Results 71 to 80 of about 13,094 (201)

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis

Frontiers in Immunology, 2019
Immune responses to citrullinated peptides have been described in autoimmune diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS). We investigated the post-translational modification (PTM), arginine to citrulline, in brain tissue of MS ...
Wolfgang Faigle, Carolina Cruciani, Witold Wolski, Bernd Roschitzki, Marco Puthenparampil, Paula Tomas-Ojer, Carla Sellés-Moreno, Thomas Zeis, Ivan Jelcic, Nicole Schaeren-Wiemers, Mireia Sospedra, Roland Martin   +11 more
doaj   +1 more source

Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells

The FEBS Journal, EarlyView.
D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono, Yuji Shishido, Toshiyuki Yamagishi, Kiyoshi Fukui   +3 more
wiley   +1 more source

Mass spectrometry imaging with high resolution in mass and space [PDF]

, 2013
Mass spectrometry (MS) imaging links molecular information and the spatial distribution of analytes within a sample. In contrast to most histochemical techniques, mass spectrometry imaging can differentiate molecular modifications and does not require ...
Andreas Römpp, Bernhard Spengler
core   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Proteomics analysis of periplaque and chronic inactive multiple sclerosis lesions

Frontiers in Molecular Neuroscience
BackgroundMultiple sclerosis (MS) is a demyelinating disease of the central nervous system characterized by increased inflammation and immune responses, oxidative injury, mitochondrial dysfunction, and iron dyshomeostasis leading to demyelination and ...
Jordan M. Wilkins, Kiran K. Mangalaparthi, Brian C. Netzel, William A. Sherman, Yong Guo, Alicja Kalinowska-Lyszczarz, Akhilesh Pandey, Claudia F. Lucchinetti   +7 more
doaj   +1 more source

Immune dysregulation in mania: A proof‐of‐concept platelet proteomics study

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data‐driven, unbiased approach to uncover biological alterations.
Paola Magioncalda, Matteo Martino, Nhi Thao Ngoc Le, Wen‐Yin Chen, Ming‐Chyi Huang, David Blum, Thierry Burnouf   +6 more
wiley   +1 more source

Proteomic analysis of phosphoproteins and its application to myelin basic proteins.

SEIBUTSU BUTSURI KAGAKU, 2005
従来タンパク質のリン酸化は, ラジオアイソトープ標識法やウエスタンブロット法を用いて研究されてきたが, 我々は質量分析法による高感度分析法の有効性について基礎的な検討を行った. まずリン酸化部位が既知の標準ペプチドやカゼインを用いて, Post-source decay モードによるMALDI-TOF質量分析を行い, セリンおよびトレオニンリン酸化ペプチド検出における有効性を確認した. しかしチロシンリン酸化ペプチドには, 必ずしも有効ではないこともわかった. 検出感度を上げるために, 市販のリン酸化ペプチドおよびリン酸化タンパク質濃縮キットの使用方法の最適化を行い, 有効性を確認した. さらに我々はこの方法をラットミエリンのミエリン塩基性タンパク質の分析に応用し, リン酸化ペプチドの高感度検出と,
Kyoichi Akiyama, Nobuko Shimada, Narimichi Kimura, Tosifusa Toda   +3 more
openaire   +2 more sources

Age-dependent transcriptome and proteome following transection of neonatal spinal cord of Monodelphis domestica (South American grey short-tailed opossum). [PDF]

PLoS ONE, 2014
This study describes a combined transcriptome and proteome analysis of Monodelphis domestica response to spinal cord injury at two different postnatal ages.
Norman R Saunders, Natassya M Noor, Katarzyna M Dziegielewska, Benjamin J Wheaton, Shane A Liddelow, David L Steer, C Joakim Ek, Mark D Habgood, Matthew J Wakefield, Helen Lindsay, Jessie Truettner, Robert D Miller, A Ian Smith, W Dalton Dietrich   +13 more
doaj   +1 more source

A Systematic Review of Tissue and Single Cell Transcriptome/Proteome Studies of the Brain in Multiple Sclerosis

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system (CNS). Although inflammatory responses are efficiently treated, therapies for progression are scarce and suboptimal, and biomarkers to predict
Maria L. Elkjaer, Maria L. Elkjaer, Maria L. Elkjaer, Richard Röttger, Jan Baumbach, Zsolt Illes, Zsolt Illes, Zsolt Illes   +7 more
doaj   +1 more source