Results 51 to 60 of about 124,147 (190)

Proteomics of bovine myelin sheath: Characterization of a truncated form of P0 by MALDI-TOF/TOF mass spectrometry [PDF]

Journal of the American Society for Mass Spectrometry, 2006
The glycoprotein P0, the major structural protein of the peripheral nerve myelin, plays a critical role in holding myelin lamellae together via interaction of both extracellular and cytoplasmic domains. Mutations in the human P0 gene give rise to severe and progressive forms of dominantly inherited peripheral neuropathies like CMT1B.
Qualtieri A, Urso E, Le Pera M, Scornaienchi M, Quattrone A, DI DONNA, Leonardo, NAPOLI, Anna Maria Carmela Natale V, SINDONA, Giovanni   +7 more
openaire   +3 more sources

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis

Frontiers in Immunology, 2019
Immune responses to citrullinated peptides have been described in autoimmune diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS). We investigated the post-translational modification (PTM), arginine to citrulline, in brain tissue of MS ...
Wolfgang Faigle, Carolina Cruciani, Witold Wolski, Bernd Roschitzki, Marco Puthenparampil, Paula Tomas-Ojer, Carla Sellés-Moreno, Thomas Zeis, Ivan Jelcic, Nicole Schaeren-Wiemers, Mireia Sospedra, Roland Martin   +11 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Proteome and lipidome of myelin

, 2023
Proteom i lipidom mijelina središnjeg i perifernog živčanog sustava velikim su dijelom jednaki u svome sastavu. Proteomi se razlikuju u najzastupljenijem proteinu (proteolipidni protein u središnjem živčanom sustavu i protein nula u perifernom živčanom ...
Pirić, Ana
core   +3 more sources

Metabolomic insights for the authentication and traceability of antibiotic‐free pork: a pilot study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Antibiotic‐free production within the meat supply chain is a source of concern since new voluntary label claims need to be authenticated to prevent fraud. Therefore, an untargeted 1H NMR‐based metabolomics approach coupled to unsupervised (principal component analysis) and supervised (orthogonal partial least squares discriminant ...
Maria Olga Varrà, Maria Pia Fabrile, Sergio Ghidini, Augusta Caligiani, Federico Scali, Veronica Lolli, Giovanni Loris Alborali, Adriana Ianieri, Emanuela Zanardi   +8 more
wiley   +1 more source

Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo [PDF]

, 2012
<b>Background</b> Myelination is an exquisite and dynamic example of heterologous cell-cell interaction, which consists of the concentric wrapping of multiple layers of oligodendrocyte membrane around neuronal axons.
Strachan, D., Susan C Barnett, Edgar Julia M., David Strachan (186501), Ioannidou, K., Julia M Edgar, Kurt I Anderson, Susan C. Barnett (186504), David Strachan, Julia M. Edgar (37537), Anderson, K.I., Barnett, S.C., Strachan David, Kalliopi Ioannidou, Kurt I. Anderson (186499), Edgar, J.M., Kalliopi Ioannidou (186497), Ioannidou Kalliopi, Anderson Kurt I., Barnett Susan C.   +19 more
core   +1 more source

Proteomics analysis of periplaque and chronic inactive multiple sclerosis lesions

Frontiers in Molecular Neuroscience
BackgroundMultiple sclerosis (MS) is a demyelinating disease of the central nervous system characterized by increased inflammation and immune responses, oxidative injury, mitochondrial dysfunction, and iron dyshomeostasis leading to demyelination and ...
Jordan M. Wilkins, Kiran K. Mangalaparthi, Brian C. Netzel, William A. Sherman, Yong Guo, Alicja Kalinowska-Lyszczarz, Akhilesh Pandey, Claudia F. Lucchinetti   +7 more
doaj   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Data_Sheet_1_Proteomic analysis of peripheral nerve myelin during murine aging.docx

, 2023
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Helen Morrison (781686), Reinhard Bauer (437078), Joanna M. Kirkpatrick (13111769), Michael Reuter (268288), Julia Bischoff (17301412), Annemarie Carlstedt (5390936), Emilio Cirri (1386072), Amy Stockdale (17301415), Dario Lucas Helbing (17301409)   +8 more
core   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source