Results 41 to 50 of about 132,321 (210)

Proteomic analysis of nuclear factors binding to an intronic enhancer in the myelin proteolipid protein gene [PDF]

Journal of Neurochemistry, 2008
AbstractThe myelin proteolipid protein gene (Plp1) encodes the most abundant protein found in CNS myelin, accounting for nearly one‐half of the total protein. Its expression in oligodendrocytes is developmentally regulated – peaking during the active myelination period of CNS development. Previously, we have identified a novel enhancer (designated ASE)
Anna, Dobretsova, Jennifer W, Johnson, Richard C, Jones, Ricky D, Edmondson, Patricia A, Wight   +4 more
openaire   +2 more sources

Immunodominant fragments of myelin basic protein initiate T cell-dependent pain

Journal of Neuroinflammation, 2012
Background The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath.
Liu Huaqing, Shiryaev Sergey A, Chernov Andrei V, Kim Youngsoon, Shubayev Igor, Remacle Albert G, Baranovskaya Svetlana, Golubkov Vladislav S, Strongin Alex Y, Shubayev Veronica I   +9 more
doaj   +1 more source

Discovery of prognostic biomarker candidates of lacunar infarction by quantitative proteomics of microvesicles enriched plasma. [PDF]

PLoS ONE, 2014
Lacunar infarction (LACI) is a subtype of acute ischemic stroke affecting around 25% of all ischemic stroke cases. Despite having an excellent recovery during acute phase, certain LACI patients have poor mid- to long-term prognosis due to the recurrence ...
Arnab Datta, Christopher P Chen, Siu Kwan Sze   +2 more
doaj   +1 more source

Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice

eLife, 2022
The age and sex of studied animals profoundly impact experimental outcomes in biomedical research. However, most preclinical studies in mice use a wide-spanning age range from 4 to 20 weeks and do not assess male and female mice in parallel.
Feng Xian, Julia Regina Sondermann, David Gomez Varela, Manuela Schmidt   +3 more
doaj   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Proteomic analysis of phosphoproteins and its application to myelin basic proteins.

SEIBUTSU BUTSURI KAGAKU, 2005
従来タンパク質のリン酸化は, ラジオアイソトープ標識法やウエスタンブロット法を用いて研究されてきたが, 我々は質量分析法による高感度分析法の有効性について基礎的な検討を行った. まずリン酸化部位が既知の標準ペプチドやカゼインを用いて, Post-source decay モードによるMALDI-TOF質量分析を行い, セリンおよびトレオニンリン酸化ペプチド検出における有効性を確認した. しかしチロシンリン酸化ペプチドには, 必ずしも有効ではないこともわかった. 検出感度を上げるために, 市販のリン酸化ペプチドおよびリン酸化タンパク質濃縮キットの使用方法の最適化を行い, 有効性を確認した. さらに我々はこの方法をラットミエリンのミエリン塩基性タンパク質の分析に応用し, リン酸化ペプチドの高感度検出と,
Akiyama, Kyoichi, Shimada, Nobuko, Kimura, Narimichi, Toda, Tosifusa   +3 more
openaire   +2 more sources

Proteomics‐level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease [PDF]

Journal of Neurochemistry, 2015
AbstractVanishing white matter (VWM) is a recessive neurodegenerative disease caused by mutations in translation initiation factor eIF2B and leading to progressive brain myelin deterioration, secondary axonal damage, and death in early adolescence. Eif2b5R132H/R132H mice exhibit delayed developmental myelination, mild early neurodegeneration and a ...
Irit, Gat-Viks, Tamar, Geiger, Mali, Barbi, Gali, Raini, Orna, Elroy-Stein   +4 more
openaire   +2 more sources

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Particular aspects of myelin-axon interactions in health and disease : the expression of myelin-associated glycoprotein isoforms in CNS and PNS. Early axonal pathology in the dysmyelinating peripheral neuropathy CMT1A [PDF]

, 2007
An intact myelin sheath is crucial for the rapid propagation of action potentials along myelinated axons. There are many neurodegenerative diseases associated with defect myelin sheaths resulting in severe clinical symptoms such as multiple sclerosis ...
Flück, Bettina
core   +1 more source

Shaping Membrane Interfaces in Lipid Vesicles Mimicking the Cytoplasmic Leaflet of Myelin through Variation of Cholesterol and Myelin Basic Protein Contents [PDF]

, 2022
Myelin basic protein (MBP) is an intrinsically disordered protein and in the central nervous system (CNS) mainly responsible for connecting the cytoplasmic surfaces of the multilamellar, compact myelin.
Annette, Meister, George, Harauz, Dariush, Hinderberger, Jennica, Träger, Gerd, Hause   +4 more
core   +2 more sources