Results 101 to 110 of about 124,147 (190)

avdvorak/myelin-atlas: version 1.0.1

, 2020
Example code for the analysis pipeline used to create the structural template and quantitative myelin water imaging atlases for An atlas for human brain myelin content throughout the adult life span https://www.nature.com/articles/s41598-020-79540-
Dvorak, Adam V.
core   +1 more source

Proteomic changes induced by hepcidin 1 injection in brain and skin of juvenile gilthead seabream (Sparus aurata)

Aquaculture Reports
The present study investigated the effects of hepcidin 1 (Hamp1) on the brain and skin proteomes of juvenile gilthead seabream (Sparus aurata).
Laura García-Navarro, Claudia Marín-Parra, Jhon A. Serna Duque, M. Ángeles Esteban   +3 more
doaj   +1 more source

The chaperonin TRiC component Cct3 is required for axonal transport, myelination, and neuromuscular junction refinement

Cell Death and Disease
TRiCopathies are recently discovered neurodevelopmental diseases caused by pathogenic variants in components of the chaperonin tailless complex polypeptide 1 ring complex (TRiC).
Xiaomeng Zhang, Kamil Kajetan Zajt, Tayfun Palaz, Lisa Wang, Martin Groß, Florian Kraft, Joachim Weis, Juliane Bremer   +7 more
doaj   +1 more source

Cerebrospinal fluid lipoprotein-mediated cholesterol delivery to neurons is impaired in Alzheimer's disease and involves APOE4

Journal of Lipid Research
In the central nervous system, apolipoprotein (APO)E-containing lipoprotein particles mediate the transport of glial-derived cholesterol to neurons, which is essential for neuronal membrane remodeling and maintenance of the myelin sheath.
Carla Borràs, Marina Canyelles, David Santos, Noemí Rotllan, Estefanía Núñez, Jesús Vázquez, Daniel Maspoch, Mary Cano-Sarabia, Qi Zhao, Maria Carmona-Iragui, Sònia Sirisi, Alberto Lleó, Juan Fortea, Daniel Alcolea, Francisco Blanco-Vaca, Joan Carles Escolà-Gil, Mireia Tondo   +16 more
doaj   +1 more source

Domain-specific proteome remodeling defines mouse myelin aging

Abstract Myelin, once regarded as a static insulating structure, is now recognized as a dynamic component of the nervous system, capable of remodeling in response to experience. Its breakdown is linked to cognitive decline and neurodegenerative diseases, often preceding neuronal dysfunction.
Yarden Freund, Michael Schoof, Noa Moreno, Florian Kriegel, Heather Shin, Vanessa Waelchli, Achint Kaur, Kevin Abraham, Ido Fogel, Sophia M. Shi, Ning-Sum To, Ian H. Guldner, Tom H. Cheung, Andrew C Yang, Andreas Keller, Tony Wyss-Coray, Tal Iram   +16 more
openaire   +1 more source

Vulnerability of the Myelin‐Axon Interface Uncovered by Subcellular Proteomics and Imaging of Alzheimer's Human Brain

Alzheimer's & Dementia
Abstract Background Myelin ensheathment is essential for rapid axonal electrical conduction, metabolic support and neuronal plasticity. In Alzheimer's disease (AD), disruptions in both myelin and axonal structures occur; however, the underlying mechanisms remain poorly understood.
Cai, Yifei, Pinheiro‐de‐Sousa, Iguaracy, Slobodyanyuk, Mykhaylo, Chen, Fuyi, Huynh, Tram, Kanyo, Jean E., Tang, Peiyang, Fuentes, Lukas A., Braker, Amber, Welch, Rachel, Anita, Huttner J., Tong, Lei, Yuan, Peng, Lam, TuKiet, Petsalaki, Evangelia, Reimand, Jüri, Nairn, Angus C, Grutzendler, Jaime   +17 more
openaire   +1 more source

Improved Membrane Proteomics Coverage of Human Embryonic Stem Cells by Peptide IPG-IEF

, 2009
Protein biomarkers are fundamental tools for the characterization of stem cells and for tracking their differentiation and maturation down developmental lineages.
Schmidt, Uli, Pascovici, Dana, McQuade, Leon, Baker, Mark S. S, Stojanov, Tomas   +4 more
core   +1 more source

An update on the mouse liver proteome

, 2009
Art. 35Background: Decoding of the liver proteome is subject of intense research, but hampered by methodological constraints. We recently developed an improved protocol for studying rat liver proteins based on 2-DE-MALDI-TOF-MS peptide mass finger ...
Borlak, J., Gazzana, G.
core   +1 more source

Immuno-Proteomic Features Associated to Relapse Risk in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Neurology Neuroimmunology & Neuroinflammation
Background and objectives: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder that overlaps clinically with multiple sclerosis (MS) but immunopathologically distinct. Although often considered an acute inflammatory disease, recurrent attacks in MOGAD can lead to demyelination, axonal injury,
Gerardina Gallaccio, Anna Müller, Meng Wang, Lisa-Marie Diekmann, Carolin Otto, Alessandro Dinoto, Vanessa Chiodega, Carolin Schwake, Sven Jarius, Tatiana Usnich, Pia Sophie Sperber, Lina Anderhalten, Tatchaporn Ongphichetmetha, Angus Byars, Deni Subasic, Desiree Kunkel, Ilya Ayzenberg, Sara Mariotto, Sara Samadzadeh, Friedemann Paul, Chotima Böttcher   +20 more
openaire   +1 more source

Proteomic signatures of physical, cognitive, and imaging outcomes in multiple sclerosis

Annals of Clinical and Translational Neurology
Background A quantitative measurement of serum proteome biomarkers that would associate with disease progression endpoints can provide risk stratification for persons with multiple sclerosis (PwMS) and supplement the clinical decision‐making process ...
Kian Jalaleddini, Dejan Jakimovski, Anisha Keshavan, Shannon McCurdy, Kelly Leyden, Ferhan Qureshi, Atiyeh Ghoreyshi, Niels Bergsland, Michael G. Dwyer, Murali Ramanathan, Bianca Weinstock‐Guttman, Ralph HB Benedict, Robert Zivadinov   +12 more
doaj   +1 more source