Results 11 to 20 of about 5,574 (157)
Human myelin proteome and comparative analysis with mouse myelin [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2009 Myelin, formed by oligodendrocytes (OLs) in the CNS, is critical for axonal functions, and its damage leads to debilitating neurological disorders such as multiple sclerosis. Understanding the molecular mechanisms of myelination and the pathogenesis of human myelin disease has been limited partly by the relative lack of identification and functional ...
Bruce Trapp +2 more
exaly +5 more sources
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model
eLife, 2020 Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin.
Sophie B Siems +13 more
doaj +6 more sources
CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline ...
Mihály Hajós +10 more
doaj +3 more sources
Mitochondria in Myelinating Oligodendrocytes: Slow and Out of Breath?
Metabolites, 2021 Myelin is a lipid-rich membrane that wraps around axons and facilitates rapid action potential propagation. In the brain, myelin is synthesized and maintained by oligodendrocytes.
Niklas Meyer, Johanne Egge Rinholm
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The proteome of remyelination is different from that of developmental myelination [PDF]
, 2021 Abstract Loss of myelin underlies the pathology of several neurological disorders of diverse etiology. CNS remyelination by adult oligodendrocyte progenitor cells (OPCs) can occur but it differs from developmental myelination carried out by neonatal OPCs. We asked whether the myelin proteome of remyelinated regions is
Joana Paes de Faria +13 more
openaire +1 more source
Molecular Neurodegeneration, 2023 Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention ...
Jun Yup Lee +6 more
doaj +1 more source
Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage. [PDF]
PLoS ONE, 2009 The identification of new biomarkers is of high interest for the prediction of the disease course and also for the identification of pathomechanisms in multiple sclerosis (MS).
Ralf A Linker +9 more
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Study on Tissue Homogenization Buffer Composition for Brain Mass Spectrometry-Based Proteomics
Biomedicines, 2022 Mass spectrometry-based proteomics aims to study the proteome both qualitatively and quantitatively. A key step in proteomic analysis is sample preparation, which is crucial for reliable results.
Adam Aleksander Karpiński +7 more
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Biology, 2022 Proteomic analysis revealed the preservation of many proteins in the Heslington brain (which is at least 2600-year-old brain tissue uncovered within the skull excavated in 2008 from a pit in Heslington, Yorkshire, England).
Aaron S. Mohammed, Vladimir N. Uversky
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Neural Plasticity, 2023 Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary ...
Yuji Tsuchikawa +8 more
doaj +1 more source