Results 11 to 20 of about 5,726 (179)
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model [PDF]
eLife, 2020 Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin.
Sophie B Siems +13 more
doaj +7 more sources
CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline ...
Mihály Hajós +10 more
doaj +4 more sources
Proteomic Characterization of Spinal Cord Myelin in the Mouse [PDF]
ASN NeuroThe myelin proteome is a critical structural and functional component of the central nervous system (CNS), undergoing dynamic remodeling throughout life. Pathological changes, such as those in multiple sclerosis, disrupt myelin integrity and lead to severe neurological deficits.
Oliver Schmitt +2 more
exaly +4 more sources
Human myelin proteome and comparative analysis with mouse myelin [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2009 Myelin, formed by oligodendrocytes (OLs) in the CNS, is critical for axonal functions, and its damage leads to debilitating neurological disorders such as multiple sclerosis. Understanding the molecular mechanisms of myelination and the pathogenesis of human myelin disease has been limited partly by the relative lack of identification and functional ...
Akihiro Ishii +2 more
exaly +5 more sources
Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage. [PDF]
PLoS ONE, 2009 The identification of new biomarkers is of high interest for the prediction of the disease course and also for the identification of pathomechanisms in multiple sclerosis (MS).
Ralf A Linker +9 more
doaj +3 more sources
Myelin proteomics: the past, the unexpected and the future
Expert Review of Proteomics, 2014 Myelin proteomics has been the subject of intense research over the last decade, and its profiling has achieved good results by both in-gel and mass spectrometry-based techniques. 1280 proteins have been identified, a number expected to increase. Some of the identified proteins are as yet not established as true components of myelin.
I. Panfoli +6 more
openaire +4 more sources
An overview of the human brain myelin proteome and differences associated with schizophrenia
The World Journal of Biological Psychiatry, 2020 Disturbances in the myelin sheath drive disruptions in neural transmission and brain connectivity as seen in schizophrenia. Here, the myelin proteome was characterised in schizophrenia patients and healthy controls to visualise differences in proteomic profiles.A liquid chromatography tandem mass spectrometry-based shotgun proteomic analysis was ...
Daniel Martins-de-Souza +5 more
openaire +4 more sources
Partitioning the proteome: phase separation for targeted analysis of membrane proteins in human post-mortem brain. [PDF]
PLoS ONE, 2012 Neuroproteomics is a powerful platform for targeted and hypothesis driven research, providing comprehensive insights into cellular and sub-cellular disease states, Gene × Environmental effects, and cellular response to medication effects in human, animal,
Jane A English +4 more
doaj +3 more sources
Molecular Neurodegeneration, 2023 Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention ...
Jun Yup Lee +6 more
doaj +2 more sources
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain [PDF]
Journal of Neuroinflammation, 2012 Background The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath.
Liu Huaqing +9 more
doaj +3 more sources