Results 51 to 60 of about 174,175 (299)

Myelination and mTOR [PDF]

Glia, 2017
AbstractMyelinating cells surround axons to accelerate the propagation of action potentials, to support axonal health, and to refine neural circuits. Myelination is metabolically demanding and, consistent with this notion, mTORC1—a signaling hub coordinating cell metabolism—has been implicated as a key signal for myelination.
Gianluca Figlia, Daniel Gerber, Ueli Suter   +2 more
openaire   +4 more sources

c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. [PDF]

, 2012
The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration.
Jenkins, Billy, Turmaine, Mark, Mirsky, Rhona, Quintes, Susanne, Wicher, GK, Chabrol, Elodie, Latouche, Morwena, Chabrol, E, Behrens, A, Mirsky, R, Woodhoo, Ashwin, Jenkins, B, Mitter, Richard, Quintes, S, Turmaine, M, Greensmith, L, Woodhoo, A, Mitter, R, Behrens, Axel, Raivich, Gennadij, Wicher, Grzegorz K.,, Latouche, M, Banerjee, Annbily, Arthur-Farraj, PJ, Wilton, DK, Banerjee, A, Rahman, Mary, Jessen, KR, Rahman, M, Greensmith, Linda, Raivich, G, Arthur-Farraj, Peter J., Wilton, Daniel K., Jessen, Kristjan R.   +33 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Astrocyte-specific deletion of ceruloplasmin exacerbates oxidative stress and demyelination in the spinal cord in a murine model of multiple sclerosis

Neurobiology of Disease
Astrocytic iron metabolism is essential for maintaining central nervous system (CNS) homeostasis, particularly in the context of neurodegenerative and demyelinating disorders such as multiple sclerosis (MS).
Karishma G. Kedari, Zachary Smith, Veronica T. Cheli, Jazmin G. Corral, Congying Wang, Pablo M. Paez   +5 more
doaj   +1 more source

Oligodendrocyte Development and Implication in Perinatal White Matter Injury

Frontiers in Cellular Neuroscience, 2021
Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events.
Mahsa Motavaf, Xianhua Piao, Xianhua Piao, Xianhua Piao, Xianhua Piao   +4 more
doaj   +1 more source

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis [PDF]

, 2013
PMCID: PMC3856490This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Amor, Sandra, Victor, M. (Marion), Gerritsen, Wouter, Kimberley Ummenthum, Reijerkerk, Arie, Puentes, F. (Fabiola), Amor, S, Fabiola Puentes, Ruth Huizinga, van der Star, BJ, Sandra Amor, van der Valk, P, Gerritsen, W. (Wouter), David Baker, Regina Peferoen-Baert, Baker, David, Markus Kipp, Marion Victor, Star, B.J. (Baukje) van der, Arie Reijerkerk, Pryce, Gareth, Baker, D, Victor, Marion, Pryce, K. (Karena), Victor, M, Peferoen-Baert, R, Paul van der Valk, Ummenthum, K, Victor, Marion Barbara, Beyer, C. (Cordian), Baker, D.A. (David), van der Star, Baukje J., Peferoen-Baert, Regina, Ummenthum, K. (Kimberley), Puentes, F, Amor, S. (Sandra), Ummenthum, Kimberley, Cordian Beyer, Baukje J van der Star, Reijerkerk, A, Huizinga, Ruth, Gareth Pryce, Peferoen-Baert, R.M.B. (Regina), Valk, P. (Paul) van der, Wouter Gerritsen, Huizinga, R, Puentes, Fabiola, Huizinga, R. (Ruth), Kipp, M, Gerritsen, W, Kipp, Markus, Beyer, C, Beyer, Cordian, Reijerkerk, A. (Arie), Kipp, M. (Markus), Pryce, G, van der Valk, Paul   +56 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

Journal of Neuroinflammation, 2011
Background Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops.
Reichert Fanny, Oldenborg Per-Arne, Liraz-Zaltsman Sigal, Gitik Miri, Rotshenker Shlomo   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

eLife, 2019
Myelin serves as an axonal insulator that facilitates rapid nerve conduction along axons. By transmission electron microscopy, a healthy myelin sheath comprises compacted membrane layers spiraling around the cross-sectioned axon. Previously we identified
Michelle S Erwig, Julia Patzig, Anna M Steyer, Payam Dibaj, Mareike Heilmann, Ingo Heilmann, Ramona B Jung, Kathrin Kusch, Wiebke Möbius, Olaf Jahn, Klaus-Armin Nave, Hauke B Werner   +11 more
doaj   +1 more source