The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases [PDF]
Brain Sciences, 2022 Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
John Matsoukas +2 more
exaly +7 more sources
The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay [PDF]
Frontiers in Cellular Neuroscience, 2020 Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn, Kathrin Kusch, Ting Sun
exaly +9 more sources
Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice [PDF]
eLife, 2022 Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar.
Vasiliki-Ilya Gargareta +12 more
doaj +8 more sources
Proteome Profile of Myelin in the Zebrafish Brain [PDF]
Frontiers in Cell and Developmental Biology, 2021 The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Wiebke Möbius, Olaf Jahn, Tim Czopka
exaly +8 more sources
Proteomic analysis of peripheral nerve myelin during murine aging
Frontiers in Cellular Neuroscience, 2023 Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Joanna Kirkpatrick +2 more
exaly +5 more sources
Proteomic Characterization of Spinal Cord Myelin in the Mouse [PDF]
ASN NeuroThe myelin proteome is a critical structural and functional component of the central nervous system (CNS), undergoing dynamic remodeling throughout life. Pathological changes, such as those in multiple sclerosis, disrupt myelin integrity and lead to severe neurological deficits.
Markus Kipp +2 more
exaly +4 more sources
Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome [PDF]
GliaAbstractThe molecules that constitute myelin are critical for the integrity of axon/myelin‐units and thus speed and precision of impulse propagation. In the CNS, the protein composition of oligodendrocyte‐derived myelin has evolutionarily diverged and differs from that in the PNS.
Olaf Jahn +2 more
exaly +6 more sources
Sex-specific changes in the hippocampal proteome of Negr1 −/− mice: insight into the mechanisms of neuropsychiatric disorders [PDF]
Biology of Sex DifferencesBackground Neuronal Growth Regulator 1 (NEGR1) is a cell adhesion molecule involved in hippocampal circuit development and function. Human genetic studies have identified NEGR1 variants as risk factors for a broad spectrum of neuropsychiatric disorders ...
Srirathi Muthuraman +8 more
doaj +2 more sources
AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model [PDF]
Journal of NeuroinflammationBackground A Proliferation-Inducing Ligand (APRIL) is a tumour necrosis factor superfamily member with multiple effector roles in the peripheral and central nervous system (CNS).
Leonardo Ricciardi +23 more
doaj +2 more sources
The chaperonin TRiC component Cct3 is required for axonal transport, myelination, and neuromuscular junction refinement [PDF]
Cell Death and DiseaseTRiCopathies are recently discovered neurodevelopmental diseases caused by pathogenic variants in components of the chaperonin tailless complex polypeptide 1 ring complex (TRiC).
Xiaomeng Zhang +7 more
doaj +2 more sources