Results 51 to 60 of about 5,726 (179)

Identification of a septin filament required for CNS myelin integrity [PDF]

, 2013
Axonal integrity and longevity require functionally intact myelin, as demonstrated by the deletion of myelin-specific genes in mice. To identify molecules that contribute to the structural organization of CNS myelin, its protein content was ...
Patzig, J., Patzig, Julia
core   +1 more source

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

eLife, 2019
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2B ...
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski   +21 more
doaj   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

Proteomics of bovine myelin sheath: Characterization of a truncated form of P0 by MALDI-TOF/TOF mass spectrometry [PDF]

Journal of the American Society for Mass Spectrometry, 2006
The glycoprotein P0, the major structural protein of the peripheral nerve myelin, plays a critical role in holding myelin lamellae together via interaction of both extracellular and cytoplasmic domains. Mutations in the human P0 gene give rise to severe and progressive forms of dominantly inherited peripheral neuropathies like CMT1B.
Qualtieri A, Urso E, Le Pera M, Scornaienchi M, Quattrone A, DI DONNA, Leonardo, NAPOLI, Anna Maria Carmela Natale V, SINDONA, Giovanni   +7 more
openaire   +3 more sources

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis

Frontiers in Immunology, 2019
Immune responses to citrullinated peptides have been described in autoimmune diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS). We investigated the post-translational modification (PTM), arginine to citrulline, in brain tissue of MS ...
Wolfgang Faigle, Carolina Cruciani, Witold Wolski, Bernd Roschitzki, Marco Puthenparampil, Paula Tomas-Ojer, Carla Sellés-Moreno, Thomas Zeis, Ivan Jelcic, Nicole Schaeren-Wiemers, Mireia Sospedra, Roland Martin   +11 more
doaj   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Investigation of myelin maintenance and turnover by inducible MPB knock-out in adult mice [PDF]

, 2019
The turnover and maintenance of myelin in the adult CNS Myelin is a multilayered membrane structure generated by oligodendrocytes in the CNS that insulates and supports axons. While most of the oligodendrocyte population differentiates early in life and
Meschkat, M., Meschkat, Martin
core   +1 more source

Proteomics analysis of periplaque and chronic inactive multiple sclerosis lesions

Frontiers in Molecular Neuroscience
BackgroundMultiple sclerosis (MS) is a demyelinating disease of the central nervous system characterized by increased inflammation and immune responses, oxidative injury, mitochondrial dysfunction, and iron dyshomeostasis leading to demyelination and ...
Jordan M. Wilkins, Kiran K. Mangalaparthi, Brian C. Netzel, William A. Sherman, Yong Guo, Alicja Kalinowska-Lyszczarz, Akhilesh Pandey, Claudia F. Lucchinetti   +7 more
doaj   +1 more source