Results 101 to 110 of about 5,726 (179)

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Vulnerability of the Myelin‐Axon Interface Uncovered by Subcellular Proteomics and Imaging of Alzheimer's Human Brain

Alzheimer's & Dementia
Abstract Background Myelin ensheathment is essential for rapid axonal electrical conduction, metabolic support and neuronal plasticity. In Alzheimer's disease (AD), disruptions in both myelin and axonal structures occur; however, the underlying mechanisms remain poorly understood.
Cai, Yifei, Pinheiro‐de‐Sousa, Iguaracy, Slobodyanyuk, Mykhaylo, Chen, Fuyi, Huynh, Tram, Kanyo, Jean E., Tang, Peiyang, Fuentes, Lukas A., Braker, Amber, Welch, Rachel, Anita, Huttner J., Tong, Lei, Yuan, Peng, Lam, TuKiet, Petsalaki, Evangelia, Reimand, Jüri, Nairn, Angus C, Grutzendler, Jaime   +17 more
openaire   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Proteomic signatures of physical, cognitive, and imaging outcomes in multiple sclerosis

Annals of Clinical and Translational Neurology
Background A quantitative measurement of serum proteome biomarkers that would associate with disease progression endpoints can provide risk stratification for persons with multiple sclerosis (PwMS) and supplement the clinical decision‐making process ...
Kian Jalaleddini, Dejan Jakimovski, Anisha Keshavan, Shannon McCurdy, Kelly Leyden, Ferhan Qureshi, Atiyeh Ghoreyshi, Niels Bergsland, Michael G. Dwyer, Murali Ramanathan, Bianca Weinstock‐Guttman, Ralph HB Benedict, Robert Zivadinov   +12 more
doaj   +1 more source

The sHsp expression signature in the brain and modulation in models of chronic neurodegeneration

, 2010
Intrinsic protein folding pathways are modulated by molecular chaperones, such as the diversegroup of heat shock proteins (Hsps). Among these is the small heat shock protein (sHsp)family which in the mammalian genome consists of 10 low molecular weight ...
Quraishe, Shmma
core  

Proteomic Analysis of the Highly Detergent Resistant Radial component of Myelin

, 2012
The wrapping of multiple layers of myelin membrane sheets around an axon plays an important role in normal neuronal function. In the central nervous system (CNS), oligodendrocytes are responsible for forming multiple myelin internodes which consist of ...
Patel, Vatsal M
core  

Analysis of the mitochondrial proteome in multiple sclerosis cortex

, 2011
Mitochondrial dysfunction has been proposed to play a role in the neuropathology of multiple sclerosis (MS). Previously, we reported significant alterations in the transcription of nuclear-encoded electron transport chain genes in MS and confirmed ...
McDonough, Jennifer, Robert Clements, Roger B. Gregory, Pandit, Ashish, Yong, V. Wee, Laurie Broadwater, Freeman, Ernest J., Ashish Pandit, Michael Sulak, Jonathan Vadnal, Sulak, Michael, Sausan Azzam, Ernest J. Freeman, Jennifer McDonough, Clements, Robert, Vadnal, Jonathan, Azzam, Sausan, V. Wee Yong, Gregory, Roger B., Broadwater, Laurie   +19 more
core   +1 more source

Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination

eBioMedicine
The association between childhood obesity and language development may be confounded by socio-environmental factors and attributed to comorbid pathways.In a longitudinal Singaporean mother-offspring cohort, we leveraged trans-ancestry polygenic predictions of body mass index (BMI) to interrogate the causal effects of early-life BMI on child language ...
Jian Huang, Jinyi Che, Michelle Z.L. Kee, Ai Peng Tan, Evelyn C. Law, Patricia Pelufo Silveira, Irina Pokhvisneva, Sachin Patel, Keith M. Godfrey, Lourdes Mary Daniel, Kok Hian Tan, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Dennis Wang, Jonathan Yinhao Huang   +15 more
openaire   +7 more sources

Myelin matters: proteomic insights into white matter disorders

Expert Review of Proteomics, 2010
Werner, H., Jahn, O.
openaire   +4 more sources

ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS

European Journal of Histochemistry
Autosomal Dominant Leukodystrophy (ADLD) is a rare, fatal neurodegenerative disorder caused by LMNB1 gene overexpression, leading to progressive central nervous system demyelination with no effective therapy.
doaj   +1 more source