Results 111 to 120 of about 132,321 (210)

Cell Type‐Specific Extracellular Vesicles in Mouse Brain: Proteomic Signatures Highlight Astrocytic GlialCAM Network and GPCR Enrichment

Glia, Volume 74, Issue 10, October 2026.
Cell type–specific EVs were isolated from mouse brain and profiled by proteomics. Each EV subtype exhibited proteomic signatures consistent with the specialized functions of its cell of origin. Astrocyte‐derived EVs (ADEVs) were enriched for the GlialCAM/MLC1 network and GPCRs.
Alba M. Lucart‐Sanchez, Edward Sellés‐Climent, Jorge Navarro‐Calvo, Guillem Pont‐Espinós, Jose A. Gomez‐Sanchez, Raúl Estévez, Luis M. Valor, Rocío Pérez‐González   +7 more
wiley   +1 more source

AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model

Journal of Neuroinflammation
Background A Proliferation-Inducing Ligand (APRIL) is a tumour necrosis factor superfamily member with multiple effector roles in the peripheral and central nervous system (CNS).
Leonardo Ricciardi, Federica Di Marco, Marion Decrop, Julia Di Stefano, Tejaswini Kakunuri, Joëlle van Rijswijk, Nicholas Vidas-Guscic, Yousra El Ouaamari, Alexandro A. Bufi, Ignace Van Spilbeeck, Johan Van Audekerke, Carole Faghel, Esther Bartholomeus, Eva Lion, Nathalie Cools, Steven Van Laere, Ilaria Cicalini, Vincenzo De Laurenzi, Una FitzGerald, Damiana Pieragostino, Bertrand Huard, Piero Del Boccio, Peter Ponsaerts, Marleen Verhoye   +23 more
doaj   +1 more source

Proteomic changes induced by hepcidin 1 injection in brain and skin of juvenile gilthead seabream (Sparus aurata)

Aquaculture Reports
The present study investigated the effects of hepcidin 1 (Hamp1) on the brain and skin proteomes of juvenile gilthead seabream (Sparus aurata).
Laura García-Navarro, Claudia Marín-Parra, Jhon A. Serna Duque, M. Ángeles Esteban   +3 more
doaj   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Conserved and Tissue‐Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
A whole‐body map of sEVs from a single pig, including 133 samples spanning 10 systems, revealed striking tissue‐specific heterogeneity in yield. Importantly, a conserved core cargo set comprising candidate sEV markers (ACTG1, CFL1, and ANXA2), RNA‐binding proteins, the let‐7 miRNA family, and ferritin genes was defined from 105,409 (88.6% full‐length ...
Naixiang Yu, Jinxiu Liu, Chenliang Lai, Siyi Liu, Jiacheng Wei, Jiahong Zhong, Sanya Xiong, Qingjie Zeng, Junwu Ma, Zhou Zhang, Zhiyan Zhang   +10 more
wiley   +1 more source

Acute Neurological Manifestations in COVID‐19 Are Associated With Complement Activation and Glia‐Promoted Neuroinflammation

Journal of Medical Virology, Volume 98, Issue 10, October 2026.
ABSTRACT Pathophysiological mechanisms of neurological manifestations in COVID‐19 are not fully known yet. In this case‐control study, proteomic analysis was used to characterize cerebrospinal fluid (CSF) samples from COVID‐19 patients with acute neurological manifestations primarily categorized as: isolated refractory headache (n = 12), encephalopathy
Nicole Lardini Freitas, Yago Côrtes Pinheiro Gomes, Fábio César Sousa Nogueira, Juliana Echevarria‐Lima, João Victor Carvalho Deus, Carlos Otávio Brandão, Cristiane Nascimento Soares, Marcus Tulius Teixeira Silva, Otávio Melo Espíndola   +8 more
wiley   +1 more source

Domain-specific proteome remodeling defines mouse myelin aging

Abstract Myelin, once regarded as a static insulating structure, is now recognized as a dynamic component of the nervous system, capable of remodeling in response to experience. Its breakdown is linked to cognitive decline and neurodegenerative diseases, often preceding neuronal dysfunction.
Yarden Freund, Michael Schoof, Noa Moreno, Florian Kriegel, Heather Shin, Vanessa Waelchli, Achint Kaur, Kevin Abraham, Ido Fogel, Sophia M. Shi, Ning-Sum To, Ian H. Guldner, Tom H. Cheung, Andrew C Yang, Andreas Keller, Tony Wyss-Coray, Tal Iram   +16 more
openaire   +1 more source

The chaperonin TRiC component Cct3 is required for axonal transport, myelination, and neuromuscular junction refinement

Cell Death and Disease
TRiCopathies are recently discovered neurodevelopmental diseases caused by pathogenic variants in components of the chaperonin tailless complex polypeptide 1 ring complex (TRiC).
Xiaomeng Zhang, Kamil Kajetan Zajt, Tayfun Palaz, Lisa Wang, Martin Groß, Florian Kraft, Joachim Weis, Juliane Bremer   +7 more
doaj   +1 more source

Cerebrospinal fluid lipoprotein-mediated cholesterol delivery to neurons is impaired in Alzheimer's disease and involves APOE4

Journal of Lipid Research
In the central nervous system, apolipoprotein (APO)E-containing lipoprotein particles mediate the transport of glial-derived cholesterol to neurons, which is essential for neuronal membrane remodeling and maintenance of the myelin sheath.
Carla Borràs, Marina Canyelles, David Santos, Noemí Rotllan, Estefanía Núñez, Jesús Vázquez, Daniel Maspoch, Mary Cano-Sarabia, Qi Zhao, Maria Carmona-Iragui, Sònia Sirisi, Alberto Lleó, Juan Fortea, Daniel Alcolea, Francisco Blanco-Vaca, Joan Carles Escolà-Gil, Mireia Tondo   +16 more
doaj   +1 more source

Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy

MedComm, Volume 7, Issue 10, October 2026.
Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu, Mengling You, Yi Zeng, Jinglin Zhang, Si Chen, Rong Rong, Xiaobo Xia   +6 more
wiley   +1 more source