kroner, Antje, Julia M Edgar, Williams, Sarah K., Nave, K., Marianne Huber, Julia M. Edgar, Spahn Irene, Diem, R., Klaus-Armin Nave, Ricarda Diem, Sarah K Williams, Groh, Janos, Klein, Dennis, Klein, D., Edgar, J., Edgar, J.M., Williams Sarah K., Irene Spahn   +47 more
core   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source