Results 61 to 70 of about 5,726 (179)

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Secreted Amyloid Precursor Protein Alpha (sAPPα) Regulates the Cellular Proteome and Secretome of Mouse Primary Astrocytes

, 2023
Secreted amyloid precursor protein alpha (sAPPα), processed from a parent mammalian brain protein, amyloid precursor protein, can modulate learning and memory.
Torsten Kleffmann, Katie Peppercorn, Warren P. Tate, Stephanie M. Hughes   +3 more
core   +1 more source

Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells

The FEBS Journal, EarlyView.
D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono, Yuji Shishido, Toshiyuki Yamagishi, Kiyoshi Fukui   +3 more
wiley   +1 more source

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

Фармакоэкономика
Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect on ...
O. A. Gromova, I. Yu. Torshin, A. G. Moiseenok   +2 more
doaj   +1 more source

Age-dependent transcriptome and proteome following transection of neonatal spinal cord of Monodelphis domestica (South American grey short-tailed opossum). [PDF]

PLoS ONE, 2014
This study describes a combined transcriptome and proteome analysis of Monodelphis domestica response to spinal cord injury at two different postnatal ages.
Norman R Saunders, Natassya M Noor, Katarzyna M Dziegielewska, Benjamin J Wheaton, Shane A Liddelow, David L Steer, C Joakim Ek, Mark D Habgood, Matthew J Wakefield, Helen Lindsay, Jessie Truettner, Robert D Miller, A Ian Smith, W Dalton Dietrich   +13 more
doaj   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Unveiling alterative splice diversity from human oligodendrocyte proteome data

, 2017
Oligodendrocytes produce and maintain the myelin sheath of axons in the central nervous system. Because misassembled myelin sheaths have been associated with brain disorders such as multiple sclerosis and schizophrenia, recent advances have been made ...
Wajnberg, Gabriel, Cassoli, Juliana S., Pauletti, Bianca Alves, Tavares, Raphael, Leme, Adriana Franco Paes, Scherer, Nicole de Miranda, Passetti, Fabio, Souza, Daniel Martins de, Ferreira, Carlos Gil, Souza, Patricia Savio de Araujo   +9 more
core   +2 more sources

A Systematic Review of Tissue and Single Cell Transcriptome/Proteome Studies of the Brain in Multiple Sclerosis

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system (CNS). Although inflammatory responses are efficiently treated, therapies for progression are scarce and suboptimal, and biomarkers to predict
Maria L. Elkjaer, Maria L. Elkjaer, Maria L. Elkjaer, Richard Röttger, Jan Baumbach, Zsolt Illes, Zsolt Illes, Zsolt Illes   +7 more
doaj   +1 more source

Immune dysregulation in mania: A proof‐of‐concept platelet proteomics study

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data‐driven, unbiased approach to uncover biological alterations.
Paola Magioncalda, Matteo Martino, Nhi Thao Ngoc Le, Wen‐Yin Chen, Ming‐Chyi Huang, David Blum, Thierry Burnouf   +6 more
wiley   +1 more source

Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing.

, 2020
Following central nervous system (CNS) demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination.
Fitzgerald, Denise C; id_orcid, Cubillos, Juan F, McMurran, Christopher E, de la Fuente, Alerie G, Bergles, Dwight E, Franklin, Robin J M, Ghosh, Tanay, Jones, Clare A, Lilley, Kathryn S, Glover, Colin P, Queiroz, Rayner M L   +10 more
core   +1 more source