Results 91 to 100 of about 132,321 (210)

Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more [PDF]

, 2012
B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process.
Mayer, Marie Cathrin, Meinl, Edgar, Marie Cathrin Mayer, Edgar Meinl, Meinl, E., Mayer, M.   +5 more
core   +1 more source

Neurodevelopmental Impact of Prenatal Stress: A Proteomic Analysis of Myelination Disruptions in the Avian Embryo

Developmental Neurobiology
ABSTRACT Prenatal stress, mediated by elevated glucocorticoid (GC) levels, is a relevant modulator of fetal brain development and a known risk factor for neurodevelopmental disorders. Using the avian embryo as a vertebrate model, we injected corticosterone into the yolk on embryonic day 6 (E6) and assessed neurodevelopmental outcomes ...
Bela Gaertner, Gabriela Morosan‐Puopolo, Beate Brand‐Saberi, Charmaine Schücke, Darius Saberi, Katharina Klöster, Simon Faissner, Katrin Marcus, Morris Gellisch, Britta Eggers   +9 more
openaire   +3 more sources

Myelin-axon interface vulnerability in Alzheimer's disease revealed by subcellular proteomics and imaging of human and mouse brain. [PDF]

Nat Neurosci
Myelin ensheathment is essential for rapid axonal conduction, metabolic support and neuronal plasticity. In Alzheimer's disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. We implemented proximity labeling subcellular proteomics of the myelin-axon interface in postmortem human brains from ...
Cai Y, Pinheiro-de-Sousa I, Slobodyanyuk M, Chen F, Huynh T, Kanyo J, Tang P, Fuentes LA, Braker A, Welch R, Huttner A, Tong L, Yuan P, Lam TT, Petsalaki E, Reimand J, Nairn AC, Grutzendler J.   +17 more
europepmc   +3 more sources

Cell Surface Markers Identify Astrocyte Subpopulations in the Adult Hippocampus With a Heterogeneous Response to Aging

Glia, Volume 74, Issue 11, November 2026.
ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo, Marife Cano‐Jaimez, Raquel Anta, Alba Ripollés‐Boix, Fabián Robledo‐Yagüe, Sheila Zúñiga‐Trejos, Helena Mira   +6 more
wiley   +1 more source

Defining the core proteome of the chloroplast envelope membranes [PDF]

, 2013
High-throughput protein localization studies require multiple strategies. Mass spectrometric analysis of defined cellular fractions is one of the complementary approaches to a diverse array of cell biological methods. In recent years, the protein content
Bernd Müller, Enrico eSchleiff, Mirus, Oliver, Stefan Simm, Michael Karas, Papasotiriou, Dimitrios, Papasotiriou, Dimitrios G., Dimitrios G. Papasotiriou, Schleiff, Enrico, Oliver Mirus, Bernd eMüller, Maik eSommer, Matthias S. Leisegang, Sommer, Maik Sascha, Maik S. Sommer, Dimitri ePapasotiriou, Stefan eSimm, Leisegang, Matthias S., Simm, Stefan, Mohamed eIbrahim, Oliver eMirus, Schorge, Tobias, Enrico Schleiff, Ibrahim, Mohamed, Matthias eLeisegang, Mohamed Ibrahim, Michael eKaras, Tobias Schorge, Müller, Bernd, Sommer, Maik S., Leisegang, Matthias, Tobias eSchorge, Karas, Michael   +32 more
core   +1 more source

Quantitative profiling of brain lipid raft proteome in a mouse model of fragile X syndrome.

PLoS ONE, 2015
Fragile X Syndrome, a leading cause of inherited intellectual disability and autism, arises from transcriptional silencing of the FMR1 gene encoding an RNA-binding protein, Fragile X Mental Retardation Protein (FMRP).
Magdalena Kalinowska, Catherine Castillo, Anna Francesconi   +2 more
doaj   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, Volume 36, Issue 6, November 2026.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells

BMC Genomics, 2017
Background The function of the prion protein, involved in the so-called prion diseases, remains a subject of intense debate and the possibility that it works as a pleiotropic protein through the interaction with multiple membrane proteins is somehow ...
J. A. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. E. Futschik, P. M. Rodrigues, E. P. Melo   +7 more
doaj   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, Volume 179, Issue 3, Page 337-349, November 2026.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

A Proteome Map of Axoglial Specializations Isolated and Purified from Human Central Nervous System [PDF]

, 2010
Artículo de publicación ISICompact myelin, the paranode, and the juxtaparanode are discrete domains that are formed on myelinated axons. In humans, neurological disorders associated with loss of myelin, including Multiple Sclerosis, often also result ...
Bar-Or, Amit, Pedraza, Liliana, Dhaunchak, Ajit S., De Faria Junior, Omar, Roth Metcalfe, Alejandro Darío, Colman, David R., Huang, Jeffrey K., Antel, Jack P.   +7 more
core