Results 1 to 10 of about 13,094 (201)

The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases [PDF]

Brain Sciences, 2022
Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Christos T. Chasapis, Konstantinos Kelaidonis, Harry Ridgway, Vasso Apostolopoulos, John M. Matsoukas   +4 more
doaj   +7 more sources

The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay [PDF]

Frontiers in Cellular Neuroscience, 2020
Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn, Sophie B. Siems, Kathrin Kusch, Dörte Hesse, Ramona B. Jung, Thomas Liepold, Marina Uecker, Ting Sun, Hauke B. Werner   +8 more
doaj   +9 more sources

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice [PDF]

eLife, 2022
Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar.
Vasiliki-Ilya Gargareta, Josefine Reuschenbach, Sophie B Siems, Ting Sun, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus-Armin Nave, Olaf Jahn, Hauke B Werner   +12 more
doaj   +8 more sources

Proteome Profile of Myelin in the Zebrafish Brain [PDF]

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Wiebke Möbius, Tim Czopka, Hauke B. Werner   +8 more
doaj   +8 more sources

CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment [PDF]

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline ...
Mihály Hajós, Kiran Pandey, Annabelle C. Singer, Duc Duong, Sara Bitarafan, Monika Shpokayte, Zach Malchano, Ralph Kern, James J. Lah, Allan I. Levey, Nicholas T. Seyfried   +10 more
doaj   +4 more sources

Proteomic analysis of peripheral nerve myelin during murine aging

Frontiers in Cellular Neuroscience, 2023
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Dario Lucas Helbing, Dario Lucas Helbing, Dario Lucas Helbing, Dario Lucas Helbing, Dario Lucas Helbing, Joanna M. Kirkpatrick, Michael Reuter, Julia Bischoff, Amy Stockdale, Annemarie Carlstedt, Emilio Cirri, Reinhard Bauer, Helen Morrison, Helen Morrison   +13 more
doaj   +4 more sources

Human Peripheral Myelin Protein 2 and Charcot-Marie-Tooth Disease or Structural Missense Variants Show Different Binding to Myelin-Like Lipid Monolayers. [PDF]

Chembiochem
We compare the membrane affinity of the P2 myelin protein and its Charcot–Marie–Tooth disease variants on a myelin‐like lipid monolayer. Epifluorescence microscopy reveals different two‐dimensional (2D) clustering and pressure‐dependent binding. Single‐point mutations in the P2 β‐barrel and α‐helix affect affinity.
Schöffmann FA, Imran MAS, Schwieger C, Hetland Ø, Jerschabek V, Raasakka A, Kursula P, Hinderberger D.   +7 more
europepmc   +2 more sources

The Ubiquitin Ligase Zinc Finger SWIM Domain-Containing Protein 8 Regulates Oligodendrocyte Development Through the Argonaute2/MicroRNA-7 Axis. [PDF]

Glia
ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Lei J, Zhong S, Fan R, Shu X, Wang G, Guo J, Xue S, Zheng L, Ren A, Ji J, Yang B, Duan S, Wang Z, Guo X.   +13 more
europepmc   +2 more sources

AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model [PDF]

Journal of Neuroinflammation
Background A Proliferation-Inducing Ligand (APRIL) is a tumour necrosis factor superfamily member with multiple effector roles in the peripheral and central nervous system (CNS).
Leonardo Ricciardi, Federica Di Marco, Marion Decrop, Julia Di Stefano, Tejaswini Kakunuri, Joëlle van Rijswijk, Nicholas Vidas-Guscic, Yousra El Ouaamari, Alexandro A. Bufi, Ignace Van Spilbeeck, Johan Van Audekerke, Carole Faghel, Esther Bartholomeus, Eva Lion, Nathalie Cools, Steven Van Laere, Ilaria Cicalini, Vincenzo De Laurenzi, Una FitzGerald, Damiana Pieragostino, Bertrand Huard, Piero Del Boccio, Peter Ponsaerts, Marleen Verhoye   +23 more
doaj   +2 more sources

The chaperonin TRiC component Cct3 is required for axonal transport, myelination, and neuromuscular junction refinement [PDF]

Cell Death and Disease
TRiCopathies are recently discovered neurodevelopmental diseases caused by pathogenic variants in components of the chaperonin tailless complex polypeptide 1 ring complex (TRiC).
Xiaomeng Zhang, Kamil Kajetan Zajt, Tayfun Palaz, Lisa Wang, Martin Groß, Florian Kraft, Joachim Weis, Juliane Bremer   +7 more
doaj   +2 more sources