Myelin proteomics: the past, the unexpected and the future.
Expert Review of Proteomics, 2014 Myelin proteomics has been the subject of intense research over the last decade, and its profiling has achieved good results by both in-gel and mass spectrometry-based techniques. 1280 proteins have been identified, a number expected to increase. Some of
I. Panfoli +6 more
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An overview of the human brain myelin proteome and differences associated with schizophrenia
The World Journal of Biological Psychiatry, 2020 Objectives Disturbances in the myelin sheath drive disruptions in neural transmission and brain connectivity as seen in schizophrenia. Here, the myelin proteome was characterised in schizophrenia patients and healthy controls to visualise differences in ...
Reis-de-Oliveira, G. +10 more
core +4 more sources
CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline ...
Mihály Hajós +10 more
doaj +3 more sources
The proteome of remyelination is different from that of developmental myelination [PDF]
, 2021 Abstract Loss of myelin underlies the pathology of several neurological disorders of diverse etiology. CNS remyelination by adult oligodendrocyte progenitor cells (OPCs) can occur but it differs from developmental myelination carried out by neonatal OPCs. We asked whether the myelin proteome of remyelinated regions is
Joana Paes de Faria +13 more
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Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea. [PDF]
GliaGeneration and analysis of an snRNA‐seq atlas of the hippocampus in POSA. Validation of reduced protein expression of six genes across four cell types. Cellular‐level investigation of aberrant glial function in POSA using transgenic reporter mice. ABSTRACT Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant
Williamson MR +13 more
europepmc +2 more sources
Myelin basic protein peptide 45–89 induces the release of nitric oxide from microglial cells. [PDF]
, 2002 Continuous (24 h) exposure of mixed oligodendrocyte/microglial cells to peptides 45–89 derived from citrullinated C8 isoforms of myelin basic protein (MBP) induces cell death.
Pichkhadze, B. +4 more
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Molecular Neurodegeneration, 2023 Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention ...
Jun Yup Lee +6 more
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Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage. [PDF]
PLoS ONE, 2009 The identification of new biomarkers is of high interest for the prediction of the disease course and also for the identification of pathomechanisms in multiple sclerosis (MS).
Ralf A Linker +9 more
doaj +1 more source
Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States. [PDF]
GliaProximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
Baltar J, Abati R, Florido L, Holt MG.
europepmc +2 more sources
Study on Tissue Homogenization Buffer Composition for Brain Mass Spectrometry-Based Proteomics
Biomedicines, 2022 Mass spectrometry-based proteomics aims to study the proteome both qualitatively and quantitatively. A key step in proteomic analysis is sample preparation, which is crucial for reliable results.
Adam Aleksander Karpiński +7 more
doaj +1 more source