Results 1 to 10 of about 5,503 (124)

The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases [PDF]

Brain Sciences, 2022
Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Christos T Chasapis, Konstantinos Kelaidonis, Harry Ridgway   +2 more
exaly   +4 more sources

The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay [PDF]

Frontiers in Cellular Neuroscience, 2020
Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn, Sophie B Siems, Kathrin Kusch   +2 more
exaly   +4 more sources

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice [PDF]

eLife, 2022
Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar.
Vasiliki-Ilya Gargareta, Josefine Reuschenbach, Sophie B Siems, Ting Sun, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus-Armin Nave, Olaf Jahn, Hauke B Werner   +12 more
doaj   +2 more sources

Proteome Profile of Myelin in the Zebrafish Brain

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B Siems, Olaf Jahn, Dorte Hesse
exaly   +3 more sources

Proteomic analysis of peripheral nerve myelin during murine aging

Frontiers in Cellular Neuroscience, 2023
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Joanna M Kirkpatrick, Helen Morrison, Cirri Emilio   +2 more
exaly   +3 more sources

Vagus Nerve Stimulation Paired With Tones Alters the Auditory Cortex Proteome in a Rat Model of Rett Syndrome. [PDF]

Dev Neurobiol
ABSTRACT Rett syndrome is a neurodevelopmental disorder caused by an X‐linked mutation of the MeCP2 gene. Individuals with Rett syndrome, as well as rodent models of this disorder, demonstrate abnormal cortical responses to sound, which impair auditory discrimination ability.
Myers IK, Bian F, Solano MP, Zoghby YE, Tavares-Ferreira D, Danaphongse T, Engineer CT.   +6 more
europepmc   +2 more sources

Sex-specific changes in the hippocampal proteome of Negr1 −/− mice: insight into the mechanisms of neuropsychiatric disorders [PDF]

Biology of Sex Differences
Background Neuronal Growth Regulator 1 (NEGR1) is a cell adhesion molecule involved in hippocampal circuit development and function. Human genetic studies have identified NEGR1 variants as risk factors for a broad spectrum of neuropsychiatric disorders ...
Srirathi Muthuraman, Mohan Jayaram, Liisi Promet, Toomas Jagomäe, Arun Kumar Devarajan, Andreas-Christian Hade, Mari-Anne Philips, Katyayani Singh, Eero Vasar   +8 more
doaj   +2 more sources

AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model [PDF]

Journal of Neuroinflammation
Background A Proliferation-Inducing Ligand (APRIL) is a tumour necrosis factor superfamily member with multiple effector roles in the peripheral and central nervous system (CNS).
Leonardo Ricciardi, Federica Di Marco, Marion Decrop, Julia Di Stefano, Tejaswini Kakunuri, Joëlle van Rijswijk, Nicholas Vidas-Guscic, Yousra El Ouaamari, Alexandro A. Bufi, Ignace Van Spilbeeck, Johan Van Audekerke, Carole Faghel, Esther Bartholomeus, Eva Lion, Nathalie Cools, Steven Van Laere, Ilaria Cicalini, Vincenzo De Laurenzi, Una FitzGerald, Damiana Pieragostino, Bertrand Huard, Piero Del Boccio, Peter Ponsaerts, Marleen Verhoye   +23 more
doaj   +2 more sources

The chaperonin TRiC component Cct3 is required for axonal transport, myelination, and neuromuscular junction refinement [PDF]

Cell Death and Disease
TRiCopathies are recently discovered neurodevelopmental diseases caused by pathogenic variants in components of the chaperonin tailless complex polypeptide 1 ring complex (TRiC).
Xiaomeng Zhang, Kamil Kajetan Zajt, Tayfun Palaz, Lisa Wang, Martin Groß, Florian Kraft, Joachim Weis, Juliane Bremer   +7 more
doaj   +2 more sources

Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome [PDF]

Glia
Sophie B Siems, Vasiliki-Ilya Gargareta, Leonie C Schadt   +2 more
exaly   +2 more sources