Results 41 to 50 of about 5,726 (179)

Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s disease

Acta Neuropathologica Communications, 2018
Although the genetic causes for several rare, familial forms of Alzheimer’s disease (AD) have been identified, the etiology of the sporadic form of AD remains unclear.
Qi Zhang, Cheng Ma, Marla Gearing, Peng George Wang, Lih-Shen Chin, Lian Li   +5 more
doaj   +1 more source

Myelin-axon interface vulnerability in Alzheimer's disease revealed by subcellular proteomics and imaging of human and mouse brain. [PDF]

Nat Neurosci
Myelin ensheathment is essential for rapid axonal conduction, metabolic support and neuronal plasticity. In Alzheimer's disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. We implemented proximity labeling subcellular proteomics of the myelin-axon interface in postmortem human brains from ...
Cai Y, Pinheiro-de-Sousa I, Slobodyanyuk M, Chen F, Huynh T, Kanyo J, Tang P, Fuentes LA, Braker A, Welch R, Huttner A, Tong L, Yuan P, Lam TT, Petsalaki E, Reimand J, Nairn AC, Grutzendler J.   +17 more
europepmc   +3 more sources

Proteomic analysis of nuclear factors binding to an intronic enhancer in the myelin proteolipid protein gene [PDF]

Journal of Neurochemistry, 2008
AbstractThe myelin proteolipid protein gene (Plp1) encodes the most abundant protein found in CNS myelin, accounting for nearly one‐half of the total protein. Its expression in oligodendrocytes is developmentally regulated – peaking during the active myelination period of CNS development. Previously, we have identified a novel enhancer (designated ASE)
Anna, Dobretsova, Jennifer W, Johnson, Richard C, Jones, Ricky D, Edmondson, Patricia A, Wight   +4 more
openaire   +2 more sources

Proteome and lipidome of myelin

, 2023
Proteom i lipidom mijelina središnjeg i perifernog živčanog sustava velikim su dijelom jednaki u svome sastavu. Proteomi se razlikuju u najzastupljenijem proteinu (proteolipidni protein u središnjem živčanom sustavu i protein nula u perifernom živčanom
Pirić, Ana
core   +1 more source

Combined transcriptomic and proteomic analyses reveal relevant myelin features in mice with ischemic stroke. [PDF]

Funct Integr Genomics
Ischemic stroke (IS), a leading cause of global disability and mortality, is characterized by white matter damage and demyelination. Despite advances, the molecular mechanisms driving post-IS myelin pathology remain poorly understood, limiting therapeutic development. This study investigates key myelin-related genes (MRGs) and their regulatory networks
Qian Q, Lyu H, Wang W, Wang Q, Li D, Liu X, He Y, Shen M.   +7 more
europepmc   +3 more sources

Discovery of prognostic biomarker candidates of lacunar infarction by quantitative proteomics of microvesicles enriched plasma. [PDF]

PLoS ONE, 2014
Lacunar infarction (LACI) is a subtype of acute ischemic stroke affecting around 25% of all ischemic stroke cases. Despite having an excellent recovery during acute phase, certain LACI patients have poor mid- to long-term prognosis due to the recurrence ...
Arnab Datta, Christopher P Chen, Siu Kwan Sze   +2 more
doaj   +1 more source

Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice

eLife, 2022
The age and sex of studied animals profoundly impact experimental outcomes in biomedical research. However, most preclinical studies in mice use a wide-spanning age range from 4 to 20 weeks and do not assess male and female mice in parallel.
Feng Xian, Julia Regina Sondermann, David Gomez Varela, Manuela Schmidt   +3 more
doaj   +1 more source

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

Proteomic analysis of phosphoproteins and its application to myelin basic proteins.

SEIBUTSU BUTSURI KAGAKU, 2005
従来タンパク質のリン酸化は, ラジオアイソトープ標識法やウエスタンブロット法を用いて研究されてきたが, 我々は質量分析法による高感度分析法の有効性について基礎的な検討を行った. まずリン酸化部位が既知の標準ペプチドやカゼインを用いて, Post-source decay モードによるMALDI-TOF質量分析を行い, セリンおよびトレオニンリン酸化ペプチド検出における有効性を確認した. しかしチロシンリン酸化ペプチドには, 必ずしも有効ではないこともわかった. 検出感度を上げるために, 市販のリン酸化ペプチドおよびリン酸化タンパク質濃縮キットの使用方法の最適化を行い, 有効性を確認した. さらに我々はこの方法をラットミエリンのミエリン塩基性タンパク質の分析に応用し, リン酸化ペプチドの高感度検出と,
Akiyama, Kyoichi, Shimada, Nobuko, Kimura, Narimichi, Toda, Tosifusa   +3 more
openaire   +2 more sources

Proteomics‐level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease [PDF]

Journal of Neurochemistry, 2015
AbstractVanishing white matter (VWM) is a recessive neurodegenerative disease caused by mutations in translation initiation factor eIF2B and leading to progressive brain myelin deterioration, secondary axonal damage, and death in early adolescence. Eif2b5R132H/R132H mice exhibit delayed developmental myelination, mild early neurodegeneration and a ...
Irit, Gat-Viks, Tamar, Geiger, Mali, Barbi, Gali, Raini, Orna, Elroy-Stein   +4 more
openaire   +2 more sources