Results 91 to 100 of about 5,726 (179)

Target Proteins in the Dorsal Hippocampal Formation Sustain the Memory-Enhancing and Neuroprotective Effects of Ginkgo biloba

Frontiers in Pharmacology, 2019
We have previously shown that standardized extracts of Ginkgo biloba (EGb) modulate fear memory formation, which is associated with CREB-1 (mRNA and protein) upregulation in the dorsal hippocampal formation (dHF), in a dose-dependent manner.
Renan Barretta Gaiardo, Thiago Ferreira Abreu, Alexandre Keiji Tashima, Monica Marques Telles, Suzete Maria Cerutti   +4 more
doaj   +1 more source

Hypothalamic protein profiling from mice subjected to social defeat stress

Molecular Brain
The Hypothalmic-Pituitary-Adrenal axis also known as the HPA axis is central to stress response. It also acts as the relay center between the body and the brain.
Shiladitya Mitra, Ghantasala S. Sameer Kumar, Anumita Samanta, Mathias V. Schmidt, Suman S. Thakur   +4 more
doaj   +1 more source

Proteome profile of the cerebellum from α7 nicotinic acetylcholine receptor deficient mice [PDF]

The alpha7 nicotinic acetylcholine receptor (α7 nAChR; CHRNA7) is expressed in the nervous system and in non-neuronal tissues. Within the central nervous system, it is involved in various cognitive and sensory processes such as learning, attention, and ...
Stöckl, Jan Bernard, Caban, Karolina Magdalena, Seßenhausen, Pia, Popper, Bastian, Mayerhofer, Artur, Fröhlich, Thomas   +5 more
core   +1 more source

Huntington's disease: An immune perspective [PDF]

, 2011
Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund.Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide ...
Kishore, U, Domenico Marco Bonifati, Ansar, R, Verma, SK, Rafia Ansar, Nayak, A, Sunil K. Verma, Annapurna Nayak, Bonifati, DM, Uday Kishore   +9 more
core   +1 more source

Comparative proteomics of the Mycobacterium leprae binding protein myelin P0: its implication in leprosy and other neurodegenerative diseases

Infection, Genetics and Evolution, 2004
Mycobacterium leprae, the causative agent of leprosy invades Schwann cells of the peripheral nerves leading to nerve damage and disfigurement, which is the hallmark of the disease. Wet experiments have shown that M. leprae binds to a major peripheral nerve protein, the myelin P zero (P0).
Deena, Vardhini, Sujai, Suneetha, Niyaz, Ahmed, D S M, Joshi, S, Karuna, X, Magee, D S R, Vijayalakshmi, V, Sridhar, K V, Karunakar, Juan J, Archelos, Lavanya M, Suneetha   +10 more
openaire   +2 more sources

Proteomic changes induced by hepcidin 1 injection in brain and skin of juvenile gilthead seabream (Sparus aurata)

Aquaculture Reports
The present study investigated the effects of hepcidin 1 (Hamp1) on the brain and skin proteomes of juvenile gilthead seabream (Sparus aurata).
Laura García-Navarro, Claudia Marín-Parra, Jhon A. Serna Duque, M. Ángeles Esteban   +3 more
doaj   +1 more source

Proteomic prediction of myelin water fraction using the SomaScan 7k platform

Alzheimer's & Dementia
AbstractBackgroundMyelin loss occurs as part of neurodegenerative and neuroinflammatory conditions. Myelin water fraction (MWF), a surrogate of myelin content, can be estimated using multicomponent relaxometry MRI. In this study we investigate the relationship between 7289 plasma proteins and MWF to derive a protein‐based indicator of myelin content ...
Joynes, Cassandra M, Resnick, Susan M., Bouhrara, Mustapha, Walker, Keenan A.   +3 more
openaire   +1 more source

The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination [PDF]

, 2019
Oligodendrocytes extend elaborate microtubule arbors that contact up to 50 axon segments per cell, then spiral around myelin sheaths, penetrating from outer to inner layers. However, how they establish this complex cytoarchitecture is unclear.
McAlear, Thomas S, Huang, Ting-Ting, Bechstedt, Susanne, Barres, Ben A, Perrino, John J, Nguyen, Huy, Fu, Meng-Meng, Burlingame, Alma L, Shi, Rebecca D, Valenzuela, Alex, Oses-Prieto, Juan A   +10 more
core   +1 more source

Cerebrospinal fluid lipoprotein-mediated cholesterol delivery to neurons is impaired in Alzheimer's disease and involves APOE4

Journal of Lipid Research
In the central nervous system, apolipoprotein (APO)E-containing lipoprotein particles mediate the transport of glial-derived cholesterol to neurons, which is essential for neuronal membrane remodeling and maintenance of the myelin sheath.
Carla Borràs, Marina Canyelles, David Santos, Noemí Rotllan, Estefanía Núñez, Jesús Vázquez, Daniel Maspoch, Mary Cano-Sarabia, Qi Zhao, Maria Carmona-Iragui, Sònia Sirisi, Alberto Lleó, Juan Fortea, Daniel Alcolea, Francisco Blanco-Vaca, Joan Carles Escolà-Gil, Mireia Tondo   +16 more
doaj   +1 more source

Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia

, 2010
Schizophrenia (SCZ) is the result of DNA alterations and environmental factors, which together lead to differential protein expression and ultimately to the development of the illness.
Maccarrone, Giuseppina, Gormanns, P., Schmitt, A., Zerr, I., Zerr, Inga, Falkai, Peter, Falkai, P., Maccarrone, G., Wobrock, Thomas, Gormanns, Philipp, Reckow, S., Turck, C. W., Turck, C., Martins-de-Souza, D., Wobrock, T., Reckow, Stefan, Martins-de-Souza, Daniel, Turck, Christoph W., Schmitt, Andrea   +18 more
core   +1 more source