Results 111 to 120 of about 13,094 (201)

Quantitative profiling of brain lipid raft proteome in a mouse model of fragile X syndrome.

PLoS ONE, 2015
Fragile X Syndrome, a leading cause of inherited intellectual disability and autism, arises from transcriptional silencing of the FMR1 gene encoding an RNA-binding protein, Fragile X Mental Retardation Protein (FMRP).
Magdalena Kalinowska, Catherine Castillo, Anna Francesconi   +2 more
doaj   +1 more source

A method to identify p62’s UBA domain interacting proteins [PDF]

, 2003
The UBA domain is a conserved sequence motif among polyubiquitin binding proteins. For the first time, we demonstrate a systematic, high throughput approach to identification of UBA domain-interacting proteins from a proteome-wide perspective.
Julia W. Pridgeon, Thangiah Geetha, Marie W. Wooten   +2 more
core   +1 more source

Proteomic prediction of myelin water fraction using the SomaScan 7k platform

Alzheimer's & Dementia
AbstractBackgroundMyelin loss occurs as part of neurodegenerative and neuroinflammatory conditions. Myelin water fraction (MWF), a surrogate of myelin content, can be estimated using multicomponent relaxometry MRI. In this study we investigate the relationship between 7289 plasma proteins and MWF to derive a protein‐based indicator of myelin content ...
Joynes, Cassandra M, Resnick, Susan M., Bouhrara, Mustapha, Walker, Keenan A.   +3 more
openaire   +1 more source

Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells

BMC Genomics, 2017
Background The function of the prion protein, involved in the so-called prion diseases, remains a subject of intense debate and the possibility that it works as a pleiotropic protein through the interaction with multiple membrane proteins is somehow ...
J. A. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. E. Futschik, P. M. Rodrigues, E. P. Melo   +7 more
doaj   +1 more source

Comprehensive Phenotyping in Multiple Sclerosis: Discovery Based Proteomics and the Current Understanding of Putative Biomarkers [PDF]

, 2014
Currently, there is no single test for multiple sclerosis (MS). Diagnosis is confirmed through clinical evaluation, abnormalities revealed by magnetic resonance imaging (MRI), and analysis of cerebrospinal fluid (CSF) chemistry.
Becker, Christopher H., Hafler, David A., Kantor, Aaron B., O’Connor, Kevin C., Roy, Sushmita Mimi   +4 more
core   +1 more source

Comparative proteomics of the Mycobacterium leprae binding protein myelin P0: its implication in leprosy and other neurodegenerative diseases

Infection, Genetics and Evolution, 2004
Mycobacterium leprae, the causative agent of leprosy invades Schwann cells of the peripheral nerves leading to nerve damage and disfigurement, which is the hallmark of the disease. Wet experiments have shown that M. leprae binds to a major peripheral nerve protein, the myelin P zero (P0).
Deena, Vardhini, Sujai, Suneetha, Niyaz, Ahmed, D S M, Joshi, S, Karuna, X, Magee, D S R, Vijayalakshmi, V, Sridhar, K V, Karunakar, Juan J, Archelos, Lavanya M, Suneetha   +10 more
openaire   +2 more sources

Health related effects of wheat varieties [PDF]

, 2020
Summarises the different effects wheat digestion has on human ...
Borgen, Anders
core  

Target Proteins in the Dorsal Hippocampal Formation Sustain the Memory-Enhancing and Neuroprotective Effects of Ginkgo biloba

Frontiers in Pharmacology, 2019
We have previously shown that standardized extracts of Ginkgo biloba (EGb) modulate fear memory formation, which is associated with CREB-1 (mRNA and protein) upregulation in the dorsal hippocampal formation (dHF), in a dose-dependent manner.
Renan Barretta Gaiardo, Thiago Ferreira Abreu, Alexandre Keiji Tashima, Monica Marques Telles, Suzete Maria Cerutti   +4 more
doaj   +1 more source

Hypothalamic protein profiling from mice subjected to social defeat stress

Molecular Brain
The Hypothalmic-Pituitary-Adrenal axis also known as the HPA axis is central to stress response. It also acts as the relay center between the body and the brain.
Shiladitya Mitra, Ghantasala S. Sameer Kumar, Anumita Samanta, Mathias V. Schmidt, Suman S. Thakur   +4 more
doaj   +1 more source

Cerebrospinal fluid lipoprotein-mediated cholesterol delivery to neurons is impaired in Alzheimer's disease and involves APOE4

Journal of Lipid Research
In the central nervous system, apolipoprotein (APO)E-containing lipoprotein particles mediate the transport of glial-derived cholesterol to neurons, which is essential for neuronal membrane remodeling and maintenance of the myelin sheath.
Carla Borràs, Marina Canyelles, David Santos, Noemí Rotllan, Estefanía Núñez, Jesús Vázquez, Daniel Maspoch, Mary Cano-Sarabia, Qi Zhao, Maria Carmona-Iragui, Sònia Sirisi, Alberto Lleó, Juan Fortea, Daniel Alcolea, Francisco Blanco-Vaca, Joan Carles Escolà-Gil, Mireia Tondo   +16 more
doaj   +1 more source