Results 61 to 70 of about 132,321 (210)

Proteomics analysis of periplaque and chronic inactive multiple sclerosis lesions

Frontiers in Molecular Neuroscience
BackgroundMultiple sclerosis (MS) is a demyelinating disease of the central nervous system characterized by increased inflammation and immune responses, oxidative injury, mitochondrial dysfunction, and iron dyshomeostasis leading to demyelination and ...
Jordan M. Wilkins, Kiran K. Mangalaparthi, Brian C. Netzel, William A. Sherman, Yong Guo, Alicja Kalinowska-Lyszczarz, Akhilesh Pandey, Claudia F. Lucchinetti   +7 more
doaj   +1 more source

Specific peptide enrichment strategies for neuropsychiatric disorders: From material design to diagnostic applications

Interdisciplinary Medicine, EarlyView.
This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang, Yejiao Shi, Minghui Guo, Yang Huang, Yirong Wang, Leping Huang, Helena S. Azevedo, Honggang Hu, Xin Dong   +8 more
wiley   +1 more source

The evolution of the plant organellar proteome [PDF]

, 2022
A hallmark of eukaryotic cells is the compartmentalisation of intracellular processes into specialised, membrane-bound compartments known as organelles. The function of organelles is dependent on a suite of proteins localised within them (the organellar ...
Costello, Rona Moira Oonagh
core   +1 more source

Metabolomic insights for the authentication and traceability of antibiotic‐free pork: a pilot study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Antibiotic‐free production within the meat supply chain is a source of concern since new voluntary label claims need to be authenticated to prevent fraud. Therefore, an untargeted 1H NMR‐based metabolomics approach coupled to unsupervised (principal component analysis) and supervised (orthogonal partial least squares discriminant ...
Maria Olga Varrà, Maria Pia Fabrile, Sergio Ghidini, Augusta Caligiani, Federico Scali, Veronica Lolli, Giovanni Loris Alborali, Adriana Ianieri, Emanuela Zanardi   +8 more
wiley   +1 more source

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

Фармакоэкономика
Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect on ...
O. A. Gromova, I. Yu. Torshin, A. G. Moiseenok   +2 more
doaj   +1 more source

Age-dependent transcriptome and proteome following transection of neonatal spinal cord of Monodelphis domestica (South American grey short-tailed opossum). [PDF]

PLoS ONE, 2014
This study describes a combined transcriptome and proteome analysis of Monodelphis domestica response to spinal cord injury at two different postnatal ages.
Norman R Saunders, Natassya M Noor, Katarzyna M Dziegielewska, Benjamin J Wheaton, Shane A Liddelow, David L Steer, C Joakim Ek, Mark D Habgood, Matthew J Wakefield, Helen Lindsay, Jessie Truettner, Robert D Miller, A Ian Smith, W Dalton Dietrich   +13 more
doaj   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

A Systematic Review of Tissue and Single Cell Transcriptome/Proteome Studies of the Brain in Multiple Sclerosis

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system (CNS). Although inflammatory responses are efficiently treated, therapies for progression are scarce and suboptimal, and biomarkers to predict
Maria L. Elkjaer, Maria L. Elkjaer, Maria L. Elkjaer, Richard Röttger, Jan Baumbach, Zsolt Illes, Zsolt Illes, Zsolt Illes   +7 more
doaj   +1 more source

Mass Spectrometry Imaging–Guided Proteomics, an Emerging Frontier in Spatial Biology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Spatial heterogeneity is a defining feature of tissue organization, yet conventional proteomic analysis provides limited information about the spatial origins of identified proteins. Spatially guided proteomics addresses this limitation by using tissue imaging techniques to select regions of interest (ROIs) for localized analysis by liquid ...
Kenneth Weke, Julian J. Lum, David R. Goodlett, Helena Pětrošová, Irena Dapic   +4 more
wiley   +1 more source

Identification of protein networks involved in the disease course of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. [PDF]

PLoS ONE, 2012
A more detailed insight into disease mechanisms of multiple sclerosis (MS) is crucial for the development of new and more effective therapies. MS is a chronic inflammatory autoimmune disease of the central nervous system.
Annelies Vanheel, Ruth Daniels, Stéphane Plaisance, Kurt Baeten, Jerome J A Hendriks, Pierre Leprince, Debora Dumont, Johan Robben, Bert Brône, Piet Stinissen, Jean-Paul Noben, Niels Hellings   +11 more
doaj   +1 more source