Results 31 to 40 of about 5,726 (179)

Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis. [PDF]

PLoS ONE, 2016
BACKGROUND:Epstein-Barr virus (EBV) infection represents a major environmental risk factor for multiple sclerosis (MS), with evidence of selective expansion of Epstein-Barr Nuclear Antigen-1 (EBNA1)-specific CD4+ T cells that cross-recognize MS ...
Monika Tschochner, Shay Leary, Don Cooper, Kaija Strautins, Abha Chopra, Hayley Clark, Linda Choo, David Dunn, Ian James, William M Carroll, Allan G Kermode, David Nolan   +11 more
doaj   +1 more source

Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5

eLife, 2022
Oligodendrocytes facilitate rapid impulse propagation along the axons they myelinate and support their long-term integrity. However, the functional relevance of many myelin proteins has remained unknown.
Tobias J Buscham, Maria A Eichel-Vogel, Anna M Steyer, Olaf Jahn, Nicola Strenzke, Rakshit Dardawal, Tor R Memhave, Sophie B Siems, Christina Müller, Martin Meschkat, Ting Sun, Torben Ruhwedel, Wiebke Möbius, Eva-Maria Krämer-Albers, Susann Boretius, Klaus-Armin Nave, Hauke B Werner   +16 more
doaj   +1 more source

Data_Sheet_1_Proteomic analysis of peripheral nerve myelin during murine aging.docx

, 2023
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Helen Morrison (781686), Reinhard Bauer (437078), Joanna M. Kirkpatrick (13111769), Michael Reuter (268288), Julia Bischoff (17301412), Annemarie Carlstedt (5390936), Emilio Cirri (1386072), Amy Stockdale (17301415), Dario Lucas Helbing (17301409)   +8 more
core   +1 more source

Membrane Protein Identification in Rodent Brain Tissue Samples and Acute Brain Slices

Cells, 2019
Acute brain slices are a sample format for electrophysiology, disease modeling, and organotypic cultures. Proteome analyses based on mass spectrometric measurements are seldom used on acute slices, although they offer high-content protein analyses and ...
Sarah Joost, Stefan Mikkat, Michael Wille, Antje Schümann, Oliver Schmitt   +4 more
doaj   +1 more source

Global profiling of the proteome, phosphoproteome, and N-glycoproteome of protoscoleces and adult worms of Echinococcus granulosus

Frontiers in Veterinary Science, 2023
IntroductionCystic echinococcosis (CE) is a chronic zoonosis caused by infection with the metacestode of the Echinococcus granulosus. A unique characteristic of E.
Zhengrong Wang, Zhengrong Wang, Xinyue Jia, Xinyue Jia, Xinyue Jia, Jing Ma, Jing Ma, Jing Ma, Yanyan Zhang, Yanyan Zhang, Yan Sun, Yan Sun, Xinwen Bo, Xinwen Bo, Xinwen Bo   +14 more
doaj   +1 more source

Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

World Journal of Pediatrics, 2022
Abstract Background Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an autoimmune demyelinating disorder of the central nervous system. Methods Extracted proteins from 34 cerebrospinal fluid (CSF) samples [patients with MOGAD (MOG group, n ...
Wang, Yi-Long, Zhu, Meng-Ying, Yuan, Zhe-Feng, Ren, Xiao-Yan, Guo, Xiao-Tong, Hua, Yi, Xu, Lu, Zhao, Cong-Ying, Jiang, Li-Hua, Zhang, Xin, Sheng, Guo-Xia, Jiang, Pei-Fang, Zhao, Zheng-Yan, Gao, Feng   +13 more
openaire   +2 more sources

Neurodevelopmental Impact of Prenatal Stress: A Proteomic Analysis of Myelination Disruptions in the Avian Embryo. [PDF]

Dev Neurobiol
ABSTRACT Prenatal stress, mediated by elevated glucocorticoid (GC) levels, is a relevant modulator of fetal brain development and a known risk factor for neurodevelopmental disorders. Using the avian embryo as a vertebrate model, we injected corticosterone into the yolk on embryonic day 6 (E6) and assessed neurodevelopmental outcomes ...
Gaertner B, Morosan-Puopolo G, Brand-Saberi B, Schücke C, Saberi D, Klöster K, Faissner S, Marcus K, Gellisch M, Eggers B.   +9 more
europepmc   +4 more sources

Protein expression profiling in rat hippocampus after focal cerebral ischemia injury [PDF]

Journal of Integrative Neuroscience, 2018
The aim in this study was to explore protein expression profiles in the rat hippocampus after induction of focal ischemia injury. Forty male Sprague Dawley rats were randomly divided into four equal groups after ischemia injury surgery: Control, Day 3 ...
Lichan He, Rui He, Ruihua Liang, Yi Li, Xiaoqiang Li, Chuqiao Li, Suping Zhang
doaj   +1 more source

Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function

Cells, 2023
Thyroid hormone (TH) transporter MCT8 deficiency causes severe locomotor disabilities likely due to insufficient TH transport across brain barriers and, consequently, compromised neural TH action.
Devon Siemes, Pieter Vancamp, Boyka Markova, Philippa Spangenberg, Olga Shevchuk, Bente Siebels, Hartmut Schlüter, Steffen Mayerl, Heike Heuer, Daniel Robert Engel   +9 more
doaj   +1 more source

The transcriptome of mouse central nervous system myelin [PDF]

, 2016
Rapid nerve conduction in the CNS is facilitated by insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body.
Garding, Angela, Garding, A., Jung, Ramona B., Goebbels, S., White, Robin, Goebbels, Sandra, Werner, H., Tiwari, Vijay K., Jung, R., Thakurela, S., Müller, C., Müller, Christina, Tiwari, V., Thakurela, Sudhir, Werner, Hauke B., White, R.   +15 more
core   +1 more source