Biology, 2022 Proteomic analysis revealed the preservation of many proteins in the Heslington brain (which is at least 2600-year-old brain tissue uncovered within the skull excavated in 2008 from a pit in Heslington, Yorkshire, England).
Aaron S. Mohammed, Vladimir N. Uversky
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Neural Plasticity, 2023 Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary ...
Yuji Tsuchikawa +8 more
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Differential expression and MAL-dependent targeting of the L-MAG and S-MAG isoforms to myelin membranes [PDF]
, 2003 Many degenerative diseases of the nervous system, including Multiple Sclerosis and peripheral neuropathies, are triggered by an impaired interaction between the axons and their surrounding myelin sheaths.
Erb, Michael
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Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics
Cells, 2023 Myelin basic protein (MBP) is one of the key structural elements of the myelin sheath and has autoantigenic properties in multiple sclerosis (MS). Its intracellular interaction network is still partially deconvoluted due to the unfolded structure, abnormally basic charge, and specific cellular localization.
Evgeniya V. Smirnova +6 more
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Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis. [PDF]
PLoS ONE, 2016 BACKGROUND:Epstein-Barr virus (EBV) infection represents a major environmental risk factor for multiple sclerosis (MS), with evidence of selective expansion of Epstein-Barr Nuclear Antigen-1 (EBNA1)-specific CD4+ T cells that cross-recognize MS ...
Monika Tschochner +11 more
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Proteomic mapping provides powerful insights into functional myelin biology [PDF]
Proceedings of the National Academy of Sciences, 2004 Myelin is a dynamic, functionally active membrane necessary for rapid action potential conduction, axon survival, and cytoarchitecture. The number of debilitating neurological disorders that occur when myelin is disrupted emphasizes its importance. Using high-resolution 2D gel electrophoresis, mass spectrometry, and immunoblotting, we have developed an
Christopher M, Taylor +6 more
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Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5
eLife, 2022 Oligodendrocytes facilitate rapid impulse propagation along the axons they myelinate and support their long-term integrity. However, the functional relevance of many myelin proteins has remained unknown.
Tobias J Buscham +16 more
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Partitioning the proteome: phase separation for targeted analysis of membrane proteins in human post-mortem brain. [PDF]
PLoS ONE, 2012 Neuroproteomics is a powerful platform for targeted and hypothesis driven research, providing comprehensive insights into cellular and sub-cellular disease states, Gene × Environmental effects, and cellular response to medication effects in human, animal,
Jane A English +4 more
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Functional role of the overexpression of the myelin and lymphocyte protein MAL in Schwann cells [PDF]
, 2013 For fast propagation of action potentials in the nervous system, higher vertebrates have developed a specialized plasma membrane structure, the myelin, ensheathing nerve fibers. Myelin sheaths are formed by Schwann cells in the peripheral nervous system (
Schmid, Daniela
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Particular aspects of myelin-axon interactions in health and disease : the expression of myelin-associated glycoprotein isoforms in CNS and PNS. Early axonal pathology in the dysmyelinating peripheral neuropathy CMT1A [PDF]
, 2007 An intact myelin sheath is crucial for the rapid propagation of action potentials along myelinated axons. There are many neurodegenerative diseases associated with defect myelin sheaths resulting in severe clinical symptoms such as multiple sclerosis ...
Flück, Bettina
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