Results 41 to 50 of about 124,147 (190)

Immunodominant fragments of myelin basic protein initiate T cell-dependent pain

Journal of Neuroinflammation, 2012
Background The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath.
Liu Huaqing, Shiryaev Sergey A, Chernov Andrei V, Kim Youngsoon, Shubayev Igor, Remacle Albert G, Baranovskaya Svetlana, Golubkov Vladislav S, Strongin Alex Y, Shubayev Veronica I   +9 more
doaj   +1 more source

Discovery of prognostic biomarker candidates of lacunar infarction by quantitative proteomics of microvesicles enriched plasma. [PDF]

PLoS ONE, 2014
Lacunar infarction (LACI) is a subtype of acute ischemic stroke affecting around 25% of all ischemic stroke cases. Despite having an excellent recovery during acute phase, certain LACI patients have poor mid- to long-term prognosis due to the recurrence ...
Arnab Datta, Christopher P Chen, Siu Kwan Sze   +2 more
doaj   +1 more source

Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice

eLife, 2022
The age and sex of studied animals profoundly impact experimental outcomes in biomedical research. However, most preclinical studies in mice use a wide-spanning age range from 4 to 20 weeks and do not assess male and female mice in parallel.
Feng Xian, Julia Regina Sondermann, David Gomez Varela, Manuela Schmidt   +3 more
doaj   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Synthesis of antagonists of Myelin-associated glycoprotein (MAG) for conformational and SAR studies [PDF]

, 2004
Damage to the central nervous system (CNS) of higher vertebrates, including humans, often results in devastating and persistent functional deficits.
Gao, Gan-Pan
core   +1 more source

Proteomic analysis of phosphoproteins and its application to myelin basic proteins.

SEIBUTSU BUTSURI KAGAKU, 2005
従来タンパク質のリン酸化は, ラジオアイソトープ標識法やウエスタンブロット法を用いて研究されてきたが, 我々は質量分析法による高感度分析法の有効性について基礎的な検討を行った. まずリン酸化部位が既知の標準ペプチドやカゼインを用いて, Post-source decay モードによるMALDI-TOF質量分析を行い, セリンおよびトレオニンリン酸化ペプチド検出における有効性を確認した. しかしチロシンリン酸化ペプチドには, 必ずしも有効ではないこともわかった. 検出感度を上げるために, 市販のリン酸化ペプチドおよびリン酸化タンパク質濃縮キットの使用方法の最適化を行い, 有効性を確認した. さらに我々はこの方法をラットミエリンのミエリン塩基性タンパク質の分析に応用し, リン酸化ペプチドの高感度検出と,
Akiyama, Kyoichi, Shimada, Nobuko, Kimura, Narimichi, Toda, Tosifusa   +3 more
openaire   +2 more sources

Proteomics‐level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease [PDF]

Journal of Neurochemistry, 2015
AbstractVanishing white matter (VWM) is a recessive neurodegenerative disease caused by mutations in translation initiation factor eIF2B and leading to progressive brain myelin deterioration, secondary axonal damage, and death in early adolescence. Eif2b5R132H/R132H mice exhibit delayed developmental myelination, mild early neurodegeneration and a ...
Irit, Gat-Viks, Tamar, Geiger, Mali, Barbi, Gali, Raini, Orna, Elroy-Stein   +4 more
openaire   +2 more sources

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

eLife, 2019
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2B ...
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski   +21 more
doaj   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source