Results 1 to 10 of about 5,711 (131)

The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases [PDF]

Brain Sciences, 2022
Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
John Matsoukas, Vasso Apostolopoulos, Christos T Chasapis   +2 more
exaly   +4 more sources

The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay [PDF]

Frontiers in Cellular Neuroscience, 2020
Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn, Kathrin Kusch, Ting Sun
exaly   +4 more sources

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice [PDF]

eLife, 2022
Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar.
Vasiliki-Ilya Gargareta, Josefine Reuschenbach, Sophie B Siems, Ting Sun, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus-Armin Nave, Olaf Jahn, Hauke B Werner   +12 more
doaj   +2 more sources

Proteome Profile of Myelin in the Zebrafish Brain

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Wiebke Möbius, Olaf Jahn, Tim Czopka
exaly   +3 more sources

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States. [PDF]

Glia
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
Baltar J, Abati R, Florido L, Holt MG.
europepmc   +2 more sources

Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea. [PDF]

Glia
Generation and analysis of an snRNA‐seq atlas of the hippocampus in POSA. Validation of reduced protein expression of six genes across four cell types. Cellular‐level investigation of aberrant glial function in POSA using transgenic reporter mice. ABSTRACT Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant
Williamson MR, Botas J, Hedayatpour MJ, Zlatkov T, Harmanci AS, Yates CJ, Nobleza K, Ailani R, Adler AC, Kheradmand F, Lee HK, Deneen B, Jeong HH, Chandrakantan A.   +13 more
europepmc   +2 more sources

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α-synuclein preformed fibrils-induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines. [PDF]

Brain Pathol
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Cartas-Cejudo P, De Miguel M, Extramiana L, Lachén-Montes M, Romero-Murillo S, Gveric D, Fernández-Irigoyen J, Santamaría E.   +7 more
europepmc   +2 more sources

Sex-specific changes in the hippocampal proteome of Negr1 −/− mice: insight into the mechanisms of neuropsychiatric disorders [PDF]

Biology of Sex Differences
Background Neuronal Growth Regulator 1 (NEGR1) is a cell adhesion molecule involved in hippocampal circuit development and function. Human genetic studies have identified NEGR1 variants as risk factors for a broad spectrum of neuropsychiatric disorders ...
Srirathi Muthuraman, Mohan Jayaram, Liisi Promet, Toomas Jagomäe, Arun Kumar Devarajan, Andreas-Christian Hade, Mari-Anne Philips, Katyayani Singh, Eero Vasar   +8 more
doaj   +2 more sources

AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model [PDF]

Journal of Neuroinflammation
Background A Proliferation-Inducing Ligand (APRIL) is a tumour necrosis factor superfamily member with multiple effector roles in the peripheral and central nervous system (CNS).
Leonardo Ricciardi, Federica Di Marco, Marion Decrop, Julia Di Stefano, Tejaswini Kakunuri, Joëlle van Rijswijk, Nicholas Vidas-Guscic, Yousra El Ouaamari, Alexandro A. Bufi, Ignace Van Spilbeeck, Johan Van Audekerke, Carole Faghel, Esther Bartholomeus, Eva Lion, Nathalie Cools, Steven Van Laere, Ilaria Cicalini, Vincenzo De Laurenzi, Una FitzGerald, Damiana Pieragostino, Bertrand Huard, Piero Del Boccio, Peter Ponsaerts, Marleen Verhoye   +23 more
doaj   +2 more sources

Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome [PDF]

Glia
Olaf Jahn, Patrizia Casaccia, Vinicius Daguano Gastaldi   +2 more
exaly   +2 more sources