Results 101 to 110 of about 132,321 (210)

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, Volume 13, Issue 56, 9 October 2026.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Proteomic prediction of myelin water fraction using the SomaScan 7k platform

Alzheimer's & Dementia
AbstractBackgroundMyelin loss occurs as part of neurodegenerative and neuroinflammatory conditions. Myelin water fraction (MWF), a surrogate of myelin content, can be estimated using multicomponent relaxometry MRI. In this study we investigate the relationship between 7289 plasma proteins and MWF to derive a protein‐based indicator of myelin content ...
Joynes, Cassandra M, Resnick, Susan M., Bouhrara, Mustapha, Walker, Keenan A.   +3 more
openaire   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Structure of myelin P2 protein from equine spinal cord [PDF]

, 2005
Equine P2 protein has been isolated from horse spinal cord and its structure determined to 2.1 Å. Since equine myelin is a viable alternative to bovine tissue for large-scale preparations, characterization of the proteins from equine spinal cord ...
Riboldi-Tunnicliffe, A., Riboldi-Tunnicliffe, A, Freer, A.A., Hunter, DJB, Hunter, D.J.B., Griffiths, IR, Roszak, A.W., Macmaster, R, Roszak, AW, Macmaster, R., Griffiths, I.R., Freer, AA   +11 more
core   +1 more source

Target Proteins in the Dorsal Hippocampal Formation Sustain the Memory-Enhancing and Neuroprotective Effects of Ginkgo biloba

Frontiers in Pharmacology, 2019
We have previously shown that standardized extracts of Ginkgo biloba (EGb) modulate fear memory formation, which is associated with CREB-1 (mRNA and protein) upregulation in the dorsal hippocampal formation (dHF), in a dose-dependent manner.
Renan Barretta Gaiardo, Thiago Ferreira Abreu, Alexandre Keiji Tashima, Monica Marques Telles, Suzete Maria Cerutti   +4 more
doaj   +1 more source

Proteomic Signatures of Noise‐Induced Hearing Loss in the Mouse Cochlea

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Hearing loss affects over 1.5 billion people worldwide and has substantial social, educational, and economic consequences. Although genetic studies have identified numerous hearing‐loss‐associated genes, the molecular changes accompanying noise‐induced hearing loss (NIHL) remain incompletely understood.
Ana Carla Batissoco, Danillo Alencar‐Coutinho, Ana Carolina Ferreira‐Scatone, Stella Diogo‐Cavassana, Jeanne Oiticica, Karina Lezirovitz, Ricardo Ferreira Bento   +6 more
wiley   +1 more source

The 2023 Report on the Proteome from the HUPO Human Proteome Project. [PDF]

Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two ...
Van Eyk, Jennifer E, Aebersold, Ruedi,, Omenn, Gilbert S.,, Bandeira, Nuno,, Overall, Christopher M.,, Pineau, Charles,, Liu, Siqi,, Bandeira, Nuno, Van Eyk, Jennifer E.,, Weintraub, Susan T.,, Deutsch, Eric W.,, Cristea, Ileana M.,, Roehrl, Michael H. A.,, Orchard, Sandra,, Nice, Edouard,, Nice, Edouard, Liu, Siqi, Moritz, Robert L, Deutsch, Eric W, Omenn, Gilbert S, Lindskog, Cecilia, Cristea, Ileana M, Packer, Nicolle H.,, Roehrl, Michael HA, Guo, Tiannan, Aebersold, Ruedi, Lindskog, Cecilia,, Roehrl, Michael H A, Lane, Lydie,, Packer, Nicolle H, Overall, Christopher M, Weintraub, Susan T, Orchard, Sandra, Pineau, Charles, Guo, Tiannan,, et al., Lane, Lydie, Moritz, Robert L.,   +37 more
core   +1 more source

Combined transcriptomic and proteomic analyses reveal relevant myelin features in mice with ischemic stroke

Functional & Integrative Genomics
Ischemic stroke (IS), a leading cause of global disability and mortality, is characterized by white matter damage and demyelination. Despite advances, the molecular mechanisms driving post-IS myelin pathology remain poorly understood, limiting therapeutic development. This study investigates key myelin-related genes (MRGs) and their regulatory networks
Qiuyang Qian, Hao Lyu, Wei Wang, Qiwen Wang, Desheng Li, Xiaojia Liu, Yi He, Mei Shen   +7 more
openaire   +2 more sources

Hypothalamic protein profiling from mice subjected to social defeat stress

Molecular Brain
The Hypothalmic-Pituitary-Adrenal axis also known as the HPA axis is central to stress response. It also acts as the relay center between the body and the brain.
Shiladitya Mitra, Ghantasala S. Sameer Kumar, Anumita Samanta, Mathias V. Schmidt, Suman S. Thakur   +4 more
doaj   +1 more source