Deep Proteomics of Mouse Skeletal Muscle Enables Quantitation of Protein Isoforms, Metabolic Pathways, and Transcription Factors [PDF]
, 2015 Skeletal muscle constitutes 40% of individual body mass and plays vital roles in locomotion and whole-body metabolism. Proteomics of skeletal muscle is challenging because of highly abundant contractile proteins that interfere with detection of ...
Cox, J. +5 more
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Proteomic analysis of nuclear factors binding to an intronic enhancer in the myelin proteolipid protein gene [PDF]
Journal of Neurochemistry, 2008 AbstractThe myelin proteolipid protein gene (Plp1) encodes the most abundant protein found in CNS myelin, accounting for nearly one‐half of the total protein. Its expression in oligodendrocytes is developmentally regulated – peaking during the active myelination period of CNS development. Previously, we have identified a novel enhancer (designated ASE)
Anna, Dobretsova +4 more
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Acta Neuropathologica Communications, 2018 Although the genetic causes for several rare, familial forms of Alzheimer’s disease (AD) have been identified, the etiology of the sporadic form of AD remains unclear.
Qi Zhang +5 more
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Absence of miRNA-146a Differentially Alters Microglia Function and Proteome
Frontiers in Immunology, 2020 Background: MiR-146a is an important regulator of innate inflammatory responses and is also implicated in cell death and survival.Methods: By sorting CNS resident cells, microglia were the main cellular source of miR-146a.
Nellie A. Martin +20 more
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Myelin-axon interface vulnerability in Alzheimer's disease revealed by subcellular proteomics and imaging of human and mouse brain. [PDF]
Nat NeurosciCai Y +17 more
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Glial βii spectrin contributes to paranode formation and maintenance [PDF]
, 2018 Action potential conduction along myelinated axons depends on high densities of voltage-gated Na channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells in the peripheral nervous ...
Benusa, Savannah D. +12 more
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Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination [PDF]
, 2018 Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD).
Pasquini, Laura Andrea, Thomas, Laura
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Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]
, 2020 Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana +2 more
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Discovery of prognostic biomarker candidates of lacunar infarction by quantitative proteomics of microvesicles enriched plasma. [PDF]
PLoS ONE, 2014 Lacunar infarction (LACI) is a subtype of acute ischemic stroke affecting around 25% of all ischemic stroke cases. Despite having an excellent recovery during acute phase, certain LACI patients have poor mid- to long-term prognosis due to the recurrence ...
Arnab Datta +2 more
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eLife, 2022 The age and sex of studied animals profoundly impact experimental outcomes in biomedical research. However, most preclinical studies in mice use a wide-spanning age range from 4 to 20 weeks and do not assess male and female mice in parallel.
Feng Xian +3 more
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