Results 91 to 100 of about 13,094 (201)

Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen proteomes [PDF]

, 2008
Background: T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherapies because they are relevant to a large proportion of the human population.
Guang Lan Zhang, Asif M Khan, Kellathur N Srinivasan, AT Heiny, KX Lee, Chee Keong Kwoh, J Thomas August, Vladimir Brusic, CAJ Janeway, AW Hudson, IA Doytchinova, TM Williams, V Brusic, V Brusic, C Buteau, W Fischer, AM Khan, V Gupta, JA Berzofsky, S Surman, SA Brown, SK Kim, A Sette, B Trost, M Bhasin, RD King, LA Zadeh, HG Rammensee, L Stern, HG Rammensee, V Brusic, B Peters, HG Rammensee, GL Zhang, GL Zhang, GL Zhang, WM Kast, KN Srinivasan, B Peters, GL Zhang, JH Kessler, MM Bachinsky, R Weissert, F Borras-Cuesta, S Tongchusak, KC Parker, H Singh, B Peters, CK Hattotuwagama, P Donnes, P Donnes, N Petrovsky, M Larsen, S Tenzer, M Gromme, V Brusic, S Tongchusak   +56 more
core   +1 more source

Bioinformatics Approach for Pattern of Myelin-Specific Proteins and Related Human Disorders [PDF]

, 2016
Background: Recent neuroinformatic studies, on the structure-function interaction of proteins, causative agents basis of human disease have implied that dysfunction or defect of different protein classes could be associated with several related diseases.
Nassiri-Asl, Marjan, Pouragahi, Samiie, Sadeghi, Mehdi, Sanati, Mohammad Hossein   +3 more
core  

Fully denaturing two-dimensional electrophoresis of membrane proteins: a critical update [PDF]

, 2008
The quality and ease of proteomics analysis depends on the performance of the analytical tools used, and thus of the performances of the protein separation tools used to deconvolute complex protein samples.
Adessi, Aivaliotis, Aivaliotis, Alla, Ames, Babu, Berlanda Scorza, Berven, Bierczynska-Krzysik, Bisle, Braun, Bunai, Bunai, Burré, Burré, Buxbaum, Carboni, Chevallet, Chevallet, Connolly, Coughenour, Englund, Everberg, Felsted, Ferro, Friso, Galeva, Gatlin, Gianazza, Gyenes, Hagan, Hartinger, Helling, Henningsen, Hjelmeland, Huang, Huang, Jun, Klein, Lescuyer, Liberatori, Lopez, Low, Luche, Lyubimova, Lüddens, MacFarlane, MacFarlane, Mastro, McDonough, Moebius, Molloy, Molloy, Molloy, Mócz, Nandakumar, Navarre, Patton, Paulson, Pedersen, Peirce, Peng, Perdew, Phadke, Quaranta, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rais, Richert, Rubin, Santoni, Santoni, Santoni, Schindler, Schägger, Siroy, Speers, Stanley, Sweetnam, Tastet, Taylor, Unlü, Valot, Veith, Watarai, Werhahn, Wilkins, Williams, Williams, Wittig, Witzmann, Ying, Zahedi   +95 more
core   +5 more sources

Single‐Cell Nanodroplet Processing Proteomics Pipeline for Analysis of Human‐Derived Microglia

PROTEOMICS, Volume 26, Issue 5, Page 59-68, May 2026.
ABSTRACT Single‐cell omics tools provide unique insights into heterogeneous cell populations and their responses to stimuli. For example, single‐cell RNA sequencing has identified several transcriptionally distinct populations of microglia, which are resident immune cells of the central nervous system (CNS) that are responsive to CNS injury, infection,
Ashley N. Ives, James M. Fulcher, Alex R. Bautista, Reta Birhanu Kitata, Sarah M. Williams, David A. Bennett, Philip L. De Jager, Vladislav A. Petyuk   +7 more
wiley   +1 more source

The role of inflammation in age-related disease. [PDF]

, 2013
The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD.
Augustine, Alison Deckhut, Campisi, Judith, Howcroft, T Kevin, Kohanski, Ron, Louis, Germaine Buck, McElhaney, Janet E, Sierra, Felipe, Smith, Martyn T, Wise, Bradley, Wyss-Coray, Tony   +9 more
core   +2 more sources

Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b

PROTEOMICS, Volume 26, Issue 5, Page 86-97, May 2026.
ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk, Katharina Kotschnew, Julia Hahn, Thomas Patschkowski, Gabriele von Fischer von Mollard   +4 more
wiley   +1 more source

Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture Models

Frontiers in Cell and Developmental Biology, 2020
Disease modeling requires appropriate cellular models that best mimic the underlying pathophysiology. Human origin and an adequate expression of the disease protein are pre-requisites that support information from a model to be meaningful.
Stefan Hauser, Stefan Hauser, Stefanie Schuster, Stefanie Schuster, Stefanie Schuster, Elena Heuten, Philip Höflinger, Philip Höflinger, Philip Höflinger, Jakob Admard, Yvonne Schelling, Yvonne Schelling, Ana Velic, Boris Macek, Stephan Ossowski, Stephan Ossowski, Ludger Schöls, Ludger Schöls, Ludger Schöls   +18 more
doaj   +1 more source

Evaluating Protein Enrichment Methods to Improve Biomarker Discovery in Equine Cerebrospinal Fluid

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Here, we compared two protein enrichment methods—ProteoMiner Small‐Capacity and PreOmics Enrich‐iST—for proteomic analysis of equine cerebrospinal fluid (CSF). PreOmics Enrich‐iST achieved superior depletion of high‐abundance proteins and identified a greater number of low‐abundance, neuropathology‐relevant proteins than ProteoMiner or native digestion.
Foti Federico, Wilson Amie, Chabronova Alzbeta, Jensen Anders, Lunn Paul David, Peffers Jayne Mandy   +5 more
wiley   +1 more source

Functional Genomic and Proteomic Analysis Reveals Disruption of Myelin-Related Genes and Translation in a Mouse Model of Early Life Neglect [PDF]

Frontiers in Psychiatry, 2011
Early life neglect is an important public health problem which can lead to lasting psychological dysfunction. Good animal models are necessary to understand the mechanisms responsible for the behavioral and anatomical pathology that results. We recently described a novel model of early life neglect, maternal separation with early weaning (MSEW), that ...
Bordner, Kelly A., George, Elizabeth D., Carlyle, Becky C., Duque, Alvaro, Kitchen, Robert R., Lam, TuKiet T., Colangelo, Christopher M., Stone, Kathryn L., Abbott, Thomas B., Mane, Shrikant M., Nairn, Angus C., Simen, Arthur A.   +11 more
openaire   +3 more sources

Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic function [PDF]

, 2012
There is still a lack in the molecular comprehension of major depressive disorder (MDD) although this condition affects approximately 10% of the world population.
BK Krueger, C Bouquet, C Sinclair, CL Beasley, D Martins-De-Souza, D Martins-de-Souza, D Martins-de-Souza, D Martins-de-Souza, D Martins-de-Souza, D Martins-de-Souza, D Martins-de-Souza, D Martins-de-Souza, D Mehta, Daniel Martins-de-Souza, DP Hanger, E Parlapani, ES Lander, F Onofri, F Porro, FR Lucas, GT Rezin, GZ Li, H Schulman, Hassan Rahmoune, J Al-Bassam, J Lippincott-Schwartz, JC Venter, JE Kleinman, JR Henley, K Ashman, K Hensley, KG Oikonomou, KJ Rothman, LR Baxter Jr, M Fava, M Goedert, M Kanarik, M Kantorow, M Koenigs, M Mueller, M Nozumi, M Tochigi, M Zervas, N Cavallarin, N Launay, N Ozlu, Natacha Vanattou-Saifoudine, P Duprey, Paul C. Guest, PE Greenberg, PJ Harrison, PJ Harrison, PK Chong, Sabine Bahn, SH Kennedy, SI Walaas, TC Sudhof, V Bennett, V Bennett, V Pigaga, W Wickner, Y Benjamini, Y Yamagata   +62 more
core   +2 more sources