Proteomic analysis of peripheral nerve myelin during murine aging [PDF]
Frontiers in Cellular Neuroscience, 2023 Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Dario Lucas Helbing +13 more
doaj +5 more sources
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model [PDF]
eLife, 2020 Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin.
Sophie B Siems +13 more
doaj +7 more sources
Proteomic Characterization of Spinal Cord Myelin in the Mouse [PDF]
ASN NeuroThe myelin proteome is a critical structural and functional component of the central nervous system (CNS), undergoing dynamic remodeling throughout life. Pathological changes, such as those in multiple sclerosis, disrupt myelin integrity and lead to severe neurological deficits.
Markus Kipp +2 more
exaly +4 more sources
CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline ...
Mihály Hajós +10 more
doaj +3 more sources
Myelin basic protein peptide 45–89 induces the release of nitric oxide from microglial cells. [PDF]
, 2002 Continuous (24 h) exposure of mixed oligodendrocyte/microglial cells to peptides 45–89 derived from citrullinated C8 isoforms of myelin basic protein (MBP) induces cell death.
Pichkhadze, B. +4 more
core +7 more sources
Mitochondria in Myelinating Oligodendrocytes: Slow and Out of Breath?
Metabolites, 2021 Myelin is a lipid-rich membrane that wraps around axons and facilitates rapid action potential propagation. In the brain, myelin is synthesized and maintained by oligodendrocytes.
Niklas Meyer, Johanne Egge Rinholm
doaj +1 more source
The proteome of remyelination is different from that of developmental myelination [PDF]
, 2021 Abstract Loss of myelin underlies the pathology of several neurological disorders of diverse etiology. CNS remyelination by adult oligodendrocyte progenitor cells (OPCs) can occur but it differs from developmental myelination carried out by neonatal OPCs. We asked whether the myelin proteome of remyelinated regions is
Joana Paes de Faria +13 more
openaire +1 more source
Molecular Neurodegeneration, 2023 Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention ...
Jun Yup Lee +6 more
doaj +1 more source
Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage. [PDF]
PLoS ONE, 2009 The identification of new biomarkers is of high interest for the prediction of the disease course and also for the identification of pathomechanisms in multiple sclerosis (MS).
Ralf A Linker +9 more
doaj +1 more source
Study on Tissue Homogenization Buffer Composition for Brain Mass Spectrometry-Based Proteomics
Biomedicines, 2022 Mass spectrometry-based proteomics aims to study the proteome both qualitatively and quantitatively. A key step in proteomic analysis is sample preparation, which is crucial for reliable results.
Adam Aleksander Karpiński +7 more
doaj +1 more source