Results 71 to 80 of about 5,726 (179)

Role of myelin-associated NAD+- dependent deacetylase Sirtuin 2 in modifying axonal degeneration [PDF]

, 2012
In the central nervous system (CNS), oligodendrocytes (OLs) ensheath axons with lipid-rich myelin membranes that provide an electrical insulation and are essential for fast nerve impulse transmission. However, myelination is not the only function of OLs,
Kasapoglu, Burcu
core   +1 more source

Identification of protein networks involved in the disease course of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. [PDF]

PLoS ONE, 2012
A more detailed insight into disease mechanisms of multiple sclerosis (MS) is crucial for the development of new and more effective therapies. MS is a chronic inflammatory autoimmune disease of the central nervous system.
Annelies Vanheel, Ruth Daniels, Stéphane Plaisance, Kurt Baeten, Jerome J A Hendriks, Pierre Leprince, Debora Dumont, Johan Robben, Bert Brône, Piet Stinissen, Jean-Paul Noben, Niels Hellings   +11 more
doaj   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein citrullination, driven by peptidyl arginine deiminases (PAD2, PAD4), is linked to multiple diseases. Using a combinatorial peptide library and advanced mass spectrometry, we reveal distinct substrate selectivity profiles of PAD2 and PAD4. While PAD2 broadly citrullinates arginine‐containing peptides, PAD4 is highly sequence‐restricted, with ...
Adina Borbély, Arnold Steckel, Dávid Papp, Domonkos Pál, Katalin Uray, Viktória Goldschmidt Gőz, Gitta Schlosser   +6 more
wiley   +1 more source

Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Sex differences are increasingly recognized as central to the biology of Alzheimer's disease (AD), yet the mechanisms through which they shape brain metabolism and disease vulnerability remain incompletely understood. Brain glucose hypometabolism is a core hallmark of AD and emerges decades before clinical decline, but accumulating evidence ...
Marjan Ramezan, Aphrodite Demetriou, Sara Nicole Burke, Ivan Nalvarte, Andrew C. Shin   +4 more
wiley   +1 more source

Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture Models

Frontiers in Cell and Developmental Biology, 2020
Disease modeling requires appropriate cellular models that best mimic the underlying pathophysiology. Human origin and an adequate expression of the disease protein are pre-requisites that support information from a model to be meaningful.
Stefan Hauser, Stefan Hauser, Stefanie Schuster, Stefanie Schuster, Stefanie Schuster, Elena Heuten, Philip Höflinger, Philip Höflinger, Philip Höflinger, Jakob Admard, Yvonne Schelling, Yvonne Schelling, Ana Velic, Boris Macek, Stephan Ossowski, Stephan Ossowski, Ludger Schöls, Ludger Schöls, Ludger Schöls   +18 more
doaj   +1 more source

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

, 2007
Mice lacking the expression of proteolipid protein (PLP)/DM20 in oligodendrocytes provide a genuine model for spastic paraplegia (SPG-2). Their axons are well myelinated but exhibit impaired axonal transport and progressive degeneration, which is ...
Shen, S., Nave, Klaus-Armin, Orfaniotou, Foteini, Möbius, W., Dhaunchak, A., Werner, Hauke B., Brinkmann, Bastian G., Orfaniotou, F., Guarente, L., Casaccia-Bonnefil, Patrizia, Uecker, M., Kuhlmann, K., Shen, Siming, Dimova, K., Brinkmann, B., Uecker, Marina, Möbius, Wiebke, Casaccia-Bonnefil, P., Werner, H., Nave, K., Dimova, Kalina, Kuhlmann, Katja, Guarente, Lenny, Schardt, Anke, Schardt, A., Dhaunchak, Ajit, Jahn, Olaf, Jahn, O.   +27 more
core   +1 more source

Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes relevant to multiple sclerosis

The Journal of Clinical Investigation
Impairment of oligodendrocytes and myelin contributes to neurological disorders including multiple sclerosis (MS), stroke, and Alzheimer’s disease. Regeneration of myelin (remyelination) decreases the vulnerability of demyelinated axons, but this repair ...
Samira Ghorbani, Cenxiao Li, Brian M. Lozinski, Dorsa Moezzi, Charlotte D’Mello, Yifei Dong, Frank Visser, Hongmin Li, Claudia Silva, Mohammadparsa Khakpour, Colin J. Murray, Marie-Ève Tremblay, Mengzhou Xue, V. Wee Yong   +13 more
doaj   +1 more source

Integrative Bioinformatics Analysis Reveals COL13A1 and COL23A1 as Potential Diagnostic and Prognostic Biomarkers in Thyroid Cancer

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Thyroid cancer, the most prevalent endocrine malignancy globally, poses challenges owing to the limited understanding of its molecular drivers. Previous research has highlighted collagen genes, such as COL13A1 and COL23A1, as key players in thyroid cancer.
Md. Wahidul Islam, Md. Minhajur Rahman, Homaira Naznin, Md. Shohel Hossain, Tahmina Akter, Zayeda Akter Shatabde, Md. Jubayer Hossain   +6 more
wiley   +1 more source

Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations

Acta Neuropathologica Communications, 2020
Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin (PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN mutations cause neuronal ceroid lipofuscinosis-11 (CLN11), a lysosome storage disease ...
Meixiang Huang, Erica Modeste, Eric Dammer, Paola Merino, Georgia Taylor, Duc M. Duong, Qiudong Deng, Christopher J. Holler, Marla Gearing, Dennis Dickson, Nicholas T. Seyfried, Thomas Kukar   +11 more
doaj   +1 more source